刘伟胜教授治疗肺癌用药规律的挖掘分析

发布时间：2018-08-02 17:49

【摘要】：目的:基于中医传承辅助系统(V2.5)探讨刘伟胜教授治疗肺癌的中医用药经验及组方规律。方法:收集刘伟胜教授在广东省中医院2016年2月至2017年2月门诊接诊的肺癌病例为研究对象,提取处方,建立数据库,采用该软件集成的规则分析、改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法,挖掘分析用药经验。结果:纳入患者290例,并录入处方290个,使用中药共148味。确定处方中药物的使用频次和药物之间的关联规则,其中使用频次高于65的中药共24味,使用频次最高的前5味药依次为半枝莲(267),白花蛇舌草(265),全蝎(238),桃仁(228),淫羊藿(221),5味药所对应的常用剂量分别为20,20,10,10,15 g;支持度为185,置信度为0.95时,共有药物组合32组,使用频次最高的前5位药物组合依次为白花蛇舌草-半枝莲(259),全蝎-半枝莲(226),白花蛇舌草-全蝎(223),白花蛇舌草-全蝎-半枝莲(220),桃仁-半枝莲(218);设置相关度为9,惩罚度为2,演化出22个药物核心组合及11首新方。结论:刘伟胜教授临证以"攻毒扶正"为根本,强调癌毒是肺癌发生的直接因素,而正气不足是肺癌发病的关键,临证主张清热毒、破瘀毒、化痰毒并注重顾护脾肾之气,尤以温补肾阳为主。
[Abstract]:Objective: to explore the experience and prescription of Professor Liu Weisheng in the treatment of lung cancer based on traditional Chinese Medicine inheritance Assistance system (V2.5). Methods: lung cancer cases received by Professor Liu Weisheng from February 2016 to February 2017 in Guangdong traditional Chinese Medicine Hospital were collected as research objects, prescriptions were extracted, database was established, rule analysis of software integration was used to improve mutual information method. Data mining methods such as entropy clustering and unsupervised entropy hierarchical clustering in complex systems are used to analyze drug use experience. Results: 290 patients were included, 290 prescriptions were inputted and 148 herbs were used. To determine the association rules between the frequency of drug use and the drug use in a prescription, of which 24 herbs were used more frequently than 65. The most frequently used drugs were Scutellaria Scutellariae (267), Scutellaria albicans (265), Scorpion (238), Peach seed (228), Epimedium (221) and Herba Epimedii (221). The top five drug combinations with the highest frequency were Scutellaria Scutellariae (259), Scutellaria Scutellariae (226), Scutellaria Scutellariae (223), Scutellaria Scutellariae (220), Peach Kernel and Scutellaria Scutellaria (218). The penalty degree was 2, and 22 drug core combinations and 11 new prescriptions were developed. Conclusion: professor Liu Weisheng's clinical syndrome is based on "attacking the poison and strengthening the centrality", and emphasizes that cancer poison is the direct factor of lung cancer, and the deficiency of proper qi is the key to the development of lung cancer. The clinical syndrome advocates clearing heat, breaking blood stasis toxin, resolving phlegm poison and paying attention to protecting spleen and kidney qi. Especially to warm up the kidney yang.
【作者单位】：广州中医药大学第二临床医学院;广东省中医院;
【基金】：广东省大学生创新创业训练计划项目(201610572060)
【分类号】：R249;R273

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