糖尿康片联合六仙饮治疗消渴病（2型糖尿病）气阴两虚证的临床研究
发布时间：2018-07-24 08:47
【摘要】：目的:本课题系统观察糖尿康片联合六仙饮治疗2型糖尿病(T2DM)的有效性和安全性,通过治疗前后对比,观察糖尿康片联合六仙饮治疗T2DM的临床疗效,并对其相关指标做出客观评价。为糖尿康片联合六仙饮治疗T2DM的推广作初步临床研究,为中医药在T2DM治疗中的运用提供一种安全有效的方法。方法:抽取河南中医药大学附属开封市中医院庞国明教授工作室及糖尿病区符合入选标准的2型糖尿病患者60例,治疗2个疗程(6个月)。在保证合理饮食和坚持适当运动的基础上,本课题采用自身对照研究的方法进行设计,进行糖尿康片联合六仙饮治疗前后的对比,比较治疗前后3个月、6个月症状积分变化,空腹血糖(FPG),餐后2小时血糖(2hPG),胰岛素抵抗指数(HOMA-IR),胰岛素敏感指数(HOMA-IS),C-肽,糖化血红蛋白(HbA1C)及血脂的改变,同时进行疗效评价。结果:(1)将符合标准的60例患者纳入组,其中男32例,占53.33%,女28例,占46.67%,平均年龄50.25±5.23岁,将两组性别、年龄等一般资料进行检验,差异均无显著性意义(P0.05),具有可比性。(2)治疗前后空腹血糖平均达标天数为100.23±65.85,餐后2小时血糖平均达标天数为98.03±69.58;(3)总有效率:治疗3月总有效率为83.3%,治疗6月总有效率为95%;(4)中医症状积分:治疗3月较治疗前下降,差异有统计学意义(P0.05);治疗6月较治疗前明显下降,差异有显著性统计学意义(P0.01);治疗3月与治疗6月组间比较,后者较前者下降更明显,差异有显著性统计学意义(P0.01)。(5)FPG:治疗3月较治疗前下降,差异有统计学意义(P0.05);治疗6月较治疗前明显下降,差异有显著性统计学意义(P0.01);治疗3月与治疗6月组间比较,后者较前者下降更明显,差异有显著性统计学意义(P0.01);2h PG:治疗3月、治疗6月较治疗前均明显下降,差异有显著性意义(P0.01);治疗3月与治疗6月组间比较,后者较前者下降更明显,差异有显著性统计学意义(P0.01)。(6)HbA1c:治疗3月较治疗前下降,差异有统计学意义(P0.05);治疗6月较治疗前明显下降,差异有显著性统计学意义(P0.01);治疗3月与治疗6月组间比较,后者较前者下降更明显,差异有显著性统计学意义(P0.01);(7)HOMA-IR、HOMA-IS:治疗3月较治疗前均改善,差异有统计学意义(P0.05),治疗6月较治疗前均明显改善,差异有显著性统计学意义(P0.01);HOMA-IR:治疗3月与治疗6月组间比较,后者较前者下降更明显,差异有显著性统计学意义(P0.01);HOMA-IS:治疗3月与治疗6月组间比较,后者较前者下降明显,差异有显著性统计学意义(P0.05)。(8)TC、LDL-C:在调节TC、LDL-C方面,治疗3个月后TC、LDL-C均可得到明显改善,比较有显著性差异(P0.01);在调节TG、HDL-C方面:治疗后3个月与治疗后6个月较治疗前均得到改善,其中治疗后6个月较治疗后3个月改善明显,比较有显著性差异(P0.01);(9)安全性分析:治疗组和对照组血、尿、粪常规,肝、肾功能,心电图指标变化无统计学意义(P0.05),在临床治疗过程中所有病人均未出现不良反应和过敏现象。结论:①有效性:治疗3个月总有效率为83.3%,治疗6个月总有效率为95%,证实糖尿康片联合六仙饮治疗2型糖尿病确实有一定疗效;②糖尿康片和六仙饮联合可明显降低患者FPG、2h PG、Hb A1C相关指标,调节脂代谢紊乱,并可有效改善其临床症状,初步判定其与增强胰岛素敏感性,降低胰高血糖素水平,改善胰岛素抵抗,促进胰岛素分泌等机理有关;③量效关系::在7≤FPG8mmol/L:糖尿康片5片日三次口服;8≤FPG11mmol/L糖尿康片8片日三次口服,11≤FPG≤15mmol/L糖尿康片10片日三次口服能较好降低空腹及餐后2小时血糖,初步判定其有一定的临床量效关系;④时效性:在6个月疗程内,随着时间延长疗效越确切;⑤安全性:在治疗过程中,未发现药物明显毒副作用,值得临床进一步深入研究及作进一步推广及应用。
[Abstract]:Objective: to systematically observe the efficacy and safety of diabetes combined with Liu Xian Yin in the treatment of type 2 diabetes (T2DM), and to observe the clinical efficacy of diabetes combined with Liu Xian Decoction in the treatment of T2DM through comparison before and after treatment, and to make an objective evaluation of its related indexes. A preliminary clinical study on the promotion of the combination of diabetes Kang Tablet and Liu Xian Yin in the treatment of T2DM is made. To provide a safe and effective method for the use of traditional Chinese medicine in the treatment of T2DM. Methods: to extract 60 cases of type 2 diabetic patients in the hospital of traditional Chinese medicine, Kaifeng University of Chinese medicine, Henan and the diabetes area, which conform to the standard of admission, and treat 2 courses of treatment (6 months). On the basis of ensuring reasonable diet and insisting on proper exercise, The subjects were designed with the method of self-control study, and compared before and after the treatment of the diabetes combined with six Xian Yin, compared with the 3 months, 6 months after the treatment, fasting blood glucose (FPG), 2 hours postprandial blood glucose (2hPG), insulin resistance index (HOMA-IR), insulin sensitivity index (HOMA-IS), C- peptide, glycosylated hemoglobin (HbA1C), The results were as follows: (1) 60 patients were included in the group, including 32 men, 53.33%, 28 women, 46.67%, and the average age of 50.25 + 5.23 years. There was no significant difference between the two groups of sex and age (P0.05). (2) the average level of fasting blood glucose before and after treatment was reached. The number of standard days was 100.23 + 65.85, the average number of blood glucose in 2 hours after meal was 98.03 + 69.58; (3) total effective rate: the total effective rate in March was 83.3%, the total effective rate in