三七止痛方治疗稳定性心绞痛痰瘀阻络证的临床研究

发布时间：2018-08-03 18:24

【摘要】：目的:评价三七止痛方治疗稳定性心绞痛痰瘀阻络证的临床疗效,并初步探讨三七止痛方的作用机理。方法:将符合纳入标准的60例患者随机分为治疗组和对照组各30例,在两组均给予常规西医治疗的基础上,试验组加服三七止痛方治疗,对照组不进行中医治疗,6周为一疗程,观察记录两组试验前后的心绞痛疗效、心电图有效率、硝酸甘油服用量变化、西雅图心绞痛评分变化、中医证候变化指标等,采用SPSS 17.0程序进行数据统计,继而得出结论。结果:治疗后两组心绞痛、心电图、硝酸甘油服用量、中医证候综合指标及证候总积分、西雅图量表评分均较治疗前改善,且治疗组优于对照组,具有统计学意义(P0.01或P0.05)。治疗组中医单项症状积分均较前减低,具有显著的统计学差异(P0.01),对照组单项积分(除外不寐、舌苔)减少均有统计学意义(P0.01或P0.05),且治疗后治疗组单项积分(除气短与不寐)低于对照组,有统计学意义(P0.05)。实验期间未记录到安全指标及不良反应等异常。结论:三七止痛方联合西医治疗方案能显著改善稳定性心绞痛痰瘀阻络证患者的临床症状,且优于单纯西医治疗的效果,临床应用安全可靠。
[Abstract]:Objective: to evaluate the clinical effect of Sanqi Zhitong recipe in treating stable angina pectoris with phlegm and stagnation of collaterals, and to explore the mechanism of Sanqi Zhitong recipe. Methods: 60 patients who met the inclusion criteria were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). On the basis of routine western medicine treatment, the experimental group was treated with Sanqi Zhitong recipe, and the control group was treated without TCM treatment for 6 weeks. The effect of angina pectoris, the effective rate of electrocardiogram, the change of nitroglycerin dosage, the change of score of Seattle angina pectoris and the change index of TCM syndromes were observed and recorded before and after the two groups were tested. The statistical results were obtained by SPSS 17.0 program. Results: after treatment, angina pectoris, electrocardiogram (ECG), nitroglycerin dosage, syndromes of TCM Syndromes, total score of syndrome and score of Seattle scale were improved, and the treatment group was superior to the control group (P0.01 or P0.05). The scores of TCM single symptoms in the treatment group were significantly lower than those in the former group (P0.01), while the single score in the control group (excluding insomnia) was significantly different from that in the control group (P0.01). The decrease of tongue coating was statistically significant (P0.01 or P0.05), and the single score (except shortness of breath and insomnia) in the treatment group was lower than that in the control group (P0.05). No safety indicators and adverse reactions were recorded during the experiment. Conclusion: Sanqi Zhitong prescription combined with western medicine can significantly improve the clinical symptoms of patients with stable angina pectoris with phlegm and blood stasis syndrome, and is superior to the effect of western medicine alone, and its clinical application is safe and reliable.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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