伴有颈动脉粥样硬化的脑卒中高危人群证候要素与同型半胱氨酸的相关性研究

发布时间：2018-06-28 19:49

本文选题：颈动脉粥样硬化 + 脑卒中高危人群　；参考：《中华中医药杂志》2017年02期

【摘要】：目的:研究伴有颈动脉粥样硬化(CAS)的脑卒中高危人群证候要素与同型半胱氨酸(Hcy)的相关性。方法:设计前瞻性观察方案,按统一诊断、纳入标准、排除标准,选取伴有CAS的脑卒中高危人群3 716例,观察中医四诊信息,通过频数分析、因子分析等统计方法,提取证候要素;同时测定血清中Hcy水平,运用Spearman相关系数分析伴有CAS的脑卒中高危人群颈动脉粥样硬化斑块数量与Hcy的相关性。结果:伴有CAS的脑卒中高危人群的主要证候要素是火、阴虚与气虚,次要证候要素是血瘀、阳虚、痰。伴有CAS的脑卒中高危人群颈动脉粥样硬化斑块数量与Hcy水平正相关,Spearman相关系数为0.140(P0.01);伴有CAS的脑卒中高危人群随着Hcy水平升高,气虚证比例显著降低(P0.01),血瘀证比例显著升高(P0.01);伴有CAS的脑卒中高危人群随着颈动脉粥样硬化斑块形成,阳虚证比例增高(P0.05)。结论:伴有CAS的脑卒中高危人群颈动脉粥样硬化斑块数量随Hcy升高而增多,阳虚寒凝可能是影响伴有CAS的脑卒中高危人群动脉粥样硬化斑块形成的关键因素。
[Abstract]:Aim: to study the correlation between syndromes and homocysteine (Hcy) in high risk stroke patients with carotid atherosclerosis (CAS). Methods: according to the unified diagnosis, inclusion criteria, exclusion criteria, 3 716 cases of high risk population of stroke with CAS were selected to observe the information of four diagnoses of TCM, and the statistical methods such as frequency analysis and factor analysis were used. At the same time, the serum Hcy level was measured, and the correlation between the number of carotid atherosclerotic plaques and Hcy was analyzed by Spearman correlation coefficient. Results: the main syndromes of high risk population with CAS were fire, yin deficiency and qi deficiency, and secondary syndromes were blood stasis, yang deficiency and phlegm. The correlation coefficient between the number of carotid atherosclerotic plaques and the level of Hcy was 0.140 (P0.01). The proportion of qi deficiency syndrome significantly decreased (P0.01), the proportion of blood stasis syndrome significantly increased (P0.01); with the formation of carotid atherosclerotic plaque, the proportion of Yang deficiency syndrome increased (P0.05). Conclusion: the number of carotid atherosclerotic plaque increases with the increase of Hcy in the high risk population of stroke with CAS. Yang deficiency and cold coagulation may be the key factors influencing the formation of atherosclerotic plaque in the high risk population of stroke with CAS.
【作者单位】：北京中医医院顺义医院;北京中医药大学东方医院;北京市丰台区蒲黄榆社区卫生服务中心;北京市丰台区王佐社区卫生服务中心;
【基金】：2011年国家医改重大专项“国家脑卒中高危人群筛查与防治工程” 北京中医药大学科研创新团队项目(No.2011-CXTD-23) 2013重点学科开放课题“中医脑病”(No.2013-ZDXKKFKT-38)~~
【分类号】：R277.7

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