定痛汤治疗青春期寒凝血瘀型原发性痛经的临床研究

发布时间：2018-08-03 20:56

【摘要】：目的：本课题旨在通过观察定痛汤在治疗青春期寒凝血瘀型原发性痛经的临床疗效,客观地评价定痛汤治疗本病的有效性及其对血清CA125的影响,以期对定痛汤疗效有进一步的认识。方法：采用随机分组方法将60例寒凝血瘀型原发性痛经的青春期患者分为治疗组和对照组2组,每组各30例。治疗组口服定痛汤治疗,对照组口服“月月舒”痛经宝颗粒治疗。通过观察患者用药前和用药1个疗程(3个月经周期)后的临床症状改善情况,采用积分法,比较患者的症状和血清CA125结果。结果：1.两组患者共60例,治疗前在年龄、病程、痛经程度、中医证候积分及血清CA125值均无明显差异(P0.05)；治疗一个疗程后,两组痛经程度分值均下降,治疗组下降更明显,且组间比较差异有显著性(P0.05);2.痛经程度总疗效比较：治疗一个疗程后,治疗组痛经程度改善总有效率为90%,对照组总有效率为86.67%,两组比较差异有统计学意义(P0.05)；3.中医证候积分比较：治疗一个疗程后,治疗组与对照组中医证候积分较治疗前均有显著差异(P0.05),组间比较有显著差异(P0.05);4.中医证候疗效比较：治疗一个疗程后,治疗组总有效率为90.0%,对照组总有效率为73.33%,组间比较差异有统计学意义(P0.05)；5.血清CA125值：治疗一个疗程后,两组血清CA125值均下降,治疗组更明显,但组间比较无明显统计学差异(P0.05)。结论：经过本课题研究发现定痛汤疗效优于“月月舒”痛经宝颗粒,显示了中医辨证治疗本病的优越性,有一定的临床应用价值。
[Abstract]:Objective: to observe the clinical effect of Dingtong decoction on primary dysmenorrhea of puberty cold coagulation and blood stasis type, and to evaluate objectively the efficacy of Dingtong decoction in treating this disease and its effect on serum CA125. With a view to a further understanding of the efficacy of Dingtong decoction. Methods: 60 cases of primary dysmenorrhea with cold coagulation and blood stasis were randomly divided into treatment group and control group with 30 cases in each group. The treatment group was treated with Dingtong decoction and the control group was treated with Yueyuesu Tongjingbao granule. By observing the improvement of clinical symptoms before and after one course of treatment (3 menstrual cycles), the patients' symptoms and the results of serum CA125 were compared by integral method. The result is 1: 1. There were no significant differences in age, course of disease, degree of dysmenorrhea, TCM syndrome score and serum CA125 between the two groups before treatment (P0.05). After one course of treatment, the scores of dysmenorrhea degree decreased in both groups, especially in the treatment group. There was significant difference between groups (P0.05). Comparison of the total curative effect of dysmenorrhea: after a course of treatment, the total effective rate of improving the degree of dysmenorrhea in the treatment group was 90 and the total effective rate in the control group was 86.67. The difference between the two groups was statistically significant (P0.05). Comparison of TCM syndromes: after a course of treatment, there were significant differences in TCM syndrome scores between the treatment group and the control group (P0.05) and significant difference (P0.05) between the treatment group and the control group (P0.05). Comparison of TCM syndromes efficacy: after a course of treatment, the total effective rate of the treatment group was 90.0 and the total effective rate of the control group was 73.33. The difference between the two groups was statistically significant (P0.05). Serum CA125 value: after a course of treatment, the serum CA125 levels of the two groups decreased, especially in the treatment group, but there was no significant difference between the two groups (P0.05). Conclusion: Dingtong decoction is superior to "Yueyueshu" Tongjingbao granule through the research of this subject, which shows the superiority of TCM in treating this disease and has certain clinical application value.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.113

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