从阴阳自和角度论肝脏脂质代谢与细胞自噬的关系

发布时间：2018-08-04 17:26

【摘要】：自噬是机体内利用溶酶体降解自身受损细胞组分的过程,有利于机体内物质平衡和内环境稳态。在肝脏脂质代谢过程中,一方面细胞自噬的上调促进脂滴的分解,一方面自噬的下调则促进脂质的聚积,同时肝脏细胞脂质聚积也会对自噬产生负向调节。自噬对于肝脏脂质代谢的正向或者负向调节,从微观调控着体内的脂质稳态。阴阳自和是阴阳二者生理状态下自动维持平衡的能力,细胞自噬也是微环境的动态平衡。笔者试从中医阴阳自和角度论细胞自噬对于肝脏脂质代谢的影响,阐述从细胞自噬与阴阳自和理论指导肝脏脂质代谢紊乱治疗的现代意义。
[Abstract]:Autophagy is a process in which lysosomes are used to degrade the components of self-damaged cells, which is beneficial to the substance balance and homeostasis of the body. In the process of liver lipid metabolism, on the one hand, the up-regulation of autophagy promotes the decomposition of lipid droplets, on the other hand, the down-regulation of autophagy promotes the accumulation of lipid, at the same time, the accumulation of lipids in liver cells can also produce negative regulation on autophagy. Autophagy regulates lipid homeostasis in vivo microscopically. Yin-yang self-harmony is the ability to maintain the balance automatically in the physiological state of Yin-Yang, and autophagy is also the dynamic balance of microenvironment. This paper tries to discuss the effect of cellular autophagy on lipid metabolism of liver from the perspective of self-harmony of yin and yang in traditional Chinese medicine, and expounds the modern significance of guiding the treatment of liver lipid metabolism disorder from the theory of autophagy and self-harmony of yin and yang.
【作者单位】：辽宁中医药大学中医脏象理论及应用教育部重点实验室;辽宁省中医转化医学研究中心;
【基金】：国家自然科学基金项目(No.81202834) 辽宁省科学技术计划项目(No.2014225004) 辽宁省高等学校优秀人才支持计划(No.LR2015041) 辽宁省自然科学基金(No.2015020394) 辽宁中医药大学大学生创新创业训练计划(No.201510162000000)
【分类号】：R259

【相似文献】