清肺培元颗粒治疗老年肺炎（痰热壅肺证）临床疗效观察

发布时间：2018-07-07 17:02

本文选题：老年肺炎 + 痰热壅肺证　；参考：《河南中医药大学》2016年硕士论文

【摘要】：目的:观察清肺培元颗粒联合西医治疗与单纯西医治疗对老年肺炎痰热壅肺证的临床疗效及实验室指标的影响,探讨清肺培元颗粒治疗老年肺炎痰热壅肺证的临床价值及意义。方法:将符合纳入标准的72例老年肺炎痰热壅肺证随机分为两组,即治疗组清肺培元颗粒加西药36例,对照组清肺培元颗粒模拟剂加西医治疗36例。观察治疗14天,观察治疗后两组对老年肺炎痰热壅肺证患者的临床症状、体征、血常规、C-反应蛋白、降钙素原及影像学的影响。通过比较治疗组和对照组的疗效,评价清肺培元颗粒治疗老年肺炎痰热壅肺证的临床治疗效果。结果:(1)疾病疗效比较:总有效率治疗组高于对照组(P0.05)。(2)证候比较:治疗组有效率高于对照组,两组比较有显著性差异(P0.05)。(3)单项症状比较:治疗组与对照组比较在改善咳嗽、咳痰、喉中痰鸣、气喘等方面有明显优势(P0.05),但在缓解胸闷痛、气短等临床症状无显著优势。(4)治疗组与对照组均可明显降低患者白细胞计数、C反应蛋白、降钙素原数值,有统计学意义(P0.05),但治疗组白细胞计数、C反应蛋白、降钙素原数值下降幅度更明显,与单纯西医治疗组比,有统计学意义(P0.05)。(5)治疗后两组胸部渗出影均有所消散,有统计学意义(P0.05),两组肺部渗出影的消散吸收程度未见明显差异(P0.05)。结论:1.清肺培元颗粒可明显减少老年肺炎痰热壅肺证患者咳嗽的发作次数,咳痰的痰色、痰质、痰量,气喘的程度,与对照组相比治疗组可明显改善临床症状及体征。2.清肺培元颗粒可明显降低老年肺炎痰热壅肺证患者的白细胞计数、C-反应蛋白水平、降钙素原水平,促进肺部炎症病变的改善。
[Abstract]:Objective: to observe the effect of Qingfei Peiyuan granule combined with western medicine and western medicine treatment on the clinical efficacy and laboratory index of phlegm-heat obstruction of lung syndrome in elderly patients with pneumonia, and to explore the clinical value and significance of Qingfei Peiyuan granule in treating senile pneumonia with phlegm-heat obstruction of lung syndrome. Methods: 72 cases of senile pneumonia with phlegm-heat obstruction were randomly divided into two groups: treatment group (36 cases) treated with Qingfei Peiyuan granule plus western medicine, and control group (36 cases) treated with Qingfei Peiyuan granule mimics and western medicine. After 14 days of treatment, the effects of two groups on clinical symptoms, physical signs, blood routine C-reactive protein, procalcitonin and imaging of aged patients with pneumonia with phlegm heat obstruction were observed. By comparing the curative effect between the treatment group and the control group, the clinical therapeutic effect of Qingfei Peiyuan granule in treating senile pneumonia with phlegm heat obstruction of lung syndrome was evaluated. Results: (1) comparison of disease efficacy: the total effective rate was higher in the treatment group than in the control group (P0.05). (2): the effective rate in the treatment group was higher than that in the control group, and there was significant difference between the two groups (P0.05). (3). There were obvious advantages in phlegm and asthma in larynx (P0.05), but there was no significant advantage in relieving chest pain and shortness of breath. (4) both the treatment group and the control group could significantly reduce the number of C-reactive protein (CRP) and procalcitonin (procalcitonin) in leukocyte count. There was significant difference (P0.05), but the leukocyte count and procalcitonin decreased more significantly in the treatment group than in the western medicine group (P0.05). (5). There was statistical significance (P0.05), there was no significant difference in the dissipation and absorption of pulmonary effusion between the two groups (P0.05). Conclusion 1. Qingfei Peiyuan granule can obviously reduce the number of cough attack, sputum color, phlegm quality, phlegm quantity and degree of asthma in aged patients with pneumonia with phlegm heat obstruction. Compared with the control group, the treatment group can obviously improve the clinical symptoms and signs. 2. Qingfei Peiyuan granule could significantly reduce the level of C-reactive protein and procalcitonin in white blood cell count and procalcitonin level of senile pneumonia patients with phlegm-heat obstruction of lung syndrome and promote the improvement of pulmonary inflammation.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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