酒精性肝硬化患者中医证型与客观指标之间的相关性研究

发布时间：2018-06-30 00:34

本文选题：酒精性肝硬化 + 中医证型　；参考：《辽宁中医药大学》2016年硕士论文

【摘要】：目的:通过对酒精性肝硬化患者客观指标的总结归纳,了解其证型分布规律,分析该病中医证型与相关指标的关系,为酒精性肝硬化的中医辩证提供客观依据。方法:查阅2005年10月-2015年9月期间辽宁中医药大学附属医院肝病门诊的病例,参照纳入及排除标准筛选病例,将符合标准的233例病例作为研究对象进行回顾性分析,记录入选患者的姓名、性别、年龄、文化程度、每日摄入乙醇量、饮酒年限、中医辨证分型、主要症状、阳性体征、并发症,以及肝功能、凝血功能等相关指标,应用SPSS19.0统计软件对数据进行统计分析,以探讨中医证型与客观指标之间的相关性。结果:1.中医证型分布:将233例酒精性肝硬化患者辨证分为6型,其中以湿热蕴结证及脾阳不运证所占比例较高,分别约占31.33%和23.18%,其他证型均占20%以下。2.中医证型与客观指标的相关性:中医证型与年龄、每日摄入乙醇量、饮酒年限、ALB、A/G、AST、AST/ALT、ALP、GGT、PT、APTT、FIB均有相关性,其中各证型间ALB、AST/ALT、ALP、GGT、PT比较有显著差异(P0.01)。肝郁脾虚证患者的年龄均值最小,饮酒年限最短,ALB、FIB均值最高,PT、APTT均值最低;湿热蕴结证患者每日摄入乙醇量最高,AST/ALT、ALP均值最高;肝肾阴虚证患者饮酒年限最长,ALB、A/G、AST均值最低;瘀血阻络证患者AST均值最高;脾阳不运证患者GGT均值最低。结论:1.酒精性肝硬化患者中医证型与每日摄入乙醇量及饮酒年限直接相关。2.酒精性肝硬化患者中医证型与ALB、AST/ALT、ALP、GGT、PT密切相关。3.酒精性肝硬化患者以湿热蕴结证最为常见。
[Abstract]:Objective: to summarize the objective indexes of alcoholic cirrhosis patients, understand the distribution of syndrome types, and analyze the relationship between TCM syndromes and related indexes of alcoholic cirrhosis, so as to provide objective basis for TCM dialectical of alcoholic cirrhosis. Methods: from October 2005 to September 2015, the cases of liver diseases in affiliated hospitals of Liaoning University of traditional Chinese Medicine were reviewed, and 233 cases that met the criteria were retrospectively analyzed according to the inclusion and exclusion criteria. The names, sex, age, education level, daily alcohol intake, drinking years, TCM syndrome differentiation, main symptoms, positive signs, complications, liver function and coagulation function were recorded. The statistical software SPSS 19.0 was used to analyze the data in order to explore the correlation between TCM syndromes and objective indexes. The result is 1: 1. The distribution of TCM syndromes: 233 cases of alcoholic liver cirrhosis were divided into 6 types, of which the proportion of damp-heat accumulation syndrome and spleen yang non-transport syndrome was higher, accounting for 31.33% and 23.18% respectively, and the other syndrome types were all less than 20% .2. Correlation between TCM syndromes and objective indexes: there was a significant correlation between TCM syndromes and age, daily alcohol intake, alcohol consumption, ALBAST / AST / alt / AGT / PTTTFIB, among which there was a significant difference in ALBAST / alt / ALPGGTPT among different syndromes (P0.01). The patients with liver stagnation and spleen deficiency syndrome had the lowest mean age, the shortest drinking years and the highest mean value of ALB FIB and the lowest mean of PTT APTT; the highest daily intake of ethanol in the patients with damp-heat accumulation syndrome and the highest mean value of AST / ALT ALP; the longest drinking years in the patients with liver and kidney yin deficiency syndrome; The mean value of AST was the highest in patients with stagnation of blood and obstruction of collaterals, and the lowest in patients with syndrome of spleen yang. Conclusion 1. The TCM syndromes of alcoholic cirrhosis patients were directly related to alcohol intake and drinking duration. 2. 2. The TCM syndromes of alcoholic cirrhosis patients were closely related with ALBAST / alt / ALP GGTT PT. 3. The syndrome of dampness and heat accumulation is the most common in alcoholic cirrhosis.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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