益肾清利活血法治疗慢性肾小球肾炎的临床研究
发布时间：2018-08-07 17:35
【摘要】：目的:探讨益肾清利活血法治疗慢性肾小球肾炎的临床疗效。方法:选取2012年6月—2016年6月医院收治的慢性肾小球肾炎患者81例,根据入院时间,将其分为两组,对照组(n=40)和观察组(n=41)。对照组采取常规治疗基础上,再用肾炎康复片和百令胶囊进行治疗;观察组在对照组基础上,加用补肾清利活血汤进行治疗。比较两组治疗后的临床疗效,肾功能(BUN、SCr),24 h尿蛋白定量(UTP),中医证候积分改变情况,实验室指标及不良反应。结果:治疗后,对照组总有效率为80.00%,观察组总有效率为90.24%,观察组临床效果优于对照组,差异显著(P0.05);治疗后,两组BUN,SCr、UTP和尿红细胞计数(URBC)水平均下降,观察组BUN,SCr、UTP及URBC水平下降程度优于对照组,中医证候积分明显低于对照组,差异均具有统计学意义(P0.05)。但两组血脂(TC、TG、LDL-C)、血尿酸(UA)、血白蛋白(ALB)水平,治疗前后无明显差异,无统计学意义(P0.05)。结论:益肾清利活血法治疗慢性肾小球肾炎的临床疗效显著,可使患者肾功能、临床体征得以有效改善,值得在临床上进一步推广应用。
[Abstract]:Objective: to investigate the clinical effect of Yishen Qingli Huoxue method on chronic glomerulonephritis. Methods: 81 patients with chronic glomerulonephritis from June 2012 to June 2016 were divided into two groups: control group (n = 40) and observation group (n = 41). On the basis of routine treatment, the control group was treated with nephritis rehabilitation tablet and bailing capsule, while the observation group was treated with Bushen Qingli Huoxue decoction on the basis of control group. To compare the clinical effect of the two groups, the changes of TCM syndromes, laboratory indexes and adverse reactions of 24 h urinary protein quantitative (UTP), in renal function (Bung SCr). Results: after treatment, the total effective rate of the control group was 80.00g and the total effective rate of the observation group was 90.24B. the clinical effect of the observation group was better than that of the control group, the difference was significant (P0.05). The levels of UTP and URBC in the observation group were significantly lower than those in the control group (P0.05), and the TCM syndromes score was significantly lower than that in the control group (P0.05). However, there was no significant difference between the two groups before and after treatment (P0.05) in the levels of serum lipids (TC) and serum uric acid (UA),) albumin (ALB) levels before and after treatment. Conclusion: the treatment of chronic glomerulonephritis with Yishen Qingli Huoxue method has remarkable clinical effect and can effectively improve the renal function and clinical signs of the patients. It is worth further popularizing and applying in clinic.
【作者单位】： 浙江省立同德医院肾病科;
【基金】：浙江省中医药科学研究基金计划项目(2013ZB006)
【分类号】：R277.5
[Abstract]:Objective: to investigate the clinical effect of Yishen Qingli Huoxue method on chronic glomerulonephritis. Methods: 81 patients with chronic glomerulonephritis from June 2012 to June 2016 were divided into two groups: control group (n = 40) and observation group (n = 41). On the basis of routine treatment, the control group was treated with nephritis rehabilitation tablet and bailing capsule, while the observation group was treated with Bushen Qingli Huoxue decoction on the basis of control group. To compare the clinical effect of the two groups, the changes of TCM syndromes, laboratory indexes and adverse reactions of 24 h urinary protein quantitative (UTP), in renal function (Bung SCr). Results: after treatment, the total effective rate of the control group was 80.00g and the total effective rate of the observation group was 90.24B. the clinical effect of the observation group was better than that of the control group, the difference was significant (P0.05). The levels of UTP and URBC in the observation group were significantly lower than those in the control group (P0.05), and the TCM syndromes score was significantly lower than that in the control group (P0.05). However, there was no significant difference between the two groups before and after treatment (P0.05) in the levels of serum lipids (TC) and serum uric acid (UA),) albumin (ALB) levels before and after treatment. Conclusion: the treatment of chronic glomerulonephritis with Yishen Qingli Huoxue method has remarkable clinical effect and can effectively improve the renal function and clinical signs of the patients. It is worth further popularizing and applying in clinic.
【作者单位】： 浙江省立同德医院肾病科;
【基金】：浙江省中医药科学研究基金计划项目(2013ZB006)
【分类号】：R277.5
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