高血压对肾虚痰瘀型血管性认知功能障碍患者影响的临床研究

发布时间：2018-07-05 10:41

本文选题：高血压 + 肾虚痰瘀　；参考：《南京中医药大学》2016年硕士论文

【摘要】：研究目的：研究高血压对肾虚痰瘀型VCI患者的影响。研究方法：根据血管性认知功能障碍的诊断标准以及肾虚痰瘀中医证型的诊断标准,在江苏省中医院门诊、住院部以及南京市多个社区卫生服务中心,筛选出160例符合条件的血管性认知功能障碍的患者,根据是否患有高血压病分为两组,即有高血压病组(HBP+VCI组)80例,无高血压病组(VCI组)80例,收集入组患者的基本信息,包括性别、年龄、受教育程度、既往史、脑血管病程等情况,予MoCa和CDR量表评估认知功能。所有数据采用SPASS21.0软件进行卡方检验、单因素方差分析等。研究结果：经统计学方法检验,两组患者在性别、年龄、病史、脑血管病程、文化程度等方面无统计学差异,比较两组患者MoCA水平,VCI组22.013±2.588,HBP+VCI组20.338±4.305,p值0.015,根据血压水平分组,1级HBP+VCI组、2级HBP+VCI组、3级HBP+VCI组的MoCA评分分别为21.269±3.560,20.105±3.710,15.444±6.207,组间p值为0.001,最后MoCA量表的各记分项目中,各组间视空间与执行能力、命名、注意、语言、抽象、延迟回忆、定向的p值分别为0.223、0.243、0.008、0.001、0.520、0.006、0.113,不同血压水平的各组间注意、语言及延迟回忆具有统计学差异。研究结论：(1)高血压对肾虚痰瘀型VCI有明显影响；(2)随着血压水平升高,认知功能损害越严重；(3)高血压对认知损害的影响主要体现在注意、语言及延迟回忆等领域。
[Abstract]:Objective: to study the effect of hypertension on VCI patients with kidney deficiency and phlegm stasis. Methods: according to the diagnostic criteria of vascular cognitive dysfunction and traditional Chinese medicine syndromes of kidney deficiency and phlegm stasis, it was found in the outpatient department of Jiangsu traditional Chinese Medicine Hospital and several community health service centers in Nanjing. One hundred and sixty patients with vascular cognitive impairment were selected and divided into two groups according to whether they had hypertension. There were 80 patients with hypertension (HBP VCI group) and 80 patients with no hypertension (VCI group). The basic information of the patients was collected. Gender, age, education, past history and cerebrovascular disease were included. Cognitive function was assessed by MoCa and CDR. All data were checked by SPASS 21.0 software, single factor analysis of variance and so on. Results: there was no statistical difference between the two groups in sex, age, history, cerebrovascular disease course, education and so on. The MoCA scores of the two groups were 21.269 卤3.56020.105 卤3.71015.444 卤6.207, respectively. The scores of MoCA were 21.269 卤3.56020.105 卤3.71015.444 卤6.207 between the two groups, and the P value between the two groups was 0.001. At the end, the scores of MoCA were 0.001 in all the subitems of the scale, and the scores of MoCA were 21.269 卤3.56020.105 卤3.71015.444 卤6.207, respectively. The p values of visual space and executive ability, naming, attention, language, abstractness, delayed recall and orientation were 0.223U 0.243U 0.008 0. 001C 0. 520g 0. 006L 0. 113 respectively. There were statistical differences in attention, language and delayed recall among groups with different blood pressure levels. Conclusion: (1) Hypertension has a significant effect on VCI of kidney deficiency and phlegm stasis type; (2) with the increase of blood pressure, cognitive impairment is more serious; (3) the effect of hypertension on cognitive impairment is mainly reflected in the fields of attention, language and delayed recall.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.7

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