丹栀逍遥散化裁方治疗慢性紧张型头痛（肝郁化火证）的临床疗效研究

发布时间：2018-06-19 06:39

本文选题：慢性紧张型头痛 + 肝郁化火　；参考：《广西中医药大学》2016年硕士论文

【摘要】：目的:通过观察丹栀逍遥散化裁方对慢性紧张型头痛(肝郁化火证)的临床症状及中医症候积分等的影响,评价其疗效及安全性,为其临床运用提供依据。方法:研究从广西玉林市中医院门诊选取64例符合西医诊断为慢性紧张型头痛,中医诊断为头痛病(肝郁化火证)的患者,采用完全随机数字表法,将患者平均分为对照组32例,使用单纯西药治疗(盐酸阿米替林片);治疗组32例,在对照组药物的基础上联合使用丹栀逍遥散化裁方治疗。两组患者均连续服药8周,计为一个疗程。分别观察两组患者慢性紧张型头痛积分、中医症候积分及安全性指标的变化情况,并对所得数据运用SPSS统计软件进行统计分析比较。结果:(1)慢性紧张型头痛疗效:治疗组总有效率为93.33%;对照组总有效率为80.00%。两组疗效相比有显著性差异(P0.05);(2)中医症候疗效:治疗组总有效率为90%;对照组总有效率为53.34%。两组疗效相比有显著性差异(P0.01);(3)慢性紧张型头痛积分:治疗组经治疗后慢性紧张型头痛总积分及总积分差值与对照组相比,具有非常显著性差异(P0.01)。治疗组治疗前后各项指标积分差异均具有显著性(P0.01),且治疗后头痛强度、时间、次数积分与对照组相比差异有统计学意义(P0.05),而伴随症状无明显差异(P0.05);(4)中医症候积分:治疗组经治疗后中医症候积分及总积分差值与对照组相比,差异具有显著性(P0.05);(5)安全性分析:治疗前后,所有患者血常规、肝肾功能、心电图检查均无明显异常变化,并未出现明显不良反应。结论:(1)丹栀逍遥散化裁方对慢性紧张型头痛(肝郁化火证)的各项中西医临床症状的改善明显优于对照组,具有良好的临床治疗效果。(2)丹栀逍遥散化裁方治疗慢性紧张型头痛(肝郁化火证)未出现明显的不良反应与毒副作用,安全性较好。
[Abstract]:Objective: to observe the effect of Danzhi Xiaoyao Sanhua recipe on the clinical symptoms and TCM syndromes of chronic tension headache (liver depression and fire syndrome), to evaluate its efficacy and safety, and to provide the basis for its clinical application. Methods: a total of 64 patients with chronic tension headache diagnosed by western medicine and headache by TCM (liver depression and fire syndrome) were selected from the outpatient department of Yulin traditional Chinese Medicine Hospital of Guangxi Province. The patients were divided into control group (n = 32) and control group (n = 32), which were treated with simple western medicine (amitriptyline hydrochloride tablets) and treatment group (n = 32) with Danzhi Xiaoyao Sanhua prescription on the basis of control group. The patients in both groups were treated continuously for 8 weeks as a course of treatment. The changes of chronic tension-type headache score, TCM symptom score and safety index were observed, and the data were analyzed and compared with SPSS software. Results: the total effective rate of chronic tension headache was 93.33 in the treatment group and 80.00in the control group. There was significant difference between the two groups in the curative effect of TCM symptom: the total effective rate of the treatment group was 90; the total effective rate of the control group was 53.34. There was significant difference in the curative effect between the two groups (P 0.01) the score of chronic tension headache: after treatment, the total score and the difference of total score of chronic tension headache in the treatment group were significantly different from those in the control group (P 0.01). In the treatment group, there were significant differences in the scores of each index before and after treatment, and the intensity and time of headache after treatment. Compared with the control group, the scores of times were significantly different from those of the control group (P 0.05), but there was no significant difference in the syndromes associated with the symptoms. (2) the TCM symptom score and the total integral difference between the treatment group and the control group were compared with those in the control group, and there was no significant difference between the treatment group and the control group. Before and after treatment, there were no obvious abnormal changes in blood routine, liver and kidney function, electrocardiogram, and no obvious adverse reactions. Conclusion the effect of Danzhi Xiaoyao Sanhua recipe on the clinical symptoms of chronic tension headache (liver depression and fire syndrome) is obviously better than that of the control group. It has good clinical effect. 2) Danzhi Xiaoyao Sanhua prescription has no obvious adverse reactions and side effects in the treatment of chronic tension headache (liver depression and fire syndrome), and the safety is good.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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