基于关联规则挖掘分析中医内外合治对湿热痹阻型类风湿性关节炎患者免疫炎症氧化应激的影响

发布时间：2018-07-01 19:00

本文选题：类风湿性关节炎 + 中医药　；参考：《辽宁中医杂志》2017年07期

【摘要】：目的:应用关联规则和统计学方法分析本院风湿病科治疗湿热痹阻型类风湿性关节炎内服中药和外用药对患者免疫炎症、氧化应激的影响,探讨中医内外合治科学性,为优化治疗方案提供依据。方法:整理安徽中医药大学第一附属医院风湿病科2012年6月—2015年10月湿热痹阻型类风湿性关节炎住院患者的病历资料。采用SPSS 17.0和SPSS Clementine 12.0软件Aprior模块分析内服中药和外用药与免疫炎症及氧化应激变化的关系。结果:湿热痹阻型RA患者临床辨证用药可以分为四类,用药总频次以健脾化湿药最高。内服中药威灵仙、陈皮,黄芩、白花蛇舌草,山药、车前草,车前草、白花蛇舌草,红花、车前草,茯苓、蒲公英,茯苓,薏苡仁等和外用药芙蓉膏、消瘀接骨散均与RF、Hs-CRP、ESR、PLT、SOD、CCP-AB、IgG存在明显关联关系,置信度均在70%以上。无外用药组和有外用药组治疗后RF、HsCRP、ESR、CCP-AB、IgG、C3均较治疗前有所降低,差异具有统计学意义(P0.05或P0.01)。有外用药组治疗后CCP-AB、IgG、PLT较无外用药降低显著,SOD较治疗前明显升高,差异有统计学意义(P0.05或P0.01)。结论:中医内外合治可有效改善湿热痹阻型RA患者免疫炎症、氧化应激指标,其作用于免疫炎症、氧化应激机制还有待于进一步研究。
[Abstract]:Objective: to analyze the effect of traditional Chinese medicine and external medicine on immune inflammation and oxidative stress in patients with rheumatoid arthritis treated by rheumatology department of our hospital by using association rules and statistical methods, and to explore the scientific nature of internal and external treatment of rheumatoid arthritis. To provide the basis for optimizing the treatment plan. Methods: the medical records of patients with rheumatoid arthritis in the Department of Rheumatology of the first affiliated Hospital of Anhui University of traditional Chinese Medicine from June 2012 to October 2015 were analyzed. SPSS 17.0 and SPSS Clementine 12.0 software Aprior module were used to analyze the relationship between oral and external administration of traditional Chinese medicine and the changes of immune inflammation and oxidative stress. Results: the syndrome differentiation of RA patients with dampness and heat obstruction can be divided into four categories, and the highest frequency of medicine is invigorating spleen and removing dampness. Take Chinese herbal medicine Weiling Xian, Chen Pei, Scutellaria baicalensis, Scutellaria chinensis, Chinese yam, Plantago chinensis, White Flower tongue, Safflower, Plantago, Poria cocos, Taraxacum, Poria cocos, Coix seed, etc., and external medicine Furong ointment, There was a significant correlation between Xiaoyu Jiegu Powder and CCP-ABN IgG in RFHs-CRPX ESRP PLT and SODX, and the confidence was over 70%. After treatment, RFHsCRPER-ESR-CCP-ABP- IgGG _ 3 in the non-foreign drug group and the external drug group were lower than those before treatment, the difference was statistically significant (P0.05 or P0.01). After treatment, CCP-ABN IgGG PLT decreased significantly and SOD increased significantly (P0.05 or P0.01) in the treated group. Conclusion: internal and external treatment of TCM can effectively improve the immune inflammation and oxidative stress index in RA patients with damp-heat arthralgia. The mechanism of oxidative stress remains to be further studied.
【作者单位】：安徽中医药大学研究生院;安徽中医药大学第一附属医院;
【基金】：国家中医药重点学科中医痹病学建设项目(国中医药发[2009]30号) 国家临床重点专科中医风湿病科建设项目(财社[2013]239号) 安徽省重点实验室建设项目(1306c083035) 国家科技支撑计划课题(2012BA126B02) 安徽省重点实验室:现代中医内科应用基础与开发研究(1606c08238) 国家自然基金青年项目(81403388) 安徽省自然基金项目(1508085QH159) 安徽中医学院科技创新团队项目(2010TD005) 安徽中医药大学校级基金(2014qn025)
【分类号】：R259

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