茵陈玉露饮联合熊去氧胆酸治疗原发性胆汁性胆管炎的临床研究

发布时间：2018-07-03 04:38

  本文选题：原发性胆汁性胆管炎 + 茵陈玉露饮　； 参考：《南京中医药大学》2017年硕士论文

【摘要】：目的:观察茵陈玉露饮联合熊去氧胆酸治疗原发性胆汁性胆管炎(primary biliary cirrhosis,PBC)的临床疗效并探讨其组方原理。方法:病例来源于2015年3月—2016年12月期间就诊于江苏省中医院感染科门诊,且符合入选标准的56例原发性胆汁性胆管炎患者。将患者分为对照组和治疗组各28例,对照组单独使用熊去氧胆酸(Ursodeoxy cholic acide,UDCA),治疗组在对照组的基础上予茵陈玉露饮治疗,3个月为1疗程,共观察2个疗程。在治疗前及治疗3个月后、6个月后分别记录两组患者的症状体征、肝功能各项指标,并观察不良反应。采用SPSS19.0软件进行统计分析,设P0.05为差异有统计学意义。结果:(1)中医证候比较:治疗3个月后,两组证候总积分比较,差异有统计学意义(P0.05);症状体征比较,仅胁痛有统计学意义(P0.05)。治疗6个月后,两组证候总积分比较,差异有显著意义(P0.01);症状体征比较,在胁痛、乏力、瘙痒、口干、纳差方面,差异有统计学意义(P0.05)。治疗组中医证候总有效率82.15%,优于对照组46.43%,差异有统计学意义(P0.05)。(2)肝功能比较:治疗3个月后,两组病例的ALT、ALP、GGT、TBIL、DBIL与治疗前相比均有统计学意义(P0.05);组间比较无统计学意义。治疗6个月后,两组病例的AST、ALT、ALP、GGT、TBIL、DBIL与治疗前相比均有统计学意义(P0.05);组间比较AST、ALP有统计学意义(P0.05),说明治疗组在AST、ALP上改善优于对照组。结论:茵陈玉露饮联合熊去氧胆酸能改善PBC患者的临床症状,包括胁痛、乏力、瘙痒、口干、纳差;并能改善患者的肝功能指标,尤其在AST、ALP方面有优势;且安全性良好,值得进一步推广研究。
[Abstract]:Objective: to observe the clinical effect of Yinchenyu Luyin combined with ursodeoxycholic acid in the treatment of (primary biliary cirrhosis PBC. Methods: from March 2015 to December 2016, 56 patients with primary biliary cholangitis were admitted to Jiangsu Provincial Hospital of traditional Chinese Medicine. The patients were divided into control group (n = 28) and treatment group (n = 28). The control group was treated with Ursodeoxy cholic acidecholic acid (UDCA) alone. The treatment group was treated with Yinchen Yulu decoction on the basis of the control group. The symptoms and signs, liver function and adverse reactions were recorded before and after treatment for 3 months and 6 months respectively. SPSS 19.0 software was used to carry out statistical analysis, set P0.05 as the difference was statistically significant. Results: (1) comparison of TCM syndromes: after 3 months of treatment, there was a significant difference between the two groups in the total score of syndromes (P0.05); symptoms and signs of comparison, only hypochondriac pain had statistical significance (P0.05). After 6 months of treatment, there was significant difference between the two groups in the total score of syndromes (P0.01); the comparison of symptoms and signs in hypochondriac pain, fatigue, pruritus, dry mouth, anorexia, the difference was statistically significant (P0.05). The total effective rate of TCM syndromes in the treatment group was 82.15, which was better than that in the control group (46.43). The difference was statistically significant (P0.05). (2). After 3 months of treatment, the two groups had statistical significance compared with those before treatment (P0.05). After 6 months of treatment, there were significant differences between the two groups (P0.05) in the treatment of ASTT ALP GGTT TILB DBIL and between the two groups (P0.05), indicating that the treatment group was better than the control group in the improvement of ASTT ALP. Conclusion: Yinchenyu Luyin combined with ursodeoxycholic acid can improve the clinical symptoms of PBC patients, including hypochondriac pain, fatigue, itching, dry mouth and poor anorexia, and can improve the liver function, especially in AST ALP, and has good safety. It is worth further popularizing research.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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