藏药翼首草抗类风湿性关节炎活性成分靶点的网络药理学研究

发布时间：2018-06-21 00:33

本文选题：藏药翼首草 + 网络药理学　；参考：《中国药房》2017年19期

【摘要】：目的:探索藏药翼首草治疗类风湿性关节炎(RA)的多成分、多靶点、多途径作用机制。方法:将选取的目标化合物(即翼首草10个化学成分结构)采用相关软件进行数据的导入和存储,使用Pharm Mapper和Drug Bank数据库进行靶点预测和筛选,通过MAS 3.0数据库对靶点进行通路获取并分析,最后使用Cytoscape 3.4.0软件构建翼首草"活性成分-靶点-通路"网络。结果:将Pharm Mapper数据库中获得的靶点信息与Drug Bank数据库中与炎症相关药物的靶点进行比对,得到26个可能与翼首草治疗RA相关的潜在作用靶点,其中MAPK14、RXRA、ALB、PDE4D、VDR等靶点可能是翼首草活性成分治疗RA的主要潜在靶点基因群;26个作用靶点通过通路注释后得到57条作用通路,除27条与RA相关外,还涉及与内分泌调节、免疫相关的其他30条作用通路。结论:根据网络药理学研究结果认为,翼首草可通过作用于炎症、免疫、内分泌等相关的靶点及通路,发挥治疗RA的作用。
[Abstract]:Objective: to explore the multi-component, multi-target and multi-pathway action mechanism of Rhizoma Astragalus in the treatment of rheumatoid arthritis (RA). Methods: the selected target compounds (i.e., 10 chemical composition structures of Pharm Mapper and Drug Bank) were used to import and store the data, and the target sites were predicted and screened using Pharm Mapper and Drug Bank databases. The target was acquired and analyzed by MAS 3.0 database. Finally, the "active Component-Target Pathway" network was constructed by using the software of Cytoscape 3.4.0. Results: the target information obtained from the Pharm Mapper database was compared with the targets of anti-inflammatory drugs in the Drug Bank database, and 26 potential targets related to the treatment of RA by Pharm Mapper were obtained. The target sites such as MAPK14, RXRAB, PDE4D, VDR and so on may be the main potential target gene groups for the treatment of RA by active components of Acanthopsis pterygii, and 57 action pathways are obtained by means of pathway annotation of 26 targets, including 27 related to RA, and also related to endocrine regulation. Other 30 other immune-related pathways. Conclusion: according to the results of the network pharmacological studies, it is concluded that Acanthopsis pterygii can play a role in the treatment of RA by acting on inflammatory, immunological, endocrine and other related targets and pathways.
【作者单位】：成都中医药大学民族医药学院;
【基金】：国家自然科学基金面上项目(No.81274193) 四川省教育厅省属高校科研创新团队建设计划项目(No.11TD004)
【分类号】：R29

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