醒脑静注射液治疗登革热的临床观察

发布时间：2018-06-21 08:33

本文选题：登革热 + 中医疗法　；参考：《广州中医药大学》2016年硕士论文

【摘要】：目的：本研究观察醒脑静注射液对登革热(卫气同病证)患者的作用,通过其对中医症候积分、退热天数、白细胞计数及血小板计数的影响,评价醒脑静注射的疗效及安全性,旨在为中医药治疗登革热提供一种临床参考。方法：选取符合纳入标准的54例登革热(卫气同病证)为研究对象,随机分为治疗组和对照组,每组27例。对照组给予一般对症支持治疗：降温、静脉及口服补液、止血护胃等；治疗组加用醒脑静注射液20m静脉滴注,一天一次,疗程均为5天,使用时予0.9%氯化钠250m1或5%葡萄糖250m1稀释。观察指标：中医症候积分、退热天数、白细胞计数、血小板计数等。对比治疗组与对照组治疗前后及对照组与治疗组组间的差异。结果：1.两组患者在年龄、性别、皮疹发生情况、治疗前肝肾功能两两比较,差异无统计学意义(P0.05),具有可比性。2.两组治疗前中医症候积分组间比较,差异无统计学意义(P0.05)；两组治疗后与治疗前比较,症状改善明显,差异有统计学意义(P0.05)；治疗组与对照组治疗后比较,差异有统计学意义(P0.05)。3.治疗组退热天数短于对照组,两组比较,差异有统计学意义(P0.05)。4.两组治疗前白细胞计数组间比较,差异无统计学意义(P0.05)；两组治疗后与治疗前比较,白细胞计数提升明显,差异有统计学意义(P0.05)；治疗组与对照组治疗后比较,差异有统计学意义(P0.05)。5.两组治疗前血小板计数组间比较,差异无统计学意义(P0.05)；治疗组治疗后与治疗前比较,血小板计数提升明显,差异有统计学意义(P0.05)；对照组治疗后与治疗前比较,血小板计数提升不明显,差异无统计学意义(P0.05)；治疗组与对照组治疗后比较,差异无统计学意义(P0.05)。结论：1.两组均可改善患者临床症状,但治疗组症状改善更明显。2.醒脑静注射液能更快使登革热(卫气同病证)患者降温,在缩短退热天数方面优于对照组。3.治疗组白细胞计数、血小板计数提升更高,治疗后白细胞计数、血小板计数平均值均高于对照组,两组治疗后两项指标数据均未超过参考值范围。4.醒脑静注射液治疗登革热具有较好的安全性。
[Abstract]:Objective: to observe the effect of Xingnaojing injection (Xingnaojing injection) on patients with dengue fever (Wei Qi syndromes syndrome), and to evaluate the efficacy and safety of Xingnaojing injection through its effect on TCM symptom score, antipyretic days, white blood cell count and platelet count. To provide a clinical reference for the treatment of dengue fever with traditional Chinese medicine. Methods: 54 cases of dengue fever were randomly divided into treatment group and control group with 27 cases in each group. The control group was given general symptomatic support therapy: cooling, intravenous and oral rehydration, hemostasis and stomach protection, and the treatment group were treated with Xingnaojing injection 20m intravenous drip once a day for 5 days. When used, 0.9% sodium chloride 250m1 or 5% glucose 250m1 were diluted. Indicators: TCM symptom score, antipyretic days, white blood cell count, platelet count, etc. The difference between the treatment group and the control group before and after treatment and between the control group and the treatment group was compared. The result is 1: 1. There was no significant difference between the two groups in age, sex, rashes, liver and kidney function before treatment, there was no significant difference between the two groups (P 0.05). There was no significant difference in the scores of TCM symptoms between the two groups before treatment, there was no significant difference between the two groups before and after treatment, the symptoms of the two groups were obviously improved after treatment and the difference was statistically significant (P 0.05), and the difference between the treatment group and the control group was statistically significant after treatment. The days of antipyretic in the treatment group was shorter than that in the control group, and the difference between the two groups was statistically significant. There was no significant difference in white blood cell count between the two groups before treatment (P 0.05); after treatment and before treatment, the white blood cell count increased significantly in the two groups, and the difference was statistically significant (P 0.05), while that in the treatment group was higher than that in the control group (P 0.05). The difference was statistically significant (P 0.05). There was no significant difference in platelet count between the two groups before treatment (P 0.05); in the treatment group, the platelet count increased significantly after treatment and before treatment, and the difference was statistically significant (P 0.05); in the control group, it was compared with that before treatment. There was no significant difference in platelet count between the treatment group and the control group (P 0.05). Conclusion 1. Both groups were able to improve the clinical symptoms, but the treatment group was more obvious. 2. 2. Xingnaojing injection can lower the temperature of patients with dengue fever faster than the control group in reducing the days of fever. The leukocyte count and platelet count in the treatment group were higher than those in the control group. After treatment, the mean white blood cell count and platelet count were higher than those in the control group, and the two indexes in both groups did not exceed the reference value range. 4. Xingnaojing injection has good safety in treating dengue fever.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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