金匮泽泻汤颗粒治疗心下支饮型良性阵发性位置性眩晕的临床研究

发布时间：2018-06-20 20:12

本文选题：良性阵发性位置性眩晕 + 泽泻汤　；参考：《中国中医基础医学杂志》2017年08期

【摘要】：目的:观察《金匮要略》经方泽泻汤颗粒(以下简称"金匮泽泻汤颗粒")治疗良性阵发性位置性眩晕(BPPV)的临床疗效和安全性。方法:选择中国中医科学院广安门医院、河南省中医院、北京博爱医院门诊就诊的BPPV患者212例,按随机数字表法分为治疗组(92例)和对照组(120例)。对照组给予改良Epley复位法,治疗组在对照组基础上给予金匮泽泻汤颗粒辨证加减,在治疗后第2天、2周、3个月进行眩晕残障程度、临床疗效、不良事件的评定。结果:治疗组在治疗后2 d、2周、3个月的DHI评分较同期对照组评分改善明显,治疗组在治疗后2 d、2周、3个月总有效率(76.09%、88.04%、95.65%)均优于对照组(61.67%、73.33%、83.33%)。治疗组病例变位试验、单侧水平半规管功能参数治疗后2 d、2周、3个月的阳性率低于对照组,随访3个月与治疗后2 d比较差异有统计学意义,组间不良反应发生情况差异无统计学意义。结论:金匮泽泻汤颗粒能改善心下支饮型良性阵发性位置性眩晕耳石复位后的临床疗效,减轻眩晕的残障程度及前庭功能,具有一定的远期疗效,临床安全性较好。
[Abstract]:Objective: to observe the clinical efficacy and safety of Jingzexie decoction (JKZD) in the treatment of benign paroxysmal positional vertigo (BPPVV). Methods: 212 BPPV patients were selected from Guanganmen Hospital of Chinese Academy of traditional Chinese Medicine, Henan traditional Chinese Medicine Hospital and Beijing Boai Hospital. According to the method of random digital table, 212 BPPV patients were divided into treatment group (n = 92) and control group (n = 120). The control group was treated with modified Epley reduction method, the treatment group was treated with Jinkui Zexie decoction on the basis of syndrome differentiation and subtraction, and the degree of vertigo and disability, clinical effect and adverse events were evaluated at 2 weeks and 3 months after treatment. Results: the DHI scores of the treatment group at 2 days and 3 months after treatment were significantly improved than those of the control group. The total effective rate of the treatment group was 76.09 at 2 weeks and 3 months after the treatment. The total effective rate of the treatment group was higher than that of the control group (61.6773.33 and 83.33). The positive rate of unilateral horizontal semicircular canal function parameters in the treatment group was significantly lower than that in the control group at 2 weeks and 3 months after treatment. There was a significant difference between the follow-up of 3 months and 2 days after treatment. There was no significant difference in the incidence of adverse reactions between groups. Conclusion: Jinguizexie decoction can improve the clinical effect after the reduction of the benign paroxysmal positional vertigo otolith, alleviate the degree of disability and vestibular function of vertigo, have some long-term curative effect, and the clinical safety is better.
【作者单位】：河南省中医院;首都医科大学附属北京潞河医院;北京中医药大学第三附属医院;青海红十字医院;中国康复研究中心北京博爱医院;中国中医科学院;
【基金】：国家自然科学基金资助项目(81473514)-中药注射剂不良反应随机森林信号模型建立及免疫毒理学评价方法研究
【分类号】：R255.3

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