June was 95%; (4) the TCM symptom integral: the treatment March was lower than before the treatment (P0.05); the treatment June was significantly lower than before the treatment, the difference has significant statistics. Learning significance (P0.01); compared with the June treatment group in March and the treatment group, the latter was more obvious than the former, and the difference had significant statistical significance (P0.01). (5) the difference was statistically significant (P0.05) in March compared with before the treatment (P0.05); the treatment in June was significantly lower than before the treatment (P0.01); the treatment between March and June treatment group was between the two groups. Compared with the former, the latter was more obvious than the former, and the difference had significant statistical significance (P0.01); the treatment of 2H PG: in March, the treatment June was significantly lower than before the treatment, the difference was significant (P0.01); the treatment of March and the treatment June group was more obvious than the former, the difference was significant statistically significant (P0.01). (6) HbA1c: treatment in March compared with treatment. Before treatment, the difference was statistically significant (P0.05); the treatment was significantly decreased in June compared with that before treatment (P0.01); the treatment between March and June group was more obvious than the former, and the difference was significant (P0.01); (7) HOMA-IR, HOMA-IS: was improved in March compared with before treatment, and the difference was statistically significant Significance (P0.05), the treatment was significantly improved in June than before the treatment, the difference was significant statistical significance (P0.01); HOMA-IR: treatment in March and the treatment of June group, the latter was more obvious than the former, the difference was significant statistical significance (P0.01); HOMA-IS: treatment in March and June group compared, the latter was significantly lower than the former, the difference was significant. Statistical significance (P0.05) (8) (8) TC, LDL-C: in the regulation of TC, LDL-C, 3 months after treatment, TC, LDL-C can be significantly improved, there is a significant difference (P0.01); in the regulation of TG, HDL-C: 3 months after treatment and 6 months after treatment were better than before the treatment, 6 months after treatment improved significantly compared with the 3 months after the treatment, more significant. Difference (P0.01); (9) safety analysis: there was no significant difference in blood, urine, fecal routine, liver, kidney function and electrocardiogram in the treatment group and the control group (P0.05). No adverse reactions and allergies were found in all patients during the clinical treatment. Conclusion: (1) the effectiveness: the total effective rate of treatment for 3 months was 83.3%, and the total effective rate was 95% for the treatment of 6 months. Solid diabetes combined with Liu Xian decoction has certain effect in the treatment of type 2 diabetes, and the combination of diabetic and six Xian Yin can obviously reduce the related indexes of FPG, 2h PG, Hb A1C, regulate the disorder of lipid metabolism, and can effectively improve the clinical symptoms, and preliminarily determine its sensitivity to the enhancement of insulin, the lowering of the glucagon level and the improvement of insulin. Anti -, promote insulin secretion and other mechanisms; (3) the dose effect relationship: three oral administration of 5 tablets on 7 < FPG8mmol/L: diabetic tablets; three oral administration of 8 tablets on 8 tablets of 8 < < < < < < < 15mmol/L >; 11 < < FPG < < 15mmol/L diabetes mellitus, three oral administration can lower the fasting and 2 hours postprandial blood glucose, and preliminarily determine that there is a certain clinical effect relationship. Timeliness: within 6 months of treatment, the more accurate the effect is prolonged with time; 5. Safety: in the course of treatment, no obvious toxic and side effects have been found. It is worth further in-depth study and further application.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R255.4
