真实世界清开灵注射液治疗炎症因子异常患者的联合用药特征分析

发布时间：2018-06-29 00:00

本文选题：清开灵注射液 + 联合用药　；参考：《中国中药杂志》2017年10期

【摘要】：分析真实世界清开灵注射液治疗白细胞、C反应蛋白升高等炎症因子异常患者的联合用药特征。基于中国中医科学院中医临床基础医学研究所构建的来自全国16家大型三级甲等医院医院信息系统(hospital information system,HIS)的医疗电子数据仓库,提取其中使用清开灵注射液的C反应蛋白异常患者、白细胞异常患者,进行基本信息、中西医诊断信息、医嘱信息、实验室检查信息的分析,采用Apriori算法建立模型,使用Clementine 12.0进行关联分析,分析真实世界中清开灵注射液治疗C反应蛋白、白细胞等指标升高患者临床用药规律及联合用药特征。研究结果表明使用清开灵注射液治疗C反应蛋白异常患者,联用1种西药、中药时,联合用药频率最高的分别是维生素C(159例,占74.30%)、痰热清注射液(71例,占33.18%),联合2种中药时频次最高的是血栓通注射液+痰热清注射液(支持度10.75%);治疗白细胞异常患者,联合1种西药、中药时联合用药频率最高的分别是维生素C(596例,占56.02%)、感冒清热颗粒(247例,占23.21%),联合2种中药时频次最高的是双黄连+感冒清热颗粒(支持度5.26%),C反应蛋白异常患者和白细胞异常患者中,从药理作用角度看,西药中,与抗生素类、营养支持剂联合用药最为多见。可见,清开灵注射液治疗C反应蛋白、白细胞等炎症指标升高的患者,多与抗生素类药物联合用药,达到药效协同的作用。
[Abstract]:To analyze the characteristics of combined use of Qingkailing injection in the treatment of patients with abnormal inflammatory factors such as elevated leukocyte C reactive protein (WCRP). Based on the medical electronic data warehouse built by the Institute of Clinical basic Medicine of the Chinese Academy of traditional Chinese Medicine (CAS) from 16 large Grade 3A hospitals in China (hospital information system his), Among them, the patients with abnormal C-reactive protein and abnormal leukocytes were extracted from Qingkailing injection. The basic information, diagnostic information of traditional Chinese and western medicine, information of doctor's order, information of laboratory examination were analyzed, and the model was established by Apriori algorithm. Clementine 12.0 was used to analyze the clinical characteristics of the patients with elevated C-reactive protein and leukocyte in real world treated with Qingkailing injection. The results showed that the combined use of Qingkailing injection to treat patients with abnormal C-reactive protein was the highest frequency of vitamin C (159 cases, 74.30%) and Tanreqing injection (71 cases). The highest frequency of combination of two kinds of traditional Chinese medicine was Xuetong injection, Tanreqing injection (support degree 10.75%), and the combination of one western medicine and one kind of western medicine for patients with abnormal leukocyte were 596 cases of vitamin C, respectively. Accounting for 56.02%, Ganmao Qingre granules (247 cases, 23.21%). The highest frequency of combining two kinds of traditional Chinese medicine is Shuanghuanglian Ganqingre granules (support degree 5.26%) patients with abnormal C-reactive protein and patients with abnormal white blood cell. From the point of view of pharmacological action, Western medicine, Combined use of nutrition support agents is most common with antibiotics. It can be seen that Qingkailing injection in the treatment of C reactive protein, white blood cell and other inflammatory indicators of patients, and antibiotics combined with drugs to achieve synergistic effect.
【作者单位】：中国中医科学院中医临床基础医学研究所;北京工业大学;中国人民大学统计学院;
【基金】：国家自然科学基金面上项目(81473798) 国家“重大新药创制”科技重大专项(2014ZX09201022-005) 国家中医药管理局中医药行业科研专项(201507003) 北京市中医药科技专项(JJ2014-53)
【分类号】：R259

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