三参四黄降糖胶囊治疗气阴两虚夹瘀型2型糖尿病的临床观察

发布时间：2018-06-22 06:24

本文选题：三参四黄降糖胶囊 + 气阴两虚夹瘀型　；参考：《湖北民族学院》2016年硕士论文

【摘要】：目的:客观评价中药复方制剂三参四黄降糖胶囊对气阴两虚夹瘀型2型糖尿病的临床疗效。方法:本课题选取80例符合纳入标准的建始县中医院门诊及住院2型糖尿病患者,并随机分为观察组和对照组,每组各40例。所选患者治疗疗程中均进行糖尿病宣教,并配合饮食、运动疗法。对照组给予人胰岛素注射,初始剂量0.44U/(kg d),餐前30min皮下注射,每日2次,早晚餐前按1:1比例分配,并根据空腹血糖和餐后2h血糖水平调整胰岛素剂量,1个月为1个疗程,连续治疗3个疗程评定疗效。观察组在对照组的基础上加用三参四黄降糖胶囊(由建始县中医院生产并经恩施州药监局批准,批准文号ZC2004003),每次4粒,每日3次口服。观察两组患者治疗前后中医临床症状、空腹血糖(FPG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbAlc)及安全性指标方面的情况。两组患者在性别、年龄、病程、治疗前各观察指标方面无显著性差异,具有可比性。结果:两组患者总疗效比较,观察组总有效率为90.32%,对照组总有效率为78.79%,经统计学分析得出,P0.05,差异具有显著性,说明观察组总疗效优于对照组。在中医证候方面,观察组与对照组治疗后组间比较,P0.05,差异具有显著性,观察组优于对照组。在空腹血糖、餐后2小时血糖、糖化血红蛋白方面,观察组与对照组治疗后组间比较,P0.05,差异具有显著性,观察组优于对照组。两组疗程期间未发生明显的药物不良反应。结论:两组方法对2型糖尿病(气阴两虚夹瘀型)均有较好的疗效。但三参四黄降糖胶囊联合人胰岛素治疗气阴两虚夹瘀型2型糖尿病的疗效明显优于单纯西药组,且具有良好的安全性,值得进一步推广应用。
[Abstract]:Objective: to evaluate the clinical effect of Sanshen Sihuang Jiangtang capsule, a compound preparation of traditional Chinese medicine, on type 2 diabetes mellitus with deficiency of qi and yin. Methods: 80 patients with type 2 diabetes mellitus were randomly divided into observation group and control group with 40 cases in each group. The selected patients were treated with diabetes education, diet and exercise therapy. The control group was injected with human insulin. The initial dose of 0.44 U / (kg d), 30min was injected subcutaneously twice a day. The morning and evening preprandial 30min was distributed according to 1:1 ratio. The insulin dosage was adjusted according to fasting blood glucose and 2 h postprandial blood glucose level. One month was a course of treatment. Three consecutive courses of treatment were used to evaluate the efficacy. The observation group was treated with Sanshen Sihuang Jiangtang capsule on the basis of the control group (produced by Jianshixian traditional Chinese Medicine Hospital and approved by the Bureau of Drug Supervision of Enshi Prefecture, approved ZC2004003), 4 capsules each time, three times a day. The clinical symptoms, fasting blood glucose (FPG), postprandial blood glucose (2 h PBG), glycosylated hemoglobin (HbAlc) and safety indexes were observed before and after treatment. There were no significant differences in sex, age, course of disease and observed indexes before treatment between the two groups. Results: the total effective rate was 90.32 in the observation group and 78.79 in the control group. The statistical analysis showed that the total effective rate of the observation group was better than that of the control group. In TCM syndromes, the observation group was better than the control group in comparison with the control group after treatment (P 0.05), there was a significant difference between the observation group and the control group. There were significant differences in fasting blood glucose, 2 hours postprandial blood glucose and glycosylated hemoglobin between the observation group and the control group after treatment (P 0.05), and the observation group was superior to the control group. No significant adverse drug reactions occurred during the course of treatment in the two groups. Conclusion: the two methods have better curative effect on type 2 diabetes mellitus. But Sanshen Sihuang Jiangtang capsule combined with human insulin in the treatment of type 2 diabetes mellitus with deficiency of qi and yin and deficiency of blood stasis was better than that of western medicine group, and had good safety, which was worthy of further popularization and application.
【学位授予单位】：湖北民族学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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