加味四物颗粒治疗痰浊中阻型高血压病及改善其尿微量白蛋白的研究

发布时间：2018-07-24 12:38

【摘要】：目的：本课题是以顾国龙教授所创制的加味四物颗粒为基础,观察对高血压痰浊中阻证患者的临床疗效及尿微量白蛋白的排泄量的影响,从而探究其肾损害早期保护的可能的作用机制。方法：选取南京中医药大学附属江阴市中医院符合西医诊断标准、痰浊中阻证的原发性高血压病患者共58例,随机分成治疗组29例,对照组29例,两组在年龄、性别、病程、病情等临床一般性资料方面无显著性差异。治疗组：加味四物颗粒bid冲服,加坎地沙坦片8mg qd口服。对照组：坎地沙坦片8mg qd口服。疗程均为8周,然后观察两组治疗前后的降压效果、尿微量白蛋白、中医征候疗效及肝肾功能、血尿粪等安全性指标。结果：(1)降压疗效：治疗组总有效率为86.20%,对照组总有效率为62.07%,治疗组优于对照组,经统计学分析,有明显统计学差异(P0.05)。(2)中医证候疗效：治疗组总有效率为86.21%,对照组总有效率为55.17%,治疗组优于对照组,经统计学分析,有明显统计学差异(P0.05)。(3)尿微量白蛋白排泄量：治疗后治疗组的尿微量白蛋白排泄量明显低于对照组,经统计学分析,有明显统计学差异(P0.05)。(4)不良反应：1例对照组病例产生面部潮红的症状,没有发现其他不良反应。结论：加味四物颗粒联合使用坎地沙坦治疗高血压痰浊中阻证,不仅能降压、改善临床症状,还能有效降低尿微量白蛋白,提示对高血压早期肾损害有一定的保护作用。
[Abstract]:Objective: on the basis of the Jiawei Siwu granule, created by Professor Gu Guolong, we observe the effect of the clinical curative effect and the excretion of urine microalbuminuria in the patients with hypertension and phlegm turbidity, so as to explore the possible mechanism of the early protection of the renal damage. Method: select the affiliated Jiangyin hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine. A total of 58 patients with primary hypertension were randomly divided into 29 cases in the treatment group and 29 in the control group. The two groups had no significant difference in age, sex, course of disease, and the condition of the disease. The treatment group was treated with Jiawei Siwu granule bid and candesartan 8mg QD. The treatment course of 8mg QD was 8 weeks. Then the effect of blood pressure, microalbuminuria, liver and kidney function, hematuria and feces were observed before and after treatment in the two groups. Results: (1) the curative effect of the treatment group was 86.20%, the total effective rate of the control group was 62.07%, and the treatment group was better than the control group. Statistically analyzed, statistically analyzed, there were Significant difference (P0.05). (2) the curative effect of TCM syndrome: the total effective rate of the treatment group was 86.21%, the total effective rate of the control group was 55.17%, the treatment group was superior to the control group. The statistical analysis showed significant difference (P0.05). (3) the urine microalbumin excretion of the treatment group was significantly lower than that of the control group after treatment, and the amount of urine albumin excretion was significantly lower than that of the control group. Statistical analysis, there were significant statistical differences (P0.05). (4) adverse reactions: 1 cases of control group had facial flush symptoms and no other adverse reactions were found. Conclusion: the combination of candesartan and candesartan in the treatment of hypertension and phlegm turbidity can not only reduce blood pressure, improve clinical symptoms, but also effectively reduce urine microalbuminuria. It suggested that there was a certain protective effect on renal damage in early stage of hypertension.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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