基于恐惧记忆的形成和消退论肾精的安神定志效应

发布时间：2018-06-21 14:56

  本文选题：肾精 + 安神定志　； 参考：《中医杂志》2017年13期

【摘要】：中医学认为肾藏精,在志为恐,肾精是肾发挥调节情志功能的物质基础和根本保证。当机体处于惊恐应激时,肾精不足既能易化恐惧记忆的形成,又能巩固恐惧记忆使之难以消退;而恐惧记忆的固化又使患者长期处于高度恐惧或极易恐惧的状态,进一步耗损肾精。前额叶皮质-杏仁核-海马是与恐惧记忆形成和消退密切相关的神经回路,补肾方药对恐惧记忆形成和消退具有重要的调节作用。基于此提出"以前额叶皮质-杏仁核-海马为作用通路,肾精可通过影响与恐惧记忆密切相关的应激激素(神经肽)和神经递质及其受体的合成释放与表达,进而整体性地调控激素与递质系统间的相互作用,发挥其安神定志促进恐惧消退的效应"的科学假说,并从动物模型、激素与神经递质以及表观遗传学机制等方面对今后的研究思路进行初步探讨。
[Abstract]:Traditional Chinese medicine holds that the kidney contains essence and the kidney essence is the material basis and fundamental guarantee of regulating the function of emotion. When the body is in panic stress, deficiency of kidney essence can not only facilitate the formation of fear memory, but also consolidate fear memory and make it difficult to fade away; and the solidification of fear memory makes patients in a state of high fear or high risk of fear for a long time. Further depletion of kidney essence. Prefrontal cortex amygdala and hippocampus are the neural circuits closely related to the formation and regression of fear memory. The prescription of tonifying kidney plays an important role in regulating the formation and regression of fear memory. Based on this, it is suggested that "prefrontal cortex, amygdala and hippocampus play an important role in the release and expression of stress hormones (neuropeptides), neurotransmitters and their receptors, which are closely related to fear memory." In turn, the scientific hypothesis of regulating the interaction between hormones and transmitters, and exerting its calming effect on fear regression, "and from animal models, Hormone, neurotransmitter and epigenetic mechanism were discussed in the future.
【作者单位】： 广州中医药大学基础医学院;
【基金】：国家自然科学基金(30873207) 广东省自然科学基金(2016A030313648)
【分类号】：R277.7
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本文编号：2049136