膈下逐瘀汤对子宫不规律出血患者血清炎症因子及HMBG1水平影响研究

发布时间：2018-07-15 11:20

【摘要】：目的:探讨膈下逐瘀汤对子宫不规律出血患者血清炎症因子及HMBG1水平影响。方法:收集医院妇科收治的子宫不规律出血患者64例,随机分为试验组和对照组,各32例。对照组予以达那唑胶囊400~800mg,每日1次/d;试验组在对照组的基础上予以膈下逐瘀汤1剂/d,两组患者均连续治疗3个月。治疗结束后,比较患者临床疗效、性激素水平、血清炎症因子、血清基质金属蛋白酶-9、金属蛋白酶组织抑制因子-2、高迁移率族蛋白1以及不良反应发生情况。结果:治疗后与对照组总有效率68.75%相比,试验组临床总有效率为90.63%较高(P0.05)。治疗后两两组卵泡刺激素、促黄体生成素、雌二醇、血清孕酮以及泌乳素水平降低(P0.05);与对照组相比,试验组卵泡刺激素、促黄体生成素、雌二醇、血清孕酮以及泌乳素水平较低(P0.05)。两组血清基质金属蛋白酶-9、金属蛋白酶组织抑制因子-2以及高迁移率族蛋白1水平降低(P0.05);与对照组相比,试验组血清基质金属蛋白酶-9、金属蛋白酶组织抑制因子-2以及高迁移率族蛋白1较低(P0.05)。两组白介素-6以及肿瘤坏死因子α水平降低(P0.05);与对照组相比,试验组白介素-6以及肿瘤坏死因子α较低(P0.05),两组不良反应比较,差异无统计学意义(P0.05)。结论:膈下逐瘀汤对子宫不规律出血的疗效显著,能够抑制炎症反应,下调HMBG1水平,安全性较高,适宜临床应用推广。
[Abstract]:Objective: to investigate the effect of Gexiazhuyu decoction on serum inflammatory factors and HMBG1 levels in patients with irregular uterine bleeding. Methods: 64 patients with irregular uterine bleeding were randomly divided into experimental group and control group, 32 cases in each group. The control group was given Danazol capsule 400 mg / d once a day, and the experimental group was given one dose of Gexia Zhuyu decoction on the basis of the control group. The patients in both groups were treated continuously for 3 months. After treatment, the clinical efficacy, sex hormone level, serum inflammatory factor, serum matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-2, high mobility group protein-1 and adverse reactions were compared. Results: compared with the control group, the total effective rate of the experimental group was 90.63% (P 0.05). The levels of follicle stimulating hormone, luteinizing hormone, estradiol, serum progesterone and prolactin were decreased in two groups after treatment (P0.05). Serum progesterone and prolactin levels were lower (P0.05). The levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-2 and high mobility group protein-1 were decreased in both groups (P0.05). The serum levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase -2 and high mobility group protein 1 in the experimental group were lower than those in the control group (P0.05). The levels of interleukin -6 and tumor necrosis factor 伪 decreased in the two groups (P0.05); compared with the control group, the levels of interleukin -6 and tumor necrosis factor 伪 were lower in the experimental group (P0.05), and there was no significant difference in adverse reactions between the two groups (P0.05). Conclusion: Gexiazhuyu decoction has a significant effect on irregular uterine bleeding and can inhibit inflammation and down-regulate HMBG1 level. It is safe and suitable for clinical application.
【作者单位】：浙江省立同德医院妇科;浙江大学医学院附属第二医院生殖医学科;
【基金】：浙江省医药卫生一般研究计划项目(2011KYA104)
【分类号】：R271.9

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