益气养阴化瘀颗粒治疗阴虚血瘀型慢性萎缩性胃炎的临床研究

发布时间：2018-06-24 00:01

本文选题：萎缩性胃炎 + 益气养阴化瘀　；参考：《安徽中医药大学》2016年硕士论文

【摘要】：1目的观察益气养阴化瘀颗粒对慢性萎缩性胃炎患者临床疗效及胃蛋白酶原及胃泌素的影响。2方法选择符合标准的CAG患者64例,随机分成二组:治疗组32例与对照组32例,治疗组给予益气养阴化瘀颗粒口服,对照组予以胃复春口服。疗程12周,随访12周,观察两组患者治疗前后对临床症状、胃镜下表现、病理、胃蛋白酶原及胃泌素的变化。3结果3.1临床疗效:治疗后,两组患者胃脘痛、痞满、嘈杂、纳差症状均有改善;治疗组痞满、嘈杂症状的改善起效较对照组快;痞满、嘈杂、纳差症状的改善,治疗组疗效优于对照组,差异有统计学意义(P0.01或P0.05);治疗组证候总有效率高于对照组(P0.05)。3.2胃镜下表现:两组治疗后胃黏膜情况均有改善,治疗组有效率高于对照组,差异有统计学意义(P0.05)。3.3组织病理:两组治疗后胃黏膜萎缩、肠化均有改善。对胃黏膜萎缩的改善,治疗组有效率为87.5%,对照组为62.5%;对肠化的改善,治疗组有效率为91.7%,对照组为60.9%,治疗组胃黏膜萎缩及肠化的改善均优于对照组(P0.05)。3.4胃蛋白酶原水平:治疗后两组PGⅠ的水平均有提高,且治疗组疗效优于对照组(P0.05);两组PGII水平治疗前后比较,差异无统计学意义(P0.05)。3.5胃泌素水平:治疗后两组G17的水平均有提高,治疗组疗效优于对照组,差异有统计学意义(P0.05)。3.6远期疗效观察:随访12周,治疗组症候疗效总有效率为62.5%,对照组为50.0%,差异无统计学意义。(P0.05)4结论4.1益气养阴化瘀颗粒能较好的改善阴虚血瘀型患者的临床症状。4.2益气养阴化瘀颗粒能很好的改善阴虚血瘀型患者的病理组织,在胃黏膜萎缩及胃黏膜肠化的治疗上明显优于为胃复春组。4.3益气养阴化瘀颗粒能很好的改善阴虚血瘀型患者的胃镜下胃黏膜情况,且优于胃复春组。4.4益气养阴化瘀颗粒能促进胃蛋白酶原Ⅰ及胃泌素的分泌。4.5益气养阴化瘀颗粒与胃复春远期疗效相当。
[Abstract]:1 Objective To observe the effect of Yiqi Yangyin Huayu Granule on the clinical efficacy of chronic atrophic gastritis and the effect of pepsinogen and gastrin in the.2 method, 64 patients with standard CAG were selected and divided into two groups randomly: 32 cases in the treatment group and 32 cases in the control group. The treatment group was given Yiqi Yangyin Huayu granule orally, and the control group was given Wei Fuchun oral administration. The course of treatment was 12. Week, follow up 12 weeks, observe the clinical symptoms, gastroscope, pepsinogen and gastrin changes.3 results in two groups of patients before and after treatment 3.1 clinical results: after treatment, the two groups of patients with epigastric pain, fullness, noise, and dysphasia were improved; the treatment group was full, noisy symptoms improved faster than the control group; ruffian, noisy, Na differential disease. The curative effect of the treatment group was better than the control group (P0.01 or P0.05); the total effective rate of the syndrome in the treatment group was higher than that of the control group (P0.05).3.2 Gastroscope: the two groups were improved after the treatment. The effective rate of the treatment group was higher than that of the control group. The difference was statistically significant (P0.05).3.3 histopathology: the gastric mucus after treatment. The efficiency of the treatment group was 87.5%, the control group was 62.5%, the efficiency of the treatment group was 91.7% and the control group was 60.9%. The improvement of gastric mucosa atrophy and intestinal metaplasia in the treatment group was better than that of the control group (P0.05).3.4 pepsinogen level: the level of the two groups of PG I after treatment were raised. The curative effect of the treatment group was better than the control group (P0.05), and the difference between the two groups before and after the treatment of PGII was not statistically significant (P0.05).3.5 gastrin level: after the treatment, the level of G17 in the two groups was improved, the curative effect of the treatment group was better than the control group, the difference was statistically significant (P0.05).3.6 long-term effect observation: the follow-up was 12 weeks, the treatment group's symptoms were effective and effective. The rate was 62.5% and the control group was 50%. (P0.05) 4 Conclusion 4.1 Yiqi Yangyin Huayu granule could better improve the clinical symptoms of yin deficiency and blood stasis syndrome,.4.2 Yiqi Yangyin Huayu granule could improve the pathological tissue of the patients with Yin deficiency and blood stasis, and it was obviously better than the stomach in the treatment of gastric mucosa atrophy and gastric mucosa intestinal metaplasia. The.4.3 Yiqi nourishing yin and removing stasis granule can improve the gastric mucosal condition of the patients with Yin deficiency and blood stasis, and it is superior to the.4.4 Yiqi Yangyin Huayu granule in the Wei Fuchun group, which can promote the secretion of pepsinogen I and the secreting of gastrin,.4.5, Yiqi Yangyin Huayu granule and the long-term effect of Wei Fuchun.
【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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