加味柴芍六君颗粒对IBS-D肝郁脾虚证影响的观察
发布时间：2018-08-06 20:23
【摘要】：目的:观察导师李桂贤教授临床善用的加味柴芍六君颗粒治疗肝郁脾虚证IBS-D的临床有效性及安全性,并从理论上探讨该方治疗肠易激综合征的作用机制。方法:将广西中医药大学第一附属医院脾胃科门诊符合IBS-D肝郁脾虚证的60例患者,随机分为治疗组及对照组,每组各30例。对照组给予马来酸曲美布汀胶囊合复合乳酸菌胶囊治疗,治疗组在对照组用药基础上配合中药加味柴芍六君颗粒进行治疗,两组均治疗4周。疗程结束后,分别对两组进行门诊或电话随访。结果:1.治疗组中医证候积分与对照组比较,差异有统计学意义(P0.05),治疗组疗效明显优于对照组。2.治疗组治疗后痊愈8例,显效14例,有效5例,无效3例,总有效率为90.0%;对照组治疗后痊愈4例,显效7例,有效11例,无效6例,总有效率为78.6%,差异有统计学意义(P0.05),治疗组疗效明显优于对照组。3.治疗后两组患者在治疗腹泻、腹痛腹胀、嗳气、倦怠乏力、神疲懒言、食欲不振、寐差、口渴症状的有效率上,有显著性差异(P0.05),治疗组在治疗上述症状疗效上优于对照组。两组患者肠鸣症状治疗有效率无明显差异(P0.05)。4.治疗后治疗组患者IBS-SSS总积分及腹痛程度、腹痛时间、腹胀程度、大便满意度、生活影响度疗效上均优于对照组(P0.05)。5.治疗后治疗组患者生活质量总积分及各维度单项积分均优于对照组(P0.05)。6.疗程结束3个月对两组病人进行电话或门诊随访,治疗组复发5例,未复发22例,复发率18.5%;对照组复发11例,未复发11例,复发率50.0%。经统计两组复发率有显著性差异(P0.05),治疗组复发率明显低于对照组。结论:加味柴芍六君颗粒联合西药治疗肝郁脾虚证IBS-D疗效确切,安全性好,复发率低且无不良反应,能明显缓解IBS-D腹泻、腹胀、腹痛、肠鸣、嗳气、倦怠乏力、神疲懒言、食欲不振、寐差、口渴症状,提高IBS-D患者的生活质量。
[Abstract]:Objective: to observe the clinical efficacy and safety of modified Chaixiaoxiujun granule, a tutor of Professor Li Guixian, in the treatment of IBS-D with liver stagnation and spleen deficiency, and to explore theoretically the mechanism of the treatment of irritable bowel syndrome. Methods: sixty patients with IBS-D liver depression and spleen deficiency syndrome were randomly divided into treatment group and control group, each group with 30 cases in the outpatient department of spleen and stomach of the first affiliated Hospital of Guangxi University of traditional Chinese Medicine. The control group was treated with trimebutine maleate capsule combined with lactic acid bacteria capsule, and the treatment group was treated with traditional Chinese medicine plus Chaixiaoniujun granule on the basis of drug use in the control group. Both groups were treated for 4 weeks. After the course of treatment, the two groups were followed up by telephone or outpatient. The result is 1: 1. The treatment group compared with the control group TCM syndrome score, the difference was statistically significant (P0.05), the treatment group was significantly better than the control group. 2. In the treatment group, 8 cases were cured, 14 cases were effective, 5 cases were effective, 3 cases were ineffective, the total effective rate was 90.0%, while in the control group, 4 cases were cured, 7 cases were markedly effective, 11 cases were effective, 6 cases were ineffective. The total effective rate was 78.6, the difference was statistically significant (P0.05), the curative effect of the treatment group was significantly better than that of the control group. 3. After treatment, there were significant differences between the two groups in the effective rate of treating diarrhea, abdominal pain, belching, fatigue, listlessness, anorexia, insomnia and thirst (P0.05). The therapeutic effect of the treatment group was better than that of the control group. There was no significant difference between the two groups (P0.05). After treatment, the total score of IBS-SSS, the degree of abdominal pain, the time of abdominal pain, the degree of abdominal distension, the degree of stool satisfaction and the degree of influence of life in the treatment group were better than those in the control group (P0.05). After treatment, the total score of quality of life and the single score of each dimension in the treatment group were superior to those in the control group (P0.05). 6. The two groups were followed up by telephone or outpatient at the end of 3 months. The recurrence rate was 18.5in the treatment group (n = 5), but in the control group (n = 11), no recurrence occurred (n = 11), the recurrence rate was 50.0%. There was significant difference in the recurrence rate between the two groups (P0.05), and the recurrence rate in the treatment group was significantly lower than that in the control group. Conclusion: Jiawei Chaixiaolijun granule combined with western medicine is effective and safe in the treatment of liver depression and spleen deficiency syndrome IBS-D with low recurrence rate and no adverse reactions. It can obviously relieve IBS-D diarrhea, abdominal distension, abdominal pain, bowel ringing, belching, fatigue, fatigue and laziness, and can relieve IBS-D diarrhea, abdominal distension, abdominal pain, intestinal pain, belching, fatigue, fatigue and laziness. Loss of appetite, poor sleep, thirst symptoms, improve the quality of life of patients with IBS-D.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
