复方芪麻胶囊干预治疗对H型高血压患者同型半胱氨酸、瘦素水平的影响
发布时间：2018-07-29 14:54
【摘要】：目的观察复方芪麻胶囊干预治疗对H型高血压气虚痰浊证患者的血压、同型半胱氨酸(Hcy)、瘦素的影响。方法将96例H型高血压气虚痰浊证患者按照随机数字表法分为治疗组和对照组各48例,两组均给予基础降压药依那普利叶酸片(10 mg/0.8 mg,1次/日)治疗,其中治疗组加用复方芪麻胶囊(2粒/次,3次/日),疗程为8周,分别比较两组患者治疗前后的收缩压、舒张压、Hcy及瘦素的水平。并采用线性回归法探讨治疗前所有患者收缩压、舒张压分别与Hcy、瘦素之间的相关性。结果治疗后,与对照组比较,治疗组收缩压及瘦素显著下降,差异具有统计学意义(P0.05),而治疗后两组Hcy及舒张压进行组间比较,差异无统计学意义(P0.05)。相关性研究中,Hcy、瘦素分别与收缩压呈正相关(P0.01),而Hcy、瘦素与舒张压无明显相关性(P0.05)。结论复方芪麻胶囊干预治疗H型高血压能够明显改善患者收缩压、降低瘦素水平,Hcy、瘦素有可能作为评价H型高血压严重程度的指标。
[Abstract]:Objective to observe the effect of compound Qima capsule intervention on blood pressure and homocysteine (Hcy), leptin in patients with H type hypertension syndrome of qi deficiency and phlegm turbidity. Methods 96 patients with H type hypertensive qi deficiency and phlegm turbid syndrome were randomly divided into treatment group (n = 48) and control group (n = 48). Both groups were treated with basic antihypertensive drug enalapril folic acid tablet (10 mg/0.8 mg / d). The treatment group was treated with compound Qi-ma capsule (2 capsules / 3 times a day) for 8 weeks. The systolic blood pressure, diastolic blood pressure, Hcy and leptin levels were compared between the two groups before and after treatment. The relationship between systolic blood pressure, diastolic blood pressure and Hcyand leptin in all patients before treatment was investigated by linear regression method. Results compared with the control group, the systolic blood pressure and leptin in the treatment group decreased significantly (P0.05), but there was no significant difference in Hcy and diastolic blood pressure between the two groups after treatment (P0.05). There was a positive correlation between Hcyand leptin and systolic blood pressure (P0.01), while there was no significant correlation between Hcyand leptin and diastolic blood pressure (P0.05). Conclusion the intervention of compound Qima capsule in the treatment of H type hypertension can obviously improve the systolic blood pressure and decrease the level of leptin. Leptin may be used as an index to evaluate the severity of H type hypertension.
【作者单位】： 广东省第二中医院心血管科;
【基金】：广东省中医药局建设中医药强省科研项目(No.20141023)
【分类号】：R259
本文编号：2153035
[Abstract]:Objective to observe the effect of compound Qima capsule intervention on blood pressure and homocysteine (Hcy), leptin in patients with H type hypertension syndrome of qi deficiency and phlegm turbidity. Methods 96 patients with H type hypertensive qi deficiency and phlegm turbid syndrome were randomly divided into treatment group (n = 48) and control group (n = 48). Both groups were treated with basic antihypertensive drug enalapril folic acid tablet (10 mg/0.8 mg / d). The treatment group was treated with compound Qi-ma capsule (2 capsules / 3 times a day) for 8 weeks. The systolic blood pressure, diastolic blood pressure, Hcy and leptin levels were compared between the two groups before and after treatment. The relationship between systolic blood pressure, diastolic blood pressure and Hcyand leptin in all patients before treatment was investigated by linear regression method. Results compared with the control group, the systolic blood pressure and leptin in the treatment group decreased significantly (P0.05), but there was no significant difference in Hcy and diastolic blood pressure between the two groups after treatment (P0.05). There was a positive correlation between Hcyand leptin and systolic blood pressure (P0.01), while there was no significant correlation between Hcyand leptin and diastolic blood pressure (P0.05). Conclusion the intervention of compound Qima capsule in the treatment of H type hypertension can obviously improve the systolic blood pressure and decrease the level of leptin. Leptin may be used as an index to evaluate the severity of H type hypertension.
【作者单位】： 广东省第二中医院心血管科;
【基金】：广东省中医药局建设中医药强省科研项目(No.20141023)
【分类号】：R259
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