心脏彩色多普勒超声评价压力负荷超载诱导的舒张性心力衰竭及益气温阳中药的干预作用
发布时间：2018-07-22 11:32
【摘要】：目的:通过心脏彩色多普勒超声评价压力负荷超载诱导的舒张性心力衰竭及益气温阳中药的干预作用。方法:清洁级雄性Wistar大鼠40只,随机选取10只为假手术组,余30只腹主动脉缩窄术后,随机分为模型组、中药组、缬沙坦组,每组10只。造模后8周开始药物干预,共干预16周。观察药物干预对心脏彩色多普勒超声的影响。结果:1.心肌形态测量学:造模24周后,模型组大鼠CMI、LVMI明显增加(P0.05),中药组的CMI、LVMI和模型组相比差异无统计学意义(P0.05),缬沙坦组CMI、LVMI和模型组相比差异有统计学意义(P0.05),中药组CMI、LVMI与西药组相比差异无统计学意义(P0.05)。2.M型超声心动图:(1)造模24周后,模型组大鼠IVSd显著增高(P0.05),中药组IVSd与模型组相比有减小趋势,差异无统计学意义(P=0.069),缬沙坦组IVSd与模型组相比明显减小(P0.05),中药组IVSd与缬沙坦组相比差异无统计学意义(P0.05)。(2)造模24周后,模型组大鼠LV Mass增大(P0.05),中药组LV Mass与模型组相比有统计学差异(P0.05),缬沙坦组LV Mass与模型组相比差异有统计学意义(P0.05),中药组LV Mass与缬沙坦组相比差异无统计学意义(P=NS)。(3)造模24周后,模型组大鼠LVIDd明显增大(P0.05),中药组LVIDd较模型组减小(P0.05),缬沙坦组LVIDd和模型组比较差异没有统计学意义(P0.05),中药组LVIDd与缬沙坦组相比差异无统计学意义(P0.05)。(4)造模24周后,模型组大鼠EF、FS降低,但差异无统计学意义(P0.05),中药组、缬沙坦组和模型组相比差异无统计学意义(P0.05,P0.05),中药组和缬沙坦组相比差异无统计学意义(P0.05)。3.心脏彩色血流多普勒超声:(1)造模24周后,模型组E峰显著减小(P0.05);中药组E峰较模型组增大(P0.05);缬沙坦组和模型组比较差异无统计学意义(P0.05),中药组与缬沙坦组相比差异无统计学意义(P0.05)。(2)模型组E/A比值显著降低(P0.05),中药组E/A比值较模型组显著提高(P0.05),缬沙坦组E/A比值和模型组相比差异无统计学意义(P0.05),中药组E/A比值与缬沙坦组相比差异无统计学意义(P0.05)。4.血流动力学:(1)造模24周后,模型组SAP明显升高(P0.05),中药组SAP较模型组降低(P0.05),缬沙坦组SAP较模型组降低(P0.05),中药组SAP与缬沙坦组相比差异无统计学意义(P0.05)。(2)造模24周后,模型组LVSP明显升高(P0.05),中药组LVSP较模型组降低(P0.05),缬沙坦组LVSP较模型组降低(P0.05),中药组LVSP与缬沙坦组相比差异无统计学意义(P0.05)。(3)造模24周后,模型组LVEDP明显升高(P0.05),中药组LVEDP较模型组降低(P0.05),缬沙坦组LVEDP较模型组降低(P0.05),中药组LVEDP与缬沙坦组相比差异无统计学意义(P0.05)。结论:心脏彩色多普勒超声是评价压力负荷超载诱导的舒张性心力衰竭的有效方法,益气温阳中药可有效改善压力负荷超载诱导的舒张性心力衰竭。
[Abstract]:Objective: To evaluate the intervention effect of pressure overload induced diastolic heart failure and Yiqi Wenyang traditional Chinese medicine by color Doppler echocardiography. Methods: 40 clean male Wistar rats were randomly selected and 10 were randomly selected as sham operation group and the remaining 30 abdominal aorta coarctation were randomly divided into model group, Chinese medicine group and valsartan group, 10 rats in each group. The drug intervention began 8 weeks after 8 weeks. The effect of drug intervention on color Doppler echocardiography was observed. Results: 1. myocardial morphometry: after 24 weeks of modeling, the model group rats were significantly increased (P0.05), CMI, LVMI and model groups were not statistically significant (P0.05), and the Valsartan group CMI, LVMI and model groups compared with the model group (P0.05). The difference was statistically significant (P0.05). There was no significant difference between CMI and LVMI in Chinese medicine group (P0.05).2.M type echocardiography: (1) after 24 weeks of modeling, IVSd significantly increased in model group (P0.05), and there was no significant difference between the traditional Chinese medicine group IVSd and model group (P=0.069), and the Valsartan group IVSd was more obvious than the model group. There was no significant difference in the difference between IVSd and valsartan group (P0.05). (2) after 24 weeks of modeling, the LV Mass in the model group increased (P0.05). The LV Mass in the Chinese medicine group was significantly different from the model group (P0.05), and the LV