本文编号：2140843
[Abstract]:Objective: to systematically observe the efficacy and safety of diabetes combined with Liu Xian Yin in the treatment of type 2 diabetes (T2DM), and to observe the clinical efficacy of diabetes combined with Liu Xian Decoction in the treatment of T2DM through comparison before and after treatment, and to make an objective evaluation of its related indexes. A preliminary clinical study on the promotion of the combination of diabetes Kang Tablet and Liu Xian Yin in the treatment of T2DM is made. To provide a safe and effective method for the use of traditional Chinese medicine in the treatment of T2DM. Methods: to extract 60 cases of type 2 diabetic patients in the hospital of traditional Chinese medicine, Kaifeng University of Chinese medicine, Henan and the diabetes area, which conform to the standard of admission, and treat 2 courses of treatment (6 months). On the basis of ensuring reasonable diet and insisting on proper exercise, The subjects were designed with the method of self-control study, and compared before and after the treatment of the diabetes combined with six Xian Yin, compared with the 3 months, 6 months after the treatment, fasting blood glucose (FPG), 2 hours postprandial blood glucose (2hPG), insulin resistance index (HOMA-IR), insulin sensitivity index (HOMA-IS), C- peptide, glycosylated hemoglobin (HbA1C), The results were as follows: (1) 60 patients were included in the group, including 32 men, 53.33%, 28 women, 46.67%, and the average age of 50.25 + 5.23 years. There was no significant difference between the two groups of sex and age (P0.05). (2) the average level of fasting blood glucose before and after treatment was reached. The number of standard days was 100.23 + 65.85, the average number of blood glucose in 2 hours after meal was 98.03 + 69.58; (3) total effective rate: the total effective rate in March was 83.3%, the total effective rate in June was 95%; (4) the TCM symptom integral: the treatment March was lower than before the treatment (P0.05); the treatment June was significantly lower than before the treatment, the difference has significant statistics. Learning significance (P0.01); compared with the June treatment group in March and the treatment group, the latter was more obvious than the former, and the difference had significant statistical significance (P0.01). (5) the difference was statistically significant (P0.05) in March compared with before the treatment (P0.05); the treatment in June was significantly lower than before the treatment (P0.01); the treatment between March and June treatment group was between the two groups. Compared with the former, the latter was more obvious than the former, and the difference had significant statistical significance (P0.01); the treatment of 2H PG: in March, the treatment June was significantly lower than before the treatment, the difference was significant (P0.01); the treatment of March and the treatment June group was more obvious than the former, the difference was significant statistically significant (P0.01). (6) HbA1c: treatment in March compared with treatment. Before treatment, the difference was statistically significant (P0.05); the treatment was significantly