益肾活血降浊方治疗糖尿病肾病对血清PTH水平影响的临床研究
发布时间：2018-08-05 12:01
【摘要】：目的:观察运用益肾活血降浊方治疗糖尿病肾病对血清PTH水平的影响,继而探讨中西医结合治疗本病的优势和可行性,以及此法对因糖尿病肾病而引发的早期骨病的预防作用。方法:选择糖尿病肾病Mogenson IV期患者60例,选用随机数字表法将符合要求的60位患者平均分成两组,治疗组(盖三淳+益肾活血降浊方组)30例,对照组(尿毒清+盖三淳)30例,两组患者均经过一般治疗控制血压、血糖等,对照组服用尿毒清+盖三淳,治疗组服用盖三淳外,加服以益肾活血降浊为治疗原则的中药方,服药周期8周,分别评价治疗前后患者临床症状改善情况及各项检查指标(PTH、BUN、Scr、血钙、血磷、血红蛋白和24h尿蛋白等)。结果采用SPSS17.0进行统计分析。P0.05,显示两组有差异,具有统计学意义。结果:经临床观察及统计学分析,治疗后中药治疗组在改善临床症状、降低PTH、稳定血糖、降低血肌酐、尿素氮、改善肾功、提高血红蛋白含量改善贫血、减少尿蛋白等方面明显优于对照组,且P0.05,具有统计学意义,治疗前后血、尿、便三大常规,肝功,心电图等无明显不符合病情的变化。益肾活血降浊方治疗糖尿病肾病及预防肾性骨病方面有明显疗效。结论:研究结果显示益肾活血降浊方在降低血清PTH水平,纠正钙磷代谢紊乱,预防肾性骨病的发生,降低尿毒素,改善肾功能,改善肾性贫血,降低尿蛋白,稳定血糖及有效延缓病情的进展等方面明显优于对照组,且安全性好。
[Abstract]:Objective: to observe the effect of Yishen Huoxue Jiangzhuo recipe on serum PTH level of diabetic nephropathy, and then to explore the advantages and feasibility of integrated traditional Chinese and western medicine in the treatment of this disease, and the preventive effect of this method on early bone disease caused by diabetic nephropathy. Methods: sixty patients with Mogenson IV stage diabetic nephropathy were randomly divided into two groups: the treatment group (Gesan Chun Yishen Huoxue Jiangzhuo) group (30 cases) and the control group (Miuduqing Qinggaicun 30 cases). The two groups were treated with general treatment to control blood pressure, blood sugar, etc. The control group was treated with UDQ and Gesan Chun, while the treatment group was treated with Gesanchun in addition to the traditional Chinese medicine prescription with the principle of tonifying kidney, activating blood circulation and lowering turbid. The treatment period was 8 weeks. To evaluate the improvement of clinical symptoms before and after treatment, and to evaluate the examination indexes (PTHU BUNScrs, blood calcium, serum phosphorus, hemoglobin and 24 hours urine protein, etc.). Results SPSS17.0 was used for statistical analysis. P 0.05, showing the difference between the two groups, with statistical significance. Results: after clinical observation and statistical analysis, the treatment group improved clinical symptoms, reduced PTH, stabilized blood glucose, reduced serum creatinine, urea nitrogen, improved renal function and hemoglobin content, and improved anemia. The decrease of urine protein was significantly better than that of the control group (P0.05). Before and after treatment, there were no significant changes in blood, urine, stool, liver function, electrocardiogram and so on. Yishen Huoxue Jiangzhuo recipe for diabetic nephropathy and the prevention of renal osteopathy has obvious effect. Conclusion: the results show that Yishen Huoxue Jiangzhuo prescription can reduce serum PTH level, correct calcium and phosphorus metabolism disorder, prevent renal osteopathy, decrease urinary toxin, improve renal function, improve renal anemia and reduce urinary protein. The stability of blood sugar and the delay of the progress of the disease were better than that of the control group, and the safety was good.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.5
[Abstract]:Objective: to observe the effect of Yishen Huoxue Jiangzhuo recipe on serum PTH level of diabetic nephropathy, and then to explore the advantages and feasibility of integrated traditional Chinese and western medicine in the treatment of this disease, and the preventive effect of this method on early bone disease caused by diabetic nephropathy. Methods: sixty patients with Mogenson IV stage diabetic nephropathy were randomly divided into two groups: the treatment group (Gesan Chun Yishen Huoxue Jiangzhuo) group (30 cases) and the control group (Miuduqing Qinggaicun 30 cases). The two groups were treated with general treatment to control blood pressure, blood sugar, etc. The control group was treated with UDQ and Gesan Chun, while the treatment group was treated with Gesanchun in addition to the traditional Chinese medicine prescription with the principle of tonifying kidney, activating blood circulation and lowering turbid. The treatment period was 8 weeks. To evaluate the improvement of clinical symptoms before and after treatment, and to evaluate the examination indexes (PTHU BUNScrs, blood calcium, serum phosphorus, hemoglobin and 24 hours urine protein, etc.). Results SPSS17.0 was used for statistical analysis. P 0.05, showing the difference between the two groups, with statistical significance. Results: after clinical observation and statistical analysis, the treatment group improved clinical symptoms, reduced PTH, stabilized blood glucose, reduced serum creatinine, urea nitrogen, improved renal function and hemoglobin content, and improved anemia. The decrease of urine protein was significantly better than that of the control group (P0.05). Before and after treatment, there were no significant changes in blood, urine, stool, liver function, electrocardiogram and so on. Yishen Huoxue Jiangzhuo recipe for diabetic nephropathy and the prevention of renal osteopathy has obvious effect. Conclusion: the results show that Yishen Huoxue Jiangzhuo prescription can reduce serum PTH level, correct calcium and phosphorus metabolism disorder, prevent renal osteopathy, decrease urinary toxin, improve renal function, improve renal anemia and reduce urinary protein. The stability of blood sugar and the delay of the progress of the disease were better than that of the control group, and the safety was good.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.5
【参考文献】
相关期刊论文 前10条
1 安淑云;;PTH、VitD3与2型糖尿病肾病的相关性研究[J];现代养生;2015年12期
2 田婷;陈华;冯亚龙;殷璐;陈丹倩;赵英永;林瑞超;;泽泻药理与毒理作用的研究进展[J];中药材;2014年11期
3 李颖;张秀珍;宣淼;杨军;计佩芳;刘海燕;;绝经后2型糖尿病妇女骨密度与PTH四项指标的临床分析[J];同济大学学报(医学版);2014年06期
4 刘亭亭;王萌;;女贞子化学成分与药理作用研究进展[J];中国实验方剂学杂志;2014年14期
5 张晓玲;白久旭;韩敬明;王东辉;崔汉民;曹宁;;糖尿病肾病与非糖尿病肾病维持性血液透析患者血钙、血磷及甲状旁腺激素水平的分析[J];现代生物医学进展;2013年30期
6 冯倩;邓德耀;袁文丽;;慢性肾脏病4～5期糖尿病与非糖尿病患者骨代谢指标分析[J];国际检验医学杂志;2012年24期
7 杨洪雁;杜智恒;白秀娟;;水蛭药理作用的研究进展[J];东北农业大学学报;2012年03期
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