手指末端生物光子辐射与肺气虚证、痰热壅肺证的相关性研究

发布时间：2018-08-07 15:07

【摘要】：研究目的:本课题在课题组前期搭建人体超微弱发光检测平台的基础上,优化人体手指末端生物发光的检测技术指标,并基于人体生物光子理论研究手指末端生物光子辐射与肺气虚证、痰热壅肺证的相关性。研究内容:以肺气虚证和痰热壅肺证为研究对象,以健康人为对照组,利用人体超微弱发光检测系统,检测人体手指末端的生物发光强度,研究手指生物光子辐射与肺气虚证和痰热壅肺证的相关性,探讨肺气虚证、痰热壅肺证定量化判别的可行性。研究结果:基于人体光子辐射的量子态特征通过公式拟合,应用MATLAB软件分析获得12个生物光子辐射特征指标,分别为Mean、VAR、Intercept、slope、Q、Fano、α、γ、θ、φ、SSI、SSR。通过探讨手指末端生物发光特征指标的变化,发现肺气虚证组与健康组、痰热壅肺证与健康组、肺气虚证组与痰热壅肺证组存在差异性。进一步对肺气虚证组、痰热壅肺证与健康组进行定量化可行性分析,研究结果发现BP神经网络能较好的区分肺气虚证组与健康组、痰热壅肺证组与健康组、肺气虚证组与痰热壅肺证组,各组的判别正确率都在80%以上。为了进一步验证此结果,我们选用判别分析方法再次对肺气虚证组、痰热壅肺证组与健康人组进行判别分析,判别正确率也均在75%以上。运用ROC曲线方法筛选出能较好表征肺气虚证组与健康组、痰热壅肺证组与健康组的生物光子辐射的判别指标。结论:通过检测手指末端生物光子辐射强度、分析生物光子辐射特征指标的变化发现肺气虚证组与健康组、痰热壅肺证与健康组、肺气虚证组与痰热壅肺证组存在差异性。运用不同判别方法对肺气虚证组、痰热壅肺证组与健康组进行判别分类,发现基于手指末端生物光子辐射的参数指标能够较好的区分肺气虚证组、痰热壅肺证组与健康组。提示手指末端生物光子辐射能够用于中医证候的相关性研究,为中医证候的定量化研究提供一种可行性手段。
[Abstract]:Objective: to optimize the bioluminescence detection technology of human finger end on the basis of setting up the human ultra-weak luminescence detection platform in the early stage of the research group. On the basis of human biological photon theory, the correlation between biological photon radiation at the end of finger and lung qi deficiency syndrome and phlegm heat blocking lung syndrome was studied. Research contents: taking lung qi deficiency syndrome and phlegm heat blocking lung syndrome as research objects, and taking healthy people as control group, the bioluminescence intensity at the end of human finger was detected by using the human body ultraweak luminescence detection system. To study the correlation between biological photon radiation of fingers and lung qi deficiency syndrome and phlegm heat blocking lung syndrome, and to explore the feasibility of quantitative discrimination of lung qi deficiency syndrome and phlegm heat blocking lung syndrome. Results: based on the formula fitting of the quantum state characteristics of human photon radiation, 12 biological photon radiation characteristic indexes were obtained by MATLAB software, namely, mean VARA Interceptor SSRs, 伪, 纬, 胃 and 蠁 SSRs. Through the study of the changes of bioluminescence characteristics at the end of the finger, it was found that there were differences between the lung qi deficiency syndrome group and the healthy group, the phlegm heat stagnation lung syndrome group and the healthy group, the lung qi deficiency syndrome group and the phlegm heat stagnation lung syndrome group. Further quantitative feasibility analysis of lung qi deficiency syndrome group, phlegm heat stagnation lung syndrome group and healthy group was carried out. The results showed that BP neural network could distinguish between lung qi deficiency syndrome group and healthy group, phlegm heat accumulation lung syndrome group and healthy group. The correct rate of differentiation of lung qi deficiency group and phlegm heat blocking lung syndrome group were above 80%. In order to further verify this result, we used the discriminant analysis method again to the lung qi deficiency syndrome group, phlegm heat obstruction lung syndrome group and healthy people group, the discriminant accuracy was above 75%. The ROC curve was used to screen out the discriminant indexes of biological photon radiation which could better characterize the lung qi deficiency syndrome group and healthy group, phlegm heat stagnation lung syndrome group and healthy group. Conclusion: by detecting the biological photon radiation intensity at the end of the finger and analyzing the change of biological photon radiation characteristic index, it is found that there are differences between the lung qi deficiency syndrome group and the healthy group, the phlegm heat stagnation lung syndrome group and the healthy group, the lung qi deficiency syndrome group and the phlegm heat stagnation lung syndrome group. Different discriminant methods were used to distinguish lung qi deficiency syndrome group, phlegm heat obstruction lung syndrome group and healthy group. It was found that the parameter indexes based on biological photon radiation at the end of finger could distinguish between lung qi deficiency syndrome group, phlegm heat stagnation lung syndrome group and healthy group. It is suggested that biological photon radiation at the end of finger can be used to study the correlation of TCM syndromes and provide a feasible means for the quantitative study of TCM syndromes.
【学位授予单位】：山东中医药大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：R259

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