decreased in June compared with that before treatment (P0.01); the treatment between March and June group was more obvious than the former, and the difference was significant (P0.01); (7) HOMA-IR, HOMA-IS: was improved in March compared with before treatment, and the difference was statistically significant Significance (P0.05), the treatment was significantly improved in June than before the treatment, the difference was significant statistical significance (P0.01); HOMA-IR: treatment in March and the treatment of June group, the latter was more obvious than the former, the difference was significant statistical significance (P0.01); HOMA-IS: treatment in March and June group compared, the latter was significantly lower than the former, the difference was significant. Statistical significance (P0.05) (8) (8) TC, LDL-C: in the regulation of TC, LDL-C, 3 months after treatment, TC, LDL-C can be significantly improved, there is a significant difference (P0.01); in the regulation of TG, HDL-C: 3 months after treatment and 6 months after treatment were better than before the treatment, 6 months after treatment improved significantly compared with the 3 months after the treatment, more significant. Difference (P0.01); (9) safety analysis: there was no significant difference in blood, urine, fecal routine, liver, kidney function and electrocardiogram in the treatment group and the control group (P0.05). No adverse reactions and allergies were found in all patients during the clinical treatment. Conclusion: (1) the effectiveness: the total effective rate of treatment for 3 months was 83.3%, and the total effective rate was 95% for the treatment of 6 months. Solid diabetes combined with Liu Xian decoction has certain effect in the treatment of type 2 diabetes, and the combination of diabetic and six Xian Yin can obviously reduce the related indexes of FPG, 2h PG, Hb A1C, regulate the disorder of lipid metabolism, and can effectively improve the clinical symptoms, and preliminarily determine its sensitivity to the enhancement of insulin, the lowering of the glucagon level and the improvement of insulin. Anti -, promote insulin secretion and other mechanisms; (3) the dose effect relationship: three oral administration of 5 tablets on 7 < FPG8mmol/L: diabetic tablets; three oral administration of 8 tablets on 8 tablets of 8 < < < < < < < 15mmol/L >; 11 < < FPG < < 15mmol/L diabetes mellitus, three oral administration can lower the fasting and 2 hours postprandial blood glucose, and preliminarily determine that there is a certain clinical effect relationship. Timeliness: within 6 months of treatment, the more accurate the effect is prolonged with time; 5. Safety: in the course of treatment, no obvious toxic and side effects have been found. It is worth further in-depth study and further application.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R255.4
【相似文献】
相关期刊论文 前10条
1 李权超,何英强,陈星伟;194名新兵的个性特征及其与焦虑和抑郁关系的研究[J];中国全科医学;2004年07期
2 谭志刚,王丰,何雁,尹理辉,张立;大学生在传染性非典型肺炎流行前后健身情况变化的调查[J];南华大学学报(医学版);2004年01期
3 朱树宽;;增效活化散治疗2型糖尿病临床研究[J];新中医;2009年09期
4 殷平;;6min步行试验的测试稳定性研究[J];中国医药指南;2013年06期
5 苗发启;;消脂复肝汤治疗非酒精性脂肪性肝病的临床研究[J];新中医;2010年10期
6 吴国庆;吴其恺;江远;;肝络欣丸为主治疗慢性乙型病毒性肝炎63例疗效观察[J];新中医;2006年05期
7 黄国平,张亚林,王芙蓉;传染性非典型肺炎期间大学生的求助方式(英文)[J];中国临床康复;2004年27期
8 宋丽;;自拟方Ⅲ号治疗慢性溃疡性结肠炎[J];辽宁中医药大学学报;2009年12期
9 张建扬,吴桃林;连云港市大学生心理健康状况调查[J];中国校医;2002年01期
10 刘明华;;中药治疗中心性浆液性脉络膜视网膜病变疗效观察[J];国际医药卫生导报;2006年19期
相关重要报纸文章 前1条
1 复旦大学公共卫生学院 同济大学基础医学部;大连珍奥产品对机体健康影响的研究课题总结[N];中国老年报;2003年
相关硕士学位论文 前3条
1 孔丽丽;糖尿康片联合六仙饮治疗消渴病（2型糖尿病）气阴两虚证的临床研究[D];河南中医药大学;2016年
2 邹清芳;补血Ⅰ号方治疗化疗后血小板减少的临床研究[D];成都中医药大学;2013年
3 刘华辉;平衡针治疗急性腹痛的临床研究[D];广州中医药大学;2011年
，本文编号：2140843
本文链接：https://www.wllwen.com/zhongyixuelunwen/2140843.html
最近更新
教材专著
