加味玉屏风散治疗感染后咳嗽（正虚邪恋证）的临床疗效研究

发布时间：2018-07-22 16:16

【摘要】：目的“感染后咳嗽”属中医“外感咳嗽”范畴,部分患者因免疫力低下,素体肺虚而又易复感外邪,正虚邪恋,阴阳失衡导致咳嗽缠绵难愈。朱佳教授以“平补阴阳,固护正气”为基本原则,在“玉屏风散”的基础上临证加减,并运用现代循证医学手段,从多方面评估加味玉屏风散治疗感染后咳嗽(正虚邪恋证)的有效性,为指导临床提供新思路。方法采用随机、平行对照的方式开展临床研究,将受试者随机分为两组,中药组予加味玉屏风散治疗,对照组予孟鲁司特钠(顺尔宁)及美敏伪麻黄液(惠菲宁)治疗,治疗周期为28天,观察一个疗程,以临床症状体征、强迫振荡肺功能检测气道阻力及免疫五项做为观察指标,病例数据均用SPSS20.0软件进行统计学分析。结果收集病例总数为73例,其中中药组41例,对照组32例。中药组92.68%有效,对照组65.63%有效,两组数据经卡方检验P0.05,差异具有统计学意义；中药组能明显降低R5(呼吸道总粘性阻力)、R20(中心气道阻力)、R5-R20(周边气道阻力)、X5(气道弹性阻力),疗效显著优于对照组(P0.05)；中药组能提高患者的免疫球蛋白IgA、IgG、 IgM及补体C3、C4水平,疗效优于对照组(P0.05)。结论加味玉屏风散益气固表,宣肺止咳,清热利咽,能有效缓解临床症状,并且能降低气道阻力,减轻气道炎症,降低气道高反应性,同时增强机体的免疫能力。
[Abstract]:Objective "cough after infection" belongs to the category of "exogenous cough" in TCM. Some patients are prone to recover the external evil, love the deficiency of the positive and the evil, and the imbalance of yin and yang lead to the lingering cough because of low immunity and deficiency of the lung. Professor Zhu Jia, based on the basic principle of "nourishing Yin and Yang and protecting Qi," and on the basis of "Yupingfeng San", adds and subtracts evidence and applies modern evidence-based medicine. To evaluate the effectiveness of Jiawei Yupingfeng Powder in treating cough after infection from many aspects, and to provide a new idea for clinical guidance. Methods A randomized, parallel controlled clinical study was conducted. The subjects were randomly divided into two groups: the traditional Chinese medicine group was treated with modified Yupingfeng powder, the control group was treated with montelukast sodium (Shunerning) and meimin pseudoephedra solution (Huifinin). The treatment period was 28 days. The clinical symptoms and signs, forced oscillatory pulmonary function, airway resistance and immunity were used as the observation indexes. The data of the cases were analyzed by SPSS 20.0 software. Results 73 cases were collected, including 41 cases in TCM group and 32 cases in control group. Chinese medicine group 92.68% effective, control group 65.63% effective, two groups of data by chi-square test P0.05, the difference was statistically significant; Chinese medicine group could significantly reduce R5 (total respiratory tract viscous resistance) and R20 (central airway resistance) and R5-R20 (peripheral airway resistance) X5 (airway elastic resistance), the curative effect was significantly better than the control group (P0.05), the Chinese medicine group could increase the levels of IgG, IgM and complement C _ 3N _ 4 in patients. The curative effect was better than the control group (P0.05). Conclusion the modified Yupingfeng Powder can effectively relieve clinical symptoms, reduce airway resistance, reduce airway inflammation, reduce airway hyperresponsiveness, and enhance the immune ability of the body.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.11

【相似文献】