经前平颗粒治疗PMDD肝气逆证的疗效研究

发布时间：2018-07-23 19:15

【摘要】：目的:研究经前平颗粒对比氟西汀、安慰剂治疗PMDD肝气逆证的疗效,探讨肝主疏泄调畅情志的机理与PMDD病机特点的关系。使遣方用药更具有针对性,证明中医辨证论治思想治疗PMDD肝气逆证的优势,为阐明从肝论治PMDD肝气逆证,提供充分的实验和科学依据。方法:通过临床流行病学调查,筛选55例符合PMDD肝气逆证标准的受试者(18-45岁),进行随机双盲双模拟对照,给予经前平颗粒、氟西汀和安慰剂治疗三个月经周期,根据“症状严重程度每日报告”(DRSP)、“证候严重程度评价表”观察症状变化,采用SPSS17.0对数据进行统计分析,对比三组药物治疗PMDD肝气逆证的疗效。结果:1.从DRSP结果分析:通过病的角度治疗PMDD肝气逆证,氟西汀对大多数症状都有明显缓解作用(P0.01),经前平对部分症状有缓解作用,安慰剂仅对个别症状有缓解作用,说明通过辨病的角度治疗PMDD肝气逆证,氟西汀疗效要优于经前平。2.从证候严重程度测评表结果分析:通过辨证论治的角度治疗PMDD肝气逆证,经前平对PMDD肝气逆证大部分症状及总体治疗具有明显疗效(P0.01),氟西汀对部分精神症状有显著疗效,而安慰剂仅对头胀有一定疗效。表明通过辨证的角度治疗PMDD肝气逆证,经前平疗效要优于氟西汀。结论:通过病的角度和辨证的角度治疗PMDD肝气逆证,经前平和氟西汀疗效不同。通过辨证论治,经前平颗粒可以明显改善PMDD肝气逆证的症状,经前平颗粒是根据PMDD证型肝气逆证研制的中药,体现了中医辨证论治的思想,根据不同的证因证施治,疗效更加显著;证明了从肝论治PMDD的作用机制。氟西汀治疗PMDD没有分证型,降低了治疗PMDD肝气逆证的疗效。但是从辨病的角度分析结果显示,氟西汀效果较显著。安慰剂对PMDD肝气逆证某些症状也有一定疗效。
[Abstract]:Objective: to study the therapeutic effect of Jingqian granule on PMDD with fluoxetine and placebo, and to explore the relationship between the mechanism of liver main dredging and regulating unobstructed emotion and the pathogenesis of PMDD. The purpose of this paper is to provide sufficient experimental and scientific basis for elucidating the treatment of liver qi inverses of PMDD from liver to liver by using Chinese medicine with more pertinence and proving the advantage of TCM dialectical treatment of liver-qi inverses. Methods: through clinical epidemiological investigation, 55 subjects (18-45 years old) who met the criteria of PMDD liver qi converse syndrome were selected and treated with Jingqian granule, fluoxetine and placebo for three menstrual cycles. According to "symptom severity daily report" (DRSP), "syndrome severity evaluation table" observe the symptom change ", use SPSS17.0 to carry on the statistical analysis to the data, compare the curative effect of three groups of drugs to treat the PMDD liver qi inverse syndrome. The result is 1: 1. According to the analysis of DRSP results, fluoxetine can relieve most of the symptoms of PMDD by treating liver qi inverses from the disease angle (P0.01). Jingqian Ping can relieve some symptoms, and placebo can relieve only individual symptoms. It shows that fluoxetine is more effective than Pian Ping. 2. 2 in treating PMDD liver qi inverses by the angle of disease differentiation. According to the results of syndrome severity evaluation table: treatment of PMDD liver qi inverses through syndrome differentiation and treatment, Jing Qianping has obvious curative effect on most symptoms and overall treatment of PMDD liver qi inverses (P0.01), fluoxetine has remarkable curative effect on some mental symptoms. Placebo only has a certain effect on head distension. The results showed that the treatment of PMDD liver qi inverses was superior to fluoxetine in the treatment of syndrome differentiation from the point of view of syndrome differentiation. Conclusion: the curative effect of premenstrual and fluoxetine is different in treating PMDD liver qi converse syndrome from the angle of disease and syndrome differentiation. According to syndrome differentiation and treatment, Jingqian Ping granule can obviously improve the symptoms of PMDD liver-qi inverse syndrome. Jing Qianping granule is a traditional Chinese medicine developed according to PMDD syndrome type liver qi inverse syndrome, which embodies the thought of TCM syndrome differentiation and treatment, and is treated according to different syndromes of syndromes and causes. The curative effect is more remarkable, which proves the mechanism of treating PMDD from liver. Fluoxetine treatment of PMDD has no syndrome type, reducing the treatment of PMDD liver qi syndrome efficacy. However, from the point of view of disease differentiation, fluoxetine is more effective. The placebo also has certain curative effect on some symptoms of PMDD liver qi inverses syndrome.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.115

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