基于前瞻性注册登记研究的风热犯肺证4项炎症指标特征分析

发布时间：2018-07-20 12:56

【摘要】：目的:通过对肺部和呼吸道感染风热犯肺证与痰热蕴肺证患者IL-1β、IL-4、IL-6、IL-8血液样本检测指标的特征分析,探求外感风热是否区别于痰热成为导致4项指标变化的本质原因。方法:采用前瞻性注册登记式研究方法,分析180例肺部及呼吸道感染患者的临床信息,采用倾向性评分方法控制混杂因素,通过对肺部和呼吸道感染风热犯肺证与痰热蕴肺证患者血液样本的炎性指标进行分析,探求外感风热是否区别于痰热而成为影响4项白介素指标变化的本质因素。结果:风热犯肺较痰热蕴肺对IL-1β、IL-4、IL-6、IL-8指标的影响皆有显著意义。结论:现有数据显示,与痰热比较外感风热是影响IL-1β、IL-4、IL-6、IL-8的本质因素,但还需实验室基础研究及大样本前瞻性临床研究进一步证实。
[Abstract]:Objective: to analyze the characteristics of blood samples of IL-1 尾 IL-4 and IL-6 + IL-8 in patients with lung syndrome and phlegm heat accumulation syndrome of lung and respiratory tract infection, and to find out whether the difference between exogenous wind heat and phlegm heat is the essential reason for the change of the four indexes. Methods: the clinical information of 180 patients with pulmonary and respiratory tract infection was analyzed by prospective registration method, and the confounding factors were controlled by tendency score. By analyzing the inflammatory indexes of blood samples of patients with lung syndrome and phlegm heat accumulation syndrome of lung and respiratory tract infection, the author explored whether the extrinsic wind heat was different from phlegm heat and became the essential factor influencing the change of four interleukin indexes. Results: the influence of wind heat invading lung than phlegm heat accumulating lung on IL-8 index of IL-1 尾-IL-4 and IL-6 + was significantly higher than that of phlegm heat accumulation. Conclusion: compared with phlegm heat, exogenous wind heat is the essential factor affecting IL-6 and IL-8, but it needs further confirmation from laboratory basic research and large prospective clinical study.
【作者单位】：中国中医科学院中医临床基础医学研究所;北京市昌平区中西医结合医院;沈阳市骨科医院;中国人民大学;
【基金】：国家自然科学基金面上项目(81473798)-主动监测与网络靶标预测多维涌现的上市后中药注射剂过敏反应机制研究中央级公益性科研院所基本业务费项目(Z0406)-循证中医药证据核心科学问题深化研究;中央级公益性科研院所基本业务费项目(PY1303)-中药上市后临床再评价关键技术创新团队国家中医药管理局中医药行业科研专项(200907001-5-6)-感染性疾病常用中药注射剂临床安全性监测及过敏反应发生机理研究
【分类号】：R259

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