虚秘合剂治疗功能性便秘（气血亏虚型）的临床观察
发布时间：2018-07-27 11:08
【摘要】：研究目的：观察虚秘合剂对功能性便秘(气血亏虚型)的临床疗效及安全性,并初步探讨其作用机理,为治疗该病提供新的思路及方法。研究方法：收集绵阳市中医院2014年4月～2015年2月在消化内科专家门诊就诊的患者,符合纳入标准的40例,随机分为治疗组和对照组,两组各20例。其中治疗组给予虚秘合剂,对照组给予聚乙二醇4000散,疗程均为4周,观察治疗前后证候变化情况,比较两组治疗前后的疗效及安全性等。研究结果：1、经过4周治疗后,治疗组总有效率85.0%,对照组总有效率为60.0%,两组间有效率比较具有统计学意义(P0.05),治疗组疗效优于对照组。治疗组、对照组治疗前后积分均存在差异(P0.05),治疗组症状的改善优于对照组。2、在排便困难、排便时间、粪便性状、排便间隔、腹痛腹胀等症状积分的比较上,差异无统计学意义(P0.05),两组在改善上述症状方面疗效相似。而对神疲懒言、少食纳呆、体倦乏力、下坠不尽胀感的症状进行比较,差异具有统计学意义(P0.05),结合两组症状有效率的比较,可以得出治疗组和对照组对于症状改善均有效,而在次症的改善方面,治疗组疗效优于对照组。3、治疗组在服药期间患者均未出现明显不适症状及毒副作用,对照组2例患者服药期间出现一过性轻微腹痛、腹泻,不影响继续服药。两组病例在接受治疗期间监测相关安全指标均未见明显异常变化。4、在经过4周的治疗后,对治疗有效的患者进行1个月的随访,治疗组复发3例,对照组复发7例,两组复发率分别为17.6%、58.3%。两组复发率存在差异,有统计学意义(P0.05)。结论：虚秘合剂治疗功能性便秘(气血亏虚型)疗效可靠,未见明显不良反应,复发率低,值得进一步研究和临床推广。
[Abstract]:Objective: to observe the clinical efficacy and safety of deficiency decoction on functional constipation (deficiency of qi and blood), and to explore its mechanism, and to provide new ideas and methods for the treatment of this disease. Methods: 40 patients in Mianyang traditional Chinese Medicine Hospital from April 2014 to February 2015 were randomly divided into treatment group and control group with 20 cases in each group. The treatment group was treated with deficiency constipation mixture, the control group was given polyethylene glycol 4000 powder for 4 weeks, the changes of syndrome were observed before and after treatment, and the efficacy and safety of the two groups were compared before and after treatment. Results: after 4 weeks of treatment, the total effective rate of the treatment group was 85.0, the total effective rate of the control group was 60.00.The effective rate of the two groups was statistically significant (P0.05). The curative effect of the treatment group was better than that of the control group. The scores of treatment group and control group were significantly different before and after treatment (P0.05). The improvement of symptoms in treatment group was better than that in control group. The scores of defecation difficulty, defecation time, fecal character, defecation interval, abdominal pain and abdominal distension were compared. The difference was not statistically significant (P0.05), the two groups in the improvement of the symptoms of similar efficacy. On the other hand, the symptoms of fatigue, less food intake, fatigue and undistension were compared, and the difference was statistically significant (P0.05). In combination with the comparison of the effective rate of symptoms between the two groups, it can be concluded that the treatment group and the control group are effective for the improvement of symptoms. In the improvement of the secondary symptoms, the curative effect of the treatment group was better than that of the control group. The patients in the treatment group had no obvious symptoms of discomfort and side effects during the period of taking medicine, while the two patients in the control group had transient mild abdominal pain and diarrhea during the treatment period. Does not affect the continuation of medication. After 4 weeks of treatment, the patients with effective treatment were followed up for one month. There were 3 cases of recurrence in the treatment group and 7 cases in the control group, and there were 3 cases of recurrence in the treatment group and 7 cases in the control group after 4 weeks of treatment, and there were 3 cases of recurrence in the treatment group and 7 cases in the control group. The recurrence rate of the two groups was 17.6 and 58.3 respectively. There was significant difference in recurrence rate between the two groups (P0.05). Conclusion: the treatment of functional constipation (deficiency of qi and blood deficiency type) with deficiency of constipation is reliable, no obvious adverse reactions and low recurrence rate, which is worthy of further study and clinical popularization.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35
本文编号：2147628
[Abstract]:Objective: to observe the clinical efficacy and safety of deficiency decoction on functional constipation (deficiency of qi and blood), and to explore its mechanism, and to provide new ideas and methods for the treatment of this disease. Methods: 40 patients in Mianyang traditional Chinese Medicine Hospital from April 2014 to February 2015 were randomly divided into treatment group and control group with 20 cases in each group. The treatment group was treated with deficiency constipation mixture, the control group was given polyethylene glycol 4000 powder for 4 weeks, the changes of syndrome were observed before and after treatment, and the efficacy and safety of the two groups were compared before and after treatment. Results: after 4 weeks of treatment, the total effective rate of the treatment group was 85.0, the total effective rate of the control group was 60.00.The effective rate of the two groups was statistically significant (P0.05). The curative effect of the treatment group was better than that of the control group. The scores of treatment group and control group were significantly different before and after treatment (P0.05). The improvement of symptoms in treatment group was better than that in control group. The scores of defecation difficulty, defecation time, fecal character, defecation interval, abdominal pain and abdominal distension were compared. The difference was not statistically significant (P0.05), the two groups in the improvement of the symptoms of similar efficacy. On the other hand, the symptoms of fatigue, less food intake, fatigue and undistension were compared, and the difference was statistically significant (P0.05). In combination with the comparison of the effective rate of symptoms between the two groups, it can be concluded that the treatment group and the control group are effective for the improvement of symptoms. In the improvement of the secondary symptoms, the curative effect of the treatment group was better than that of the control group. The patients in the treatment group had no obvious symptoms of discomfort and side effects during the period of taking medicine, while the two patients in the control group had transient mild abdominal pain and diarrhea during the treatment period. Does not affect the continuation of medication. After 4 weeks of treatment, the patients with effective treatment were followed up for one month. There were 3 cases of recurrence in the treatment group and 7 cases in the control group, and there were 3 cases of recurrence in the treatment group and 7 cases in the control group after 4 weeks of treatment, and there were 3 cases of recurrence in the treatment group and 7 cases in the control group. The recurrence rate of the two groups was 17.6 and 58.3 respectively. There was significant difference in recurrence rate between the two groups (P0.05). Conclusion: the treatment of functional constipation (deficiency of qi and blood deficiency type) with deficiency of constipation is reliable, no obvious adverse reactions and low recurrence rate, which is worthy of further study and clinical popularization.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35
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