温阳益气法治疗病态窦房结综合征的系统评价及其用药规律分析

发布时间：2018-06-28 10:27

本文选题：病态窦房结综合征 + 温阳益气　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:运用循证医学系统评价的方法对温阳益气法治疗病态窦房结综合征的临床研究文献进行分析。基于数据挖掘,探索病窦综合征的用药特点、配伍规律,为中药治疗病窦提供科学依据和新的思路。方法:1.通过电子检索和手工检索,检索温阳益气法治疗病态窦房结综合征的临床随机对照试验研究,采用Jadad评分标准评价纳入研究文献质量,利用RevMan5.2软件对多个研究结果的总体效应进行Meta-分析、倒漏斗图分析。2.基于数据挖据,运用SPSS 17.0软件进行数据的一般处理、频数分析等,选择PSS Clementine 12.0软件进行关联规则分析,探索用药规律。结果:1.系统评价共纳入16篇随机对照临床试验,共1181例患者,Jadad评分示文献质量普遍比较低。Meta-分析结果示:临床疗效比较的合并效应量RR(relative risk)及95%CI为:1.41[1.24,1.61];动态心电图比较的合并效应量RR(relative risk)及95%CI为:2.67[2.05,3.48];平均心率比较的合并效应量MD(mean difference)及95%CI为:5.52[2.85,8.19];24h总心率比较的合并效应量SMD(standardized mean difference)及95%CI为:0.87[0.50,1.24];最快心率比较的合并效应量MD(mean difference)及95%CI为:3.95[-2.53,10.43];最慢心率比较的合并效应量MD(mean difference)及95%CI为:2.53[0.07,5.00];窦房结恢复时间(SNRT)比较的合并效应量SMD(standardized mean difference)及95%CI为:-0.57[-0.86,-0.27];窦房结传导时间(SACT)比较的合并效应量SMD(standardized mean difference)及95%CI为:-1.41[-2.31,-0.51]。2.数据挖掘结果示:使用频次比较多的药物类别是补虚药、温里药、解表药、活血化瘀药;病态窦房结综合征用药的主要配伍如下:补气药与温里药的配伍,解表药与温里药的配伍,以及温里药、补虚药、解表药的联合应用。结论:温阳益气法治疗病态窦房结综合征疗效确切,安全性高。数据挖掘病态窦房结综合征的用药特点及配伍规律,为临床用药提供指导。
[Abstract]:Objective: to analyze the literature on the treatment of sick sinus syndrome (SSS) with the method of warming yang and nourishing qi by using the method of systematic evaluation of evidence-based medicine. Based on data mining, this paper explores the characteristics and compatibility of drugs used in the treatment of sick sinus syndrome, and provides a scientific basis and a new way of thinking for the treatment of sick sinus with traditional Chinese medicine. Method 1: 1. Through electronic search and manual retrieval, the clinical randomized controlled trial of warming yang and supplementing qi method for treating sick sinus syndrome was searched, and Jadad scoring standard was used to evaluate the quality of the research literature. Using Revman 5.2 software, the overall effect of multiple research results was analyzed by Meta- analysis and inverted funnel graph analysis. 2. 2. Based on data mining and SPSS 17.0 software for general data processing and frequency analysis, PSS Clementine 12.0 software was selected to analyze association rules and explore the rule of drug use. The result is 1: 1. A total of 16 randomized controlled clinical trials were reviewed. A total of 1181 patients' Jadad scores showed that the quality of literature was generally low. The results of Meta- analysis showed that the combined effects of clinical efficacy comparison were RR (relative risk) and 95 CI were: 1: 1 41 [1. 24 卤1. 61]; RR (relative risk) and 95 CI compared with dynamic electrocardiogram were 2. 67 [2. 0553. 48]; The combined effects of SMD (standardized mean difference) and 95 CI were 0.87 [0.500.24]; the combined effects of MD (mean difference) and 95CI were 3.95 [-2.5310.43]; the combined effects of the slowest heart rate were 2.53 [0.075.00]; The combined effects of SMD (standardized mean difference) and 95 CI were: -0.57 [-0.86U -0.27], and SMD (standardized mean difference) and 95 CI of sinus node conduction time were: -1.41 [-2.31 卤0.51] .2. The results of data mining show that the most frequently used drugs are tonifying drugs, warm medicine, antipods, promoting blood circulation and removing blood stasis; the main compatibility of the drugs used in sick sinus syndrome is as follows: the compatibility of tonifying qi medicine with warm medicine, The compatibility of antiepiderms with warm medicine, as well as the combined application of mild medicine, tonifying medicine and antitabular medicine. Conclusion: the therapy of warming yang and nourishing qi is effective and safe in the treatment of sick sinus syndrome. Data mining sick sinoatrial syndrome drug characteristics and compatibility, to provide guidance for clinical use.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【参考文献】