血清中HSP70-2及TLR-4的含量与气阴两虚型老年房颤患者的相关性研究

发布时间：2018-07-15 14:26

【摘要】：目的:探讨HSP70-2及TLR-4在气阴两虚型房颤的发生和维持中的作用及临床意义。材料与方法:选入三个年龄段的房颤患者(气阴两虚型)共90例,分别为A组(60-69岁),B组(70-79岁),C组(80-89岁),正常对照组30例。取空腹静脉血,用酶联免疫法(ELISA)测定血清中热休克蛋白70-2(HSP70-2)和TLR-4的含量,比较各个年龄组房颤与正常组患者血清中HSP70-2和TLR-4的含量。结果:1.A组患者血清中HSP70-2浓度为0.46±0.05ng/L,B组患者血清中HSP70-2浓度为0.45±0.07ng/L,C组患者血清中HSP70-2浓度为0.45±0.05ng/L,正常组患者血清中HSP70-2浓度为0.50±0.03ng/L,三组不同年龄患者血清中HSP70-2浓度与正常对照组血清中HSP70-2浓度差异有统计学意义(P0.05),三组不同年龄组房颤患者组间比较无统计学意义(P0.05)。2.A组患者血清中TLR-4浓度为0.47±0.06 ng/ml,B组患者血清中TLR-4浓度为0.46±0.06 ng/ml,C组患者血清中TLR-4浓度为0.44±0.04 ng/ml,正常组患者血清中TLR-4浓度为0.42±0.05 ng/ml,A组、B组患者血清中TLR-4浓度与正常对照组血清中TLR-4浓度差异有统计学意义(P0.05),C组无统计学意义(P0.05),不同年龄组房颤患者组间比较无统计学意义(P0.05)。3.正常组患者血清中HSP70-2的含量与TLR-4的含量呈负相关(r=-0.683,P0.05);房颤患者血清中HSP70-2的含量与TLR-4的含量呈正相关(r=0.292,P0.05)。结论:1.房颤患者血清中HSP70-2、TLR-4的浓度与对照组患者血清中HSP70-2、TLR-4的浓度相比较有显著差异,老年患者血清中HSP70-2、TLR-4的表达水平对房颤的发生和维持有重要影响。2.HSP70-2的含量与TLR-4的含量有相关性,提示其可能共同参与了房颤的发生发展过程。
[Abstract]:Objective: To investigate the role and clinical significance of HSP70-2 and TLR-4 in the occurrence and maintenance of Qi and yin deficiency type atrial fibrillation. Materials and methods: 90 patients (60-69 years old), group B (70-79 years old), group C (80-89 years old) and 30 cases of normal control group were selected into three age groups of atrial fibrillation (60-69 years old), and 30 cases in normal control group were taken to take the fasting venous blood and enzyme linked immunoassay (ELISA). The content of heat shock protein 70-2 (HSP70-2) and TLR-4 in serum was determined. The content of HSP70-2 and TLR-4 in serum of patients with atrial fibrillation and normal group was compared. Results: the concentration of HSP70-2 in serum of patients in group 1.A was 0.46 + 0.05ng/L, and the concentration of HSP70-2 in the serum of group B was 0.45 + 0.07ng/L, and the concentration of HSP70-2 in the serum of C group was 0.45 +. The concentration of HSP70-2 in the serum of the patients in the normal group was 0.50 + 0.03ng/L. The concentration of HSP70-2 in the serum of three groups of age patients and the serum HSP70-2 concentration in the normal control group were statistically significant (P0.05). There was no significant difference between the three groups of age groups with atrial fibrillation (P0.05) the serum TLR-4 concentration was 0.47 + 0.06 ng/ml in the group of.2.A group, and the B group was in the B group. The serum concentration of TLR-4 was 0.46 + 0.06 ng/ml, and the serum concentration of TLR-4 in the group C was 0.44 + 0.04 ng/ml, and the serum TLR-4 concentration in the normal group was 0.42 + 0.05 ng/ml. The serum TLR-4 concentration in the group of A and the group B was statistically significant (P0.05) in the serum of the normal control group. There was no statistical significance between groups of patients with atrial fibrillation (P0.05) the content of HSP70-2 in serum of patients with.3. normal group was negatively correlated with the content of TLR-4 (r=-0.683, P0.05). The content of HSP70-2 in serum of patients with atrial fibrillation was positively correlated with the content of TLR-4 (r=0.292, P0.05). Conclusion: 1. patients with atrial fibrillation were serum HSP70-2, the concentration of TLR-4 and the serum of control patients There is a significant difference in the concentration of HSP70-2 and TLR-4. The expression level of HSP70-2 and TLR-4 in the serum of the elderly patients has an important influence on the occurrence and maintenance of atrial fibrillation. The content of.2.HSP70-2 is related to the content of TLR-4, suggesting that it may be involved in the development of atrial fibrillation.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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