大株红景天注射液对急性重度一氧化碳中毒患者早期心肌损伤的影响

发布时间：2018-07-08 08:44

本文选题：急性重度一氧化碳中毒 + 大株红景天注射液　；参考：《中医杂志》2017年16期

【摘要】：目的探讨大株红景天注射液对急性重度一氧化碳中毒患者心肌损伤的影响及可能作用机制。方法104例急性重度一氧化碳中毒患者随机分成对照组和治疗组各52例,对照组给予西医常规治疗,治疗组在常规治疗基础上加用大株红景天注射液10 ml静脉滴注,每日1次,治疗2周。两组于治疗前及治疗6 h、14天检测血清心型脂肪酸结合蛋白(H-FABP)、肌红蛋白(Myo)变化,于治疗前后检测患者血一氧化氮(NO)、一氧化氮合酶(NOS)及诱导型一氧化氮合酶(iNOS)水平,记录简易精神状态检查量表(MMSE)评分和左心室射血分数(LVEF)水平变化,观察主要心脏不良事件发生率。采用Pearson相关检验分析患者入院时血清H-FABP与LVEF的相关性。结果两组患者治疗6 h时血清H-FABP和Myo水平较治疗前升高,但治疗组低于对照组(P0.05),两组治疗14天时血清H-FABP和Myo水平均较本组治疗前及治疗6 h降低(P0.05)。治疗后两组血NO、NOS、iNOS水平较治疗前降低(P0.05),LVEF水平和MMSE评分较治疗前升高,治疗后MMSE评分治疗组优于对照组(P0.05)。治疗组主要心脏不良事件发生率明显低于对照组(P0.05)。104例患者入院时血清H-FABP水平与其LVEF呈负相关(r=-0.235,P=0.017)。结论大株红景天注射液能减少急性重度一氧化碳中毒心肌损伤及心脏不良事件的发生,改善心功能,可能与降低血H-FABP、Myo、NO、NOS、iNOS水平有关。
[Abstract]:Objective to investigate the effect and possible mechanism of large strain Rhodiola injection on myocardial injury in patients with acute severe carbon monoxide poisoning. Methods 104 patients with acute severe carbon monoxide poisoning were randomly divided into control group (n = 52) and treatment group (n = 52). The control group was treated with routine western medicine. Treatment 2 weeks. Serum levels of cardiac fatty acid binding protein (H-FABP), myoglobin (Myo), nitric oxide (no), nitric oxide synthase (NOS) and inducible nitric oxide synthase (iNOS) were measured before and after treatment in both groups. The changes of MMSE score and left ventricular ejection fraction (LVEF) were recorded to observe the incidence of major adverse cardiac events. The correlation between serum H-FABP and LVEF was analyzed by Pearson correlation test. Results the levels of serum H-FABP and Myo in the two groups increased at 6 h after treatment, but were lower in the treatment group than in the control group (P0.05), and the levels of H-FABP and Myo in the two groups decreased at 14 days after treatment (P0.05). After treatment, the levels of NOSN iNOS in the two groups were lower than those before treatment (P0.05) and the scores of LVEF and MMSE were higher in the treatment group than in the control group (P0.05). The incidence of major adverse cardiac events in the treatment group was significantly lower than that in the control group (P0.05). There was a negative correlation between the serum H-FABP level and LVEF in 104 patients (r = 0.235). Conclusion large strain Rhodiola injection can reduce myocardial injury and adverse cardiac events in acute severe carbon monoxide poisoning, and improve cardiac function, which may be related to the decrease of serum H-FABP- Myotropium novo NOSINOS level in patients with acute carbon monoxide poisoning.
【作者单位】：河北医科大学附属哈励逊国际和平医院;
【基金】：衡水市科学技术研究与发展计划项目(201401Z)
【分类号】：R259

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