本文编号：2168891
[Abstract]:Objective: to observe the clinical efficacy and safety of modified Chaixiaoxiujun granule, a tutor of Professor Li Guixian, in the treatment of IBS-D with liver stagnation and spleen deficiency, and to explore theoretically the mechanism of the treatment of irritable bowel syndrome. Methods: sixty patients with IBS-D liver depression and spleen deficiency syndrome were randomly divided into treatment group and control group, each group with 30 cases in the outpatient department of spleen and stomach of the first affiliated Hospital of Guangxi University of traditional Chinese Medicine. The control group was treated with trimebutine maleate capsule combined with lactic acid bacteria capsule, and the treatment group was treated with traditional Chinese medicine plus Chaixiaoniujun granule on the basis of drug use in the control group. Both groups were treated for 4 weeks. After the course of treatment, the two groups were followed up by telephone or outpatient. The result is 1: 1. The treatment group compared with the control group TCM syndrome score, the difference was statistically significant (P0.05), the treatment group was significantly better than the control group. 2. In the treatment group, 8 cases were cured, 14 cases were effective, 5 cases were effective, 3 cases were ineffective, the total effective rate was 90.0%, while in the control group, 4 cases were cured, 7 cases were markedly effective, 11 cases were effective, 6 cases were ineffective. The total effective rate was 78.6, the difference was statistically significant (P0.05), the curative effect of the treatment group was significantly better than that of the control group. 3. After treatment, there were significant differences between the two groups in the effective rate of treating diarrhea, abdominal pain, belching, fatigue, listlessness, anorexia, insomnia and thirst (P0.05). The therapeutic effect of the treatment group was better than that of the control group. There was no significant difference between the two groups (P0.05). After treatment, the total score of IBS-SSS, the degree of abdominal pain, the time of abdominal pain, the degree of abdominal distension, the degree of stool satisfaction and the degree of influence of life in the treatment group were better than those in the control group (P0.05). After treatment, the total score of quality of life and the single score of each dimension in the treatment group were superior to those in the control group (P0.05). 6. The two groups were followed up by telephone or outpatient at the end of 3 months. The recurrence rate was 18.5in the treatment group (n = 5), but in the control group (n = 11), no recurrence occurred (n = 11), the recurrence rate was 50.0%. There was significant difference in the recurrence rate between the two groups (P0.05), and the recurrence rate in the treatment group was significantly lower than that in the control group. Conclusion: Jiawei Chaixiaolijun granule combined with western medicine is effective and safe in the treatment of liver depression and spleen deficiency syndrome IBS-D with low recurrence rate and no adverse reactions. It can obviously relieve IBS-D diarrhea, abdominal distension, abdominal pain, bowel ringing, belching, fatigue, fatigue and laziness, and can relieve IBS-D diarrhea, abdominal distension, abdominal pain, intestinal pain, belching, fatigue, fatigue and laziness. Loss of appetite, poor sleep, thirst symptoms, improve the quality of life of patients with IBS-D.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
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