Mass in the Valsartan group had a significant difference compared with the model group (P0.05), the Chinese medicine group and the Valsartan group There was no significant difference (P=NS). (3) after 24 weeks of modeling, the model group LVIDd significantly increased (P0.05), the traditional Chinese medicine group LVIDd was less than the model group (P0.05), and there was no statistical difference between the Valsartan group LVIDd and the model group (P0.05), and there was no statistical difference between the traditional Chinese medicine group LVIDd and valsartan group (P0.05). (4) the model group was larger than the model group after 24 weeks. EF, FS decreased, but the difference was not statistically significant (P0.05). There was no significant difference between the traditional Chinese medicine group and the Valsartan group (P0.05, P0.05). There was no significant difference between the Chinese medicine group and the Valsartan group (P0.05).3. heart color Doppler ultrasound: (1) the model group E peak decreased significantly (P0.05) after 24 weeks of modeling, and the E peak of the Chinese medicine group was compared with the model. There was no significant difference between the Valsartan group and the model group (P0.05). There was no significant difference between the Valsartan group and the Valsartan group (P0.05). (2) the E/A ratio in the model group was significantly decreased (P0.05), and the E/A ratio in the Chinese medicine group was significantly higher than that in the model group (P0.05), and there was no statistical difference between the Valsartan group and the model group (P0.). 05) there was no significant difference between the E/A ratio of the Chinese medicine group and the Valsartan group (P0.05).4. hemodynamics: (1) after 24 weeks, the SAP of the model group was significantly higher (P0.05), the SAP in the Chinese medicine group was lower than the model group (P0.05), and the SAP of the Valsartan group was lower than the model group (P0.05). There was no significant difference between the Valsartan group and the Valsartan group (P0.05). (2) the model 24 was 24. After week, the LVSP in the model group increased significantly (P0.05), the LVSP of the Chinese medicine group was lower than the model group (P0.05), and the LVSP in the Valsartan group was lower than the model group (P0.05). There was no significant difference between the Valsartan group and the Valsartan group (P0.05). (3) after 24 weeks of modeling, the model group LVEDP obviously increased (P0.05), the LVEDP of the Chinese medicine group was lower than the model group (P0.05), and the Valsartan group was more than the model group. The model group decreased (P0.05). There was no significant difference between the LVEDP and the Valsartan group (P0.05). Conclusion: color Doppler echocardiography is an effective method to evaluate the diastolic heart failure induced by overload of pressure load. The Yiqi Wenyang Chinese medicine can effectively improve the diastolic heart failure induced by overload of pressure load.
