还脑益聪方改善脑卒中后认知功能障碍的疗效
发布时间：2018-08-09 10:49
【摘要】：目的探讨还脑益聪方(HYD)改善脑卒中后认知功能障碍的疗效、安全性及其可能作用机制。方法 100例脑卒中后认知功能障碍(PCI)的患者随机分为两组:对照组(50例)给予常规治疗,吡拉西坦片0.8/次,3次/d,口服;盐酸多奈哌齐胶囊,5 mg/次,1次/d,4 w后增至10 mg/次,1次/d。观察组(50例)在对照组治疗基础上加用HYD中药免煎颗粒口服。两组均连续治疗12 w。治疗前后检测两组患者认知功能[蒙特利尔认知评估量表(MoCA)、简易智能检查量表(MMSE)、日常生活活动能力(ADL)评分]及生化指标[总胆固醇(TC)、甘油三酯(TG)、同型半胱氨酸(Hcy)、白细胞介素(IL)-6、超氧化物歧化酶(SOD)、丙二醛(MDA)和乙酰胆碱酯酶(AchE)]。结果治疗12 w后,两组患者的MoCA、MMSE及ADL评分、TC、TG、Hcy、IL-6、SOD、MDA和AchE水平均较治疗前明显改善(P0.05或P0.01),且观察组患者改善更显著(P0.05或P0.01)。口服HYD中药免煎颗粒未出现明显的不良反应。结论 HYD能显著改善脑卒中后认知功能障碍,提高患者日常生活自理能力,安全性好,作用机制可能与其调脂、抗炎、抗动脉粥样硬化及提高乙酰胆碱活性有关。
[Abstract]:Objective to investigate the efficacy, safety and possible mechanism of Huanao Yicong recipe (HYD) in improving cognitive dysfunction after stroke. Methods one hundred patients with cognitive dysfunction (PCI) after stroke were randomly divided into two groups: the control group (50 cases) received routine treatment, Piracetam was given 0.8d / d, and Donepezil capsule was increased to 10 mg/ times per day after 4 weeks. Observation group (50 cases) in the control group on the basis of treatment plus HYD Chinese medicine decoction oral. Both groups were treated continuously for 12 weeks. Cognitive function was measured before and after treatment [Montreal Cognitive Assessment scale (MoCA), mini-intelligence scale (MMSE), activity of daily living (ADL) score] and biochemical indexes [total cholesterol (TC), triglyceride (TG), homocysteine (Hcy),] and biochemistry index [total cholesterol (TC), triglyceride (TG), homocysteine (Hcy),] Interleukin (IL)-6, superoxide dismutase (SOD), malondialdehyde (MDA) and acetylcholinesterase (AchE)]. Results after 12 weeks of treatment, the levels of MMSE and ADL in both groups were significantly improved compared with those before treatment (P0.05 or P0.01), and the improvement was more significant in the observation group (P0.05 or P0.01). There was no obvious adverse reaction in oral HYD granules. Conclusion HYD can significantly improve cognitive dysfunction and self-care ability in daily life of patients with stroke. The mechanism of HYD may be related to its lipid regulation, anti-inflammation, anti-atherosclerosis and increased acetylcholine activity.
【作者单位】： 河南省平舆县中医院内一科;
【分类号】：R277.7
本文编号：2173843
[Abstract]:Objective to investigate the efficacy, safety and possible mechanism of Huanao Yicong recipe (HYD) in improving cognitive dysfunction after stroke. Methods one hundred patients with cognitive dysfunction (PCI) after stroke were randomly divided into two groups: the control group (50 cases) received routine treatment, Piracetam was given 0.8d / d, and Donepezil capsule was increased to 10 mg/ times per day after 4 weeks. Observation group (50 cases) in the control group on the basis of treatment plus HYD Chinese medicine decoction oral. Both groups were treated continuously for 12 weeks. Cognitive function was measured before and after treatment [Montreal Cognitive Assessment scale (MoCA), mini-intelligence scale (MMSE), activity of daily living (ADL) score] and biochemical indexes [total cholesterol (TC), triglyceride (TG), homocysteine (Hcy),] and biochemistry index [total cholesterol (TC), triglyceride (TG), homocysteine (Hcy),] Interleukin (IL)-6, superoxide dismutase (SOD), malondialdehyde (MDA) and acetylcholinesterase (AchE)]. Results after 12 weeks of treatment, the levels of MMSE and ADL in both groups were significantly improved compared with those before treatment (P0.05 or P0.01), and the improvement was more significant in the observation group (P0.05 or P0.01). There was no obvious adverse reaction in oral HYD granules. Conclusion HYD can significantly improve cognitive dysfunction and self-care ability in daily life of patients with stroke. The mechanism of HYD may be related to its lipid regulation, anti-inflammation, anti-atherosclerosis and increased acetylcholine activity.
【作者单位】： 河南省平舆县中医院内一科;
【分类号】：R277.7
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1 孙海蛟;;盐酸多奈哌齐配合四神针治疗老年性痴呆临床疗效观察[J];当代医学;2013年03期
，本文编号：2173843
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