清热化瘀方治疗围绝经期血热夹瘀型崩漏的临床观察疗效

发布时间：2018-07-17 05:54

【摘要】：目的:观察清热化瘀方治疗血热夹瘀型围绝经期崩漏的止血疗效,并探讨本方止血机理。方法:收录40例符合标准的血热夹瘀型围绝经期崩漏患者,随机分为治疗组(20例)、对照组(20例)。治疗组采用口服清热化瘀汤,对照组采用口服三七血伤宁胶囊。7天为一个疗程,观察并分析治疗组与对照组的临床止血疗效,并对治疗前后的总体疗效、中医证候积分、血红蛋白、PT、APTT的改变状况。结果:.(1)总体疗效评定:治疗组20例患者,痊愈10例,占50%;显效6例,占30%;有效3例,占15%;无效1例,占5%;总有效率95%;对照组20例患者,痊愈3例,占15%;显效4例,占20%;有效6例,占30%;无效7例,占35%;总有效率65%。治疗组及对照组的总体疗效数值经过比较P0.05,具有统计学意义,且治疗组疗效优于对照组疗效。(2)止血疗效评定:治疗组与对照组用药后的止血天数疗效比较中,治疗组的总有效率为95.00%,其中速效6例,显效11例,有效2例,无效1例;对照组的总有效率为65.0%,其中速效1例,显效4例,有效8例,无效7例。两组止血疗效数值比较P0.05,具有统计学意义,且治疗组疗效优于对照组疗效。(3)治疗前后中医积分:治疗组与对照组在中医临床症状治疗中,治疗组治疗后与治疗前相比较P0.01,治疗组治疗后与对照组治疗后相比较P0.01,比较具有显著性差异,说明治疗组疗效优于对照组。(4)血红蛋白、APTT、PT:治疗组于治疗后血红蛋白含量提升,APTT和PT时间缩短,比较治疗前后的数值,经t检验P0.01,说明纠正贫血、缩短出凝血时间上治疗组优于对照组。结论:血热夹瘀型围绝经期崩漏患者通过清热化瘀方取得优良的止血疗效,并对其伴随的不适症状有所改善,同时对于纠正血红蛋白以及缩短出凝血时间还有显著的改善,收录患者在治疗期间以及治疗后皆未有明显不良反应。采用中医辩证施治治疗本病有一定的优势所在,值得在临床上更进一步进行推广以及研究。
[Abstract]:Objective: to observe the hemostatic effect of Qingre Huayu recipe in treating peri-menopausal leakage of blood-heat and stasis type, and to explore its hemostatic mechanism. Methods: 40 cases of peri-menopausal leakage with blood heat and stasis were randomly divided into treatment group (20 cases) and control group (20 cases). The treatment group was treated with Qingre Huayu decoction and the control group was treated with Sanqi Xueshang Ning capsule for a course of 7 days. The clinical hemostatic effect of the treatment group and the control group was observed and analyzed, and the overall curative effect before and after treatment and the TCM syndromes integral were observed and analyzed. The change of APTT in PTT of hemoglobin. Results: (1) the overall curative effect evaluation: in the treatment group, 20 cases were cured (10 cases, 50 cases); 6 cases were markedly effective (30 cases); 3 cases were effective (15 cases); 1 case was ineffective (5 cases); the total effective rate was 952%; in the control group, 20 cases were cured, 3 cases (15%) were cured; 4 cases were remarkable effect, It was effective in 6 cases (30%), ineffective in 7 cases (35%), and total effective rate in 65 cases. The total curative effect of the treatment group and the control group was compared with that of the control group (P0.05), and the curative effect of the treatment group was better than that of the control group. (2) the evaluation of hemostatic effect: in the comparison of the days of hemostasis between the treatment group and the control group, The total effective rate was 95.00 in the treatment group, including 6 cases of quick effect, 11 cases of remarkable effect, 2 cases of effective and 1 case of ineffectiveness, while the total effective rate of control group was 65.0%, of which 1 case was quick, 4 cases were effective, 8 cases were effective and 7 cases were ineffective. The value of hemostatic effect in the two groups was significantly higher than that in the control group (P 0.05). (3) Chinese medicine integral before and after treatment: the treatment group and the control group were treated with traditional Chinese medicine (TCM) clinical symptoms. There was a significant difference between the treatment group and the control group after treatment (P 0.01), and the treatment group (P 0.01) after treatment compared with the control group (P 0.01), there was significant difference between the treatment group and the control group after treatment. It showed that the curative effect of the treatment group was better than that of the control group. (4) the hemoglobin content in the treatment group was increased after treatment and the time of APTT and PT was shortened. The values before and after treatment were compared, and the results of t test (P0.01) showed that the anemia was corrected. The treatment group was superior to the control group in shortening the clotting time. Conclusion: the patients with peri-menopausal collapse of blood heat and blood stasis can obtain excellent hemostatic effect by Qingre Huayu prescription, and improve the associated symptoms, at the same time, it can also improve the hemoglobin and shorten the time of blood clotting. There were no significant adverse reactions during and after treatment. There are some advantages in the treatment of this disease by dialectical treatment of traditional Chinese medicine, which is worth further popularizing and researching in clinic.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.12

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