白牛宣肺汤治疗感染后咳嗽的随机双盲对照临床研究

发布时间：2018-07-21 18:30

【摘要】：目的评价白牛宣肺汤治疗感染后咳嗽的临床疗效及安全性。方法将70例感染后咳嗽内有郁热、外邪未尽证患者随机分为中药组和对照组各35例,中药组采用白牛宣肺汤和孟鲁司特钠片模拟剂口服,对照组采用白牛宣肺汤模拟剂和孟鲁司特钠片口服,疗程均为7天,随访7天。随访结束后评价临床疗效及安全性。结果中药组日间咳嗽症状评分、夜间咳嗽症状评分及视觉模拟咳嗽症状积分(VAS积分)均较治疗前明显降低(P0.001),且日间咳嗽评分、VAS积分均较对照组降低显著(P0.05)。中药组临床疗效愈显率为90.91%,对照组为62.50%,中药组明显高于对照组(P0.05)。中药组治疗后综合症状评分较治疗前明显降低(P0.001),且中药组较对照组降低更显著(P0.01)。中药组止咳起效时间、咳嗽缓解时间和咳嗽痊愈时间均明显短于对照组(P0.01)。中药组复发率为12.50%,对照组为40.00%,中药组复发率明显低于对照组(P0.05)。两组患者均未出现不良事件。结论白牛宣肺汤治疗感染后咳嗽临床疗效显著,且复发率低、安全性好。
[Abstract]:Objective to evaluate the clinical efficacy and safety of Bai Niu Xuan Fei Decoction in the treatment of post infection cough. Methods 70 patients with coughing after infection were randomly divided into Chinese medicine group and control group in 35 cases. The Chinese medicine group was treated with Bai Niu Xuan lung soup and Montelukast Sodium Tablets analogue, and the control group adopted Bai Niu Xuan Fei soup analogue and montelukast. The course of the treatment was 7 days, followed up for 7 days. After the follow-up, the clinical efficacy and safety were evaluated. Results the score of cough symptoms, the score of coughing symptoms at night and the score of visual analogue cough symptom (VAS score) were significantly lower than before the treatment (P0.001), and the VAS score of the day was significantly lower than that of the control group (P0.05). The effective rate of the clinical efficacy of the Chinese medicine group was 90.91%, the control group was 62.50%, the traditional Chinese medicine group was significantly higher than the control group (P0.05). The comprehensive symptom score of the Chinese medicine group was significantly lower than that before the treatment (P0.001), and the Chinese traditional medicine group was significantly lower than the control group (P0.01). The time of cough onset, the time of cough relief and the recovery time of coughing were significantly shorter than those of the Chinese traditional medicine group. The recurrence rate of the Chinese medicine group was 12.50%, the control group was 40%, the recurrence rate of the Chinese medicine group was significantly lower than that of the control group (P0.05). The two groups had no adverse events. Conclusion Bai Niu Xuan Fei decoction has a significant clinical effect in the treatment of post infection coughing, and the recurrence rate is low and the safety is good.
【作者单位】：中国中医科学院广安门医院;
【基金】：中国中医科学院基本科研业务自主选题课题(ZZ0908006)
【分类号】：R259

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