柴胡类方对于治疗功能性消化不良伴焦虑状态的疗效分析

发布时间：2018-07-30 07:48

【摘要】：背景:功能性胃肠病是临床常见的慢性功能性疾病,其中的功能性消化不良具有较高发病率,是临床常见病、多发病。随着社会进步和生活水平的提高,本病发病率具有明显升高趋势,且其发病与精神心理因素密切相关,因此治疗效果欠佳,反复发作,迁延难愈。临床治疗过程中给予对症处理有时很难达到预期效果,而同时给予精神心理方面的干预治疗,可能会有明显效果。中医药在本病治疗过程中有明显优势,中医药对情志的调节历史悠久,疗效显著,应当在本病治疗中充分发挥优势,总结处方用药规律,提高临床疗效。目的:通过对功能性消化不良伴焦虑状态的病因病机及症状的研究和总结,对病例进行对照实验设计,并进行数据研究分析,验证柴胡类方对功能性消化不良伴焦虑状态的疗效,总结临床有效治疗方法。方法:临床收集符合标准的功能性消化不良伴有焦虑状态的患者65例,根据临床调查表,调查记录患者的临床症状积分及严重程度,对所选患者进行随机分组,分为对照组和实验组;对照组给予常见西药对症处理,无情绪方面的治疗,实验组在对照组基础上再给予柴胡类方进行情绪的调节及临床症状的控制;记录实验前后及治疗组与实验组之间的区别,通过对实验数据及实验结果进行统计分析,得出相关结论。相关数据采用SPSS17.0统计软件处理分析。结果:在本研究中,经柴胡类方治疗后,经检验,单项证候积分如大便不畅、身重困倦、小便短黄、大便稀溏等较治疗前无显著性差异(P0.05),而对于胃脘疼痛、胀满、嗳气反酸、饮食减少等症状的改善治疗组与对照组之间有差异性,说明柴胡类方对于改善胃脘胀满疼痛、嗳气反酸等代表性症状有良好效果;对于睡眠的影响,经检验P0.05,治疗前后对于改善睡眠情况差异具有统计学意义;对于症状积分的改善,中医症状积分和SAS焦虑积分均显示实验组治疗前后的差异性有统计学意义;最终本实验结果显示,实验组经柴胡类方加减治疗后,临床症状明显减轻,其有效率达到93.33%,经检验有统计学意义。结论:柴胡类方对于改善中医临床症状及焦虑状态有良好疗效,相比单纯西药对症治疗有明显优势,其中既包括症状的减轻又包括情绪的调控。
[Abstract]:Background: functional gastrointestinal disease is a common chronic functional disease in clinic, and functional dyspepsia has a high incidence. With the progress of society and the improvement of living standard, the incidence of this disease is obviously increasing, and its incidence is closely related to mental and psychological factors, so the therapeutic effect is not good, repeated attacks are difficult to cure. In the course of clinical treatment, it is difficult to achieve the desired effect by giving symptomatic treatment, but at the same time, the psycho-psychological intervention may have obvious effect. Chinese medicine has obvious advantages in the course of treatment of this disease. Chinese medicine has a long history of regulating emotion and remarkable curative effect. We should give full play to the advantages in the treatment of this disease, sum up the law of prescribing drugs, and improve the clinical curative effect. Objective: to study and summarize the etiology, pathogenesis and symptoms of functional dyspepsia with anxiety. To verify the efficacy of Bupleurum decoction in the treatment of functional dyspepsia with anxiety, summarize the effective clinical treatment methods. Methods: 65 patients with functional dyspepsia accompanied with anxiety were collected. According to the clinical questionnaire, the clinical symptom score and severity of the patients were recorded, and the selected patients were randomly divided into two groups. The control group was divided into control group and experimental group, the control group was treated with common western medicine without emotional treatment, and the experimental group was treated with Bupleurum recipe on the basis of control group for emotional regulation and clinical symptom control. The differences between the experimental group and the experimental group before and after the experiment were recorded and the relevant conclusions were obtained by statistical analysis of the experimental data and the experimental results. The related data were analyzed by SPSS17.0 statistical software. Results: in this study, after treatment with Bupleurum recipe, after examination, the single syndrome score, such as stool unobstructed, heavy sleepiness, short yellow urine, loose stool and so on, had no significant difference (P0.05), but for epigastric pain, fullness, belching regurgitation, and so on, there was no significant difference between before treatment and so on (P0.05), but for stomachache, bloating, belching and regurgitating acid, and so on, There were differences between the treatment group and the control group in improving the symptoms such as diet reduction, which indicated that Chaihu recipe had a good effect on improving the typical symptoms such as stomachache, belching and regurgitation, and the effect on sleep. After testing P0.05, before and after treatment for the improvement of sleep has statistical significance, for the improvement of symptom score, TCM symptom score and SAS anxiety score show the difference between the experimental group before and after treatment has statistical significance. Finally, the experimental group was treated with Bupleurum decoction, the clinical symptoms were obviously alleviated, and the effective rate reached 93.33, which was statistically significant. Conclusion: Bupleurum prescription has a good effect on improving the clinical symptoms and anxiety state of traditional Chinese medicine, which has obvious advantages over western medicine alone in the treatment of symptoms, including both symptom relief and emotional regulation.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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