化瘀涤痰汤治疗痛风性关节炎慢性期（痰瘀痹阻型）的临床研究

发布时间：2018-07-25 15:42

【摘要】：目的:通过对化瘀涤痰汤治疗痛风性关节炎慢性期(痰瘀痹阻型)的临床研究,从而观察并评价其临床疗效及安全性,为临床治疗痛风性关节炎提供更有效的中药新药。方法:通过对痛风性关节炎慢性期(痰瘀痹阻型)的准确中西医诊断,需严格筛选出符合西医痛风性关节炎慢性期且中医辩证属痰瘀痹阻型诊断标准的病例方可纳入实验。将符合纳入标准的60例患者随机分成2组:治疗组、对照组,两组均为30例。治疗组给予中药化瘀涤痰汤口服,对照组给予西药别嘌醇口服,疗程为1个月。观察治疗前后血尿酸水平、症状积分、安全性等指标的变化。将所得数据应用统计学方法计算得出结论。科学评价化瘀涤痰汤治疗痛风性关节炎慢性期(痰瘀痹阻型)的临床疗效及安全性。结果:总有效率方面治疗组为93.33%,对照组为83.33%,治疗组总体疗效强于对照组(p0.05);治疗前两组患者血尿酸水平、症状积分无明显差异(P0.05),治疗前后两组患者组内比较血尿酸水平、症状积分均有下降,治疗后组间比较,差异有统计学意义(P0.05),说明治疗组对血尿酸水平、症状积分的改善情况要优于对照组;治疗组和对照组治疗前和治疗后单一症状积分比较:两组治疗前后组内比较单一症状积分均有下降,治疗后组间比较差异具有统计学意义(P0.05),治疗组对单一症状改善更明显。治疗组与对照组在治疗后安全性方面比较,有显著性差异(P0.05),治疗组在安全性方面要优于对照组。结论:化瘀涤痰汤对治疗痛风性关节炎具有较好的临床疗效,较服用别嘌醇在各方面的症状改善都存在优势,且临床应用中未见明显不良反应及副作用。也充分体现了中医辨证用药的优势,此方药值得在临床上广泛推广应用。
[Abstract]:Objective: to observe and evaluate the clinical efficacy and safety of Huayu Ditan decoction (Huayu Ditan decoction) in treating chronic stage of gouty arthritis (phlegm stasis obstruction type), and to provide a more effective new Chinese medicine for the treatment of gouty arthritis. Methods: through the accurate diagnosis of chronic stage of gouty arthritis (phlegm and stasis obstruction type), it is necessary to screen out the cases that accord with the diagnostic criteria of phlegm and stasis obstruction type in traditional Chinese medicine. 60 patients who met the inclusion criteria were randomly divided into two groups: treatment group, control group, 30 cases in both groups. The treatment group was treated with traditional Chinese medicine Huayu Ditan decoction and the control group with allopurinol for one month. The changes of serum uric acid level, symptom score and safety were observed before and after treatment. The data are calculated by statistical method. To evaluate the clinical efficacy and safety of Huayu Ditan decoction (Huayu Ditan decoction) in treating chronic stage of gouty arthritis. Results: the total effective rate was 93.33 in the treatment group and 83.33 in the control group. The overall curative effect in the treatment group was stronger than that in the control group (p0.05), and there was no significant difference in serum uric acid level and symptom score between the two groups before and after treatment (P0.05). After treatment, the difference was statistically significant (P0.05), which indicated that the improvement of the treatment group on serum uric acid level and symptom score was better than that of the control group. Treatment group and control group before and after treatment of single symptom score comparison: the two groups before and after treatment compared with the single symptom score decreased, the difference between the treatment group was statistically significant (P0.05), the treatment group on the single symptoms more obvious improvement. There was significant difference between the treatment group and the control group in the safety after treatment (P0.05), the treatment group was better than the control group in terms of safety. Conclusion: Huayu Ditan decoction has good clinical effect on treating gouty arthritis, and has advantages over allopurinol in improving symptoms, and there is no obvious adverse reaction and side effect in clinical application. It also fully reflects the advantages of traditional Chinese medicine based on syndrome differentiation, which is worth popularizing in clinic.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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