【作者单位】： 上海中医药大学附属曙光医院;上海中医药大学附属第七人民医院;上海中医药大学附属上海市中医医院;
【基金】：国家自然科学基金项目(81102671) 上海市高级中西医结合人才培养项目(ZYSNXD012-RC-ZXY002)
【分类号】：R259
本文编号：2137304
[Abstract]:Objective: To evaluate the intervention effect of pressure overload induced diastolic heart failure and Yiqi Wenyang traditional Chinese medicine by color Doppler echocardiography. Methods: 40 clean male Wistar rats were randomly selected and 10 were randomly selected as sham operation group and the remaining 30 abdominal aorta coarctation were randomly divided into model group, Chinese medicine group and valsartan group, 10 rats in each group. The drug intervention began 8 weeks after 8 weeks. The effect of drug intervention on color Doppler echocardiography was observed. Results: 1. myocardial morphometry: after 24 weeks of modeling, the model group rats were significantly increased (P0.05), CMI, LVMI and model groups were not statistically significant (P0.05), and the Valsartan group CMI, LVMI and model groups compared with the model group (P0.05). The difference was statistically significant (P0.05). There was no significant difference between CMI and LVMI in Chinese medicine group (P0.05).2.M type echocardiography: (1) after 24 weeks of modeling, IVSd significantly increased in model group (P0.05), and there was no significant difference between the traditional Chinese medicine group IVSd and model group (P=0.069), and the Valsartan group IVSd was more obvious than the model group. There was no significant difference in the difference between IVSd and valsartan group (P0.05). (2) after 24 weeks of modeling, the LV Mass in the model group increased (P0.05). The LV Mass in the Chinese medicine group was significantly different from the model group (P0.05), and the LV Mass in the Valsartan group had a significant difference compared with the model group (P0.05), the Chinese medicine group and the Valsartan group There was no significant difference (P=NS). (3) after 24 weeks of modeling, the model group LVIDd significantly increased (P0.05), the traditional Chinese medicine group LVIDd was less than the model group (P0.05), and there was no statistical difference between the Valsartan group LVIDd and the model group (P0.05), and there was no statistical difference between the traditional Chinese medicine group LVIDd and valsartan group (P0.05). (4) the model group was larger than the model group after 24 weeks. EF, FS decreased, but the difference was not statistically significant (P0.05). There was no significant difference between the traditional Chinese medicine group and the Valsartan group (P0.05, P0.05). There was no significant difference between the Chinese medicine group and the Valsartan group (P0.05).3. heart color Doppler ultrasound: (1) the model group E peak decreased significantly (P0.05) after 24 weeks of modeling, and the E peak of the Chinese medicine group was compared with the model. There was no significant difference between the Valsartan group and the model group (P0.05). There was no significant difference between the Valsartan group and the Valsartan group (P0.05). (2) the E/A ratio in the model group was significantly decreased (P0.05), and the E/A ratio in the Chinese medicine group was significantly higher than that in the model group (P0.05), and there was no statistical difference between the Valsartan group and the model group (P0.). 05) there was no significant difference between the E/A ratio of the Chinese medicine group and the Valsartan group (P0.05).4. hemodynamics: (1) after 24 weeks, the SAP of the model group was significantly higher (P0.05), the SAP in the Chinese medicine group was lower than the model group (P0.05), and the SAP of the Valsartan group was lower than the model group (P0.05). There was no significant difference between the Valsartan group and the Valsartan group (P0.05). (2) the model 24 was 24. After week, the LVSP in the model group increased significantly (P0.05), the LVSP of the Chinese medicine group was lower than the model group (P0.05), and the LVSP in the Valsartan group was lower than the model group (P0.05). There was no significant difference between the Valsartan group and the Valsartan group (P0.05). (3) after 24 weeks of modeling, the model group LVEDP obviously increased (P0.05), the LVEDP of the Chinese medicine group was lower than the model group (P0.05), and the Valsartan group was more than the model group. The model group decreased (P0.05). There was no significant difference between the LVEDP and the Valsartan group (P0.05). Conclusion: color Doppler echocardiography is an effective method to evaluate the diastolic heart failure induced by overload of pressure load. The Yiqi Wenyang Chinese medicine can effectively improve the diastolic heart failure induced by overload of pressure load.
【作者单位】： 上海中医药大学附属曙光医院;上海中医药大学附属第七人民医院;上海中医药大学附属上海市中医医院;
【基金】：国家自然科学基金项目(81102671) 上海市高级中西医结合人才培养项目(ZYSNXD012-RC-ZXY002)
【分类号】：R259
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