抗结核胶囊治疗脊柱结核的疗效观察

发布时间：2018-06-19 11:47

本文选题：脊柱结核 + 抗结核胶囊　；参考：《广西中医药大学》2016年硕士论文

【摘要】：目的:观察抗结核胶囊配合一线抗结核西药治疗寒凝血瘀型脊柱结核的临床疗效,评价中药抗结核胶囊的有效性,为在临床中推广应用提供依据。方法:研究方法采用随机对照的方法,选择2014年10月—2015年6月广西中医药大学附属瑞康医院和广西中医药大学第一附属医院脊柱科收治的门诊及住院确诊患者60例,采用简单随机分组方法,病例随机分为治疗组和对照组,两组各30例,治疗组选择口服本院制剂“抗结核胶囊”,并配合当前一线抗结核西药治疗,对照组仅选择当前一线抗结核西药治疗,西药抗结核均按照标准疗法。分别在治疗足疗程后进行疗效评定,观察记录两组实验室检查、视觉疼痛模拟评分(VAS)、平均疼痛时间等结果,并进行统计学分析。结果:入选60例确诊患者均完成了整个治疗过程,无一例脱落。经统计学分析,治疗组和对照组入选病例中,患者年龄、性别、病情等方面无明显统计学差异(P0.05),无统计学意义;治疗足疗程后,治疗组在降低红细胞血沉率(ESR)、缓解疼痛、缩短疼痛时间方面,与对照组相比有明显差异(P0.05),有统计学意义;在药物对肝肾功能损伤方面,两组对比统计无明显差异(P0.05),无统计学意义。治疗组在治疗过程中未出现严重药物毒副作用。结论:中药抗结核胶囊配合一线抗结核西药治疗寒凝血瘀型脊柱结核较单纯一线抗结核西药治疗,在降低血沉、缓解疼痛、减少疼痛时间方面有更明显优势,并且追加中医药抗结核胶囊后,没有加重对肝肾功能的损伤,在治疗中患者的依从性比较高,中药抗结核胶囊配合一线抗结核西药治疗是一种在临床上有效、方便、安全的中西医结合治疗方案,值得广泛推广和应用。
[Abstract]:Objective: to observe the clinical effect of anti-tuberculosis capsule combined with first-line anti-tuberculosis western medicine in treating spinal tuberculosis with cold coagulation and blood stasis, and to evaluate the effectiveness of anti-tuberculosis capsule in order to provide the basis for clinical application. Methods: 60 outpatients and inpatients were selected from Ruikang Hospital affiliated to Guangxi University of traditional Chinese Medicine and Department of Spine of the first affiliated Hospital of Guangxi University of traditional Chinese Medicine from October 2014 to June 2015. The patients were randomly divided into treatment group (n = 30) and control group (n = 30). The control group only selected the current first-line anti-tuberculosis medicine treatment, western medicine anti-tuberculosis treatment according to the standard. The results of laboratory examination visual pain analogue score and average pain time were recorded and statistically analyzed. Results: all the 60 patients completed the whole treatment process, none of them dropped off. After statistical analysis, there was no significant difference in age, sex, condition of the patients between the treatment group and the control group (P 0.05), there was no statistical significance; after treatment, the erythrocyte sedimentation rate (ESR) was reduced and the pain was alleviated in the treatment group. Compared with the control group, there was a significant difference in pain time between the two groups (P 0.05), but there was no significant difference between the two groups in terms of liver and kidney function injury, there was no significant difference between the two groups. No serious side effects were observed in the treatment group. Conclusion: the combination of anti-tuberculosis capsule and first-line antituberculous medicine in the treatment of spinal tuberculosis with cold coagulation and blood stasis has more obvious advantages in reducing erythrocyte sedimentation rate, relieving pain and reducing pain time than that of single first-line anti-tuberculosis western medicine. After adding anti-tuberculosis capsule of traditional Chinese medicine, the injury to liver and kidney function was not aggravated, the compliance of patients was high in treatment. The combination of anti-tuberculosis capsule and first-line anti-tuberculosis medicine was effective and convenient in clinic. Safe treatment of integrated Chinese and western medicine, worthy of extensive promotion and application.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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