加减毓麟汤治疗卵巢早衰脾肾阳虚证的临床研究

发布时间：2018-08-04 21:40

【摘要】：目的:观察加减毓麟汤治疗卵巢早衰脾肾阳虚证的临床疗效。方法:非随机非劣性对照研究方法,采集病例142例。治疗组(91例)予口服中药加减毓麟汤治疗,对照组(51例)予口服戊酸雌二醇片加黄体酮胶囊治疗,3个月为1个疗程,共治疗2个疗程。观察两组治疗前后中医证候积分,血清FSH、LH、E2及子宫三径之和改善情况。结果:综合疗效比较,治疗组总有效率(61.54%)优于对照组(43.14%)(P0.05);中医证候疗效比较,治疗组总有效率(49.45%)优于对照组(21.57%)(P0.05);治疗后两组FSH水平明显改善(P0.05,P0.01);治疗组治疗后LH水平较治疗前降低,E_2水平较治疗前升高(P0.05),子宫三径之和较治疗前无明显改善。结论:加减毓麟汤治疗卵巢早衰脾肾阳虚证疗效确切,可改善患者中医证候症状,可降低血清FSH、LH水平并升高E2水平。
[Abstract]:Objective: to observe the clinical effect of modified Yulin decoction on spleen and kidney yang deficiency syndrome of premature ovarian failure. Methods: 142 cases of non-random non-inferior control study were collected. The treatment group (91 cases) was treated with oral Chinese medicine plus Jiangyu Lin decoction, while the control group (51 cases) was treated with oral estradiol valerate tablet plus progesterone capsule, 3 months as a course of treatment, a total of 2 courses of treatment. The scores of TCM syndromes, the improvement of serum FSHLH2 and the sum of three uterine diameter before and after treatment were observed. Results: the total effective rate of the treatment group (61.54%) was better than that of the control group (43.14%) (P0.05). The total effective rate of the treatment group (49.45%) was better than that of the control group (21.57%) (P0.05), the level of FSH in the two groups was obviously improved after treatment (P0.05P0.01), the level of LH in the treatment group was lower than that before the treatment (P0.05), and the sum of three paths of uterus had no significant improvement compared with that before treatment. Conclusion: Yulin decoction is effective in treating the syndrome of deficiency of spleen and kidney yang in premature ovarian failure. It can improve the symptoms of TCM, decrease the level of serum FSHN LH and increase the level of E2.
【作者单位】：首都医科大学附属北京中医医院;宁波市第七医院;
【基金】：北京市科委“首都临床特色应用研究”项目(No.Z131107002213138) 北京市卫生系统高层次卫生技术人才培养计划专项(No.2013-2-028)~~
【分类号】：R271.9

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