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化浊剔络方对老年高脂血症痰瘀互结证临床疗效及炎性因子的研究

发布时间:2018-08-09 12:08
【摘要】:目的观察化浊剔络方治疗老年高脂血症属痰瘀互结证在中医症状积分、血脂指标(TC、TG、LDL、HDL)、炎性因子(hs-CRP、IL-6、TNF-α)等方面的临床疗效,并评估其安全性,为中医药治疗老年高脂血症提供新的诊治思路。方法本试验共纳入60例确诊符合老年高脂血症西医诊断标准及痰瘀互结证中医诊断标准的患者,按随机对照的方法分为观察组和对照组,两组各30人,对照组给予阿托伐他汀钙片,观察组予化浊剔络方联合阿托伐他汀钙片,中药煎剂口服,两组观察疗程均为4周。观察两组治疗前后中医症状积分、TC、TG、LDL、HDL、hs-CRP、IL-6、TNF-α等指标的变化,以及判定患者的不良反应和安全性。最后全部数据以SPSS19.0统计软件进行统计分析。结果观察组与对照组的年龄、性别、中医症状积分、血脂指标、炎症因子等基线比较均无显著统计学差异(P0.05),两组具有可比性。中医症状积分比较:两组患者治疗后中医症状积分均有明显下降(P0.05),观察组较对照组有显著差异(P0.05);症候疗效方面:观察组总有效率为96.3%,对照组总有效率为73.3%,有明显统计学差异(P0.05)。降脂效果及西医临床疗效分析:观察组及对照组患者治疗后TC、TG、LDL、HDL均有明显改善(P0.01),两组间治疗后比较,观察组TC、LDL改善较对照组有显著差异(P0.05),TG、HDL改善无明显差异(P0.05);疗效分析:观察组总有效率为86.7%,对照组总有效率为80%,两组降脂效果无明显差异(P0.05)。炎症因子比较:两组患者治疗后hs-CRP、IL-6水平较治疗前明显下降,hs-CRP、IL-6与治疗前比较有显著性差异(P0.05),TNF-α无明显差异(P0.05);两组治疗后比较:hs-CRP、IL-6有差异(P0.05),TNF-α无统计学差异(P0.05)。整个研究过程中患者未出现不良反应。结论1.化浊剔络方能有效的改善老年高脂血症中医临床症状。2.化浊剔络方能改善老年高脂血症痰瘀互结证患者TC、LDL的水平。3.化浊剔络方能降低老年高脂血症痰瘀互结证患者hs-CRP、IL-6的水平。4.化浊剔络方治疗老年高脂血症是安全及有效的。
[Abstract]:Objective to observe the clinical efficacy of Huazhuo Tiluo recipe in treating senile hyperlipidemia with phlegm and blood stasis syndromes in the aspects of TCM symptom score, blood lipid index (TCU TGG LDLX HDL), and inflammatory factor (hs-CRPU IL-6 TNF- 伪), and to evaluate its safety. To provide a new way of diagnosis and treatment for senile hyperlipidemia with traditional Chinese medicine. Methods A total of 60 patients with hyperlipidemia diagnosed by western medicine and TCM diagnostic criteria of phlegm and blood stasis syndromes were included in this study. The patients were divided into observation group and control group according to the method of random control, with 30 patients in each group. The control group was given Atto vastatin calcium tablet, the observation group was treated with Huazhuo Tiluo recipe combined with Atto vastatin calcium tablet, and the traditional Chinese medicine decoction was taken orally. The course of treatment was 4 weeks in both groups. Before and after treatment, the changes of TCM symptom scores and the changes of HDLHs-CRPPIL-6 TNF- 伪 were observed, and the adverse reactions and safety of the patients were evaluated. Finally, all the data are analyzed by SPSS19.0 statistical software. Results there was no significant difference between the two groups in age, sex, TCM symptom score, blood lipid index, inflammatory factors and other baseline (P0.05), the two groups were comparable. TCM symptom score comparison: two groups of patients after treatment of TCM symptom scores were significantly decreased (P0.05), the observation group than the control group has a significant difference (P0.05); symptom efficacy: the observation group total effective rate was 96.3G, the control group total effective rate was 73.3cm, there was significant statistical difference (P0.05). Analysis of the effect of lowering fat and clinical curative effect of western medicine: the patients in the observation group and the control group were significantly improved in HDL after treatment (P0.01), and the comparison was made between the two groups after treatment. Compared with the control group, the improvement of TCU LDL in the observation group was significantly different from that in the control group (P0.05). There was no significant difference in the improvement of TGG HDL (P0.05); the total effective rate of the observation group was 86.7%, the total effective rate of the control group was 80%, and there was no significant difference between the two groups (P0.05). Comparison of inflammatory factors: after treatment, the level of hs-CRPnil IL-6 in two groups was significantly lower than that before treatment (P0.05). There was no significant difference in TNF- 伪 between the two groups (P0.05), and there was no significant difference between the two groups after treatment (P0.05). No adverse reactions were observed throughout the study. Conclusion 1. Huazhuo Tiluo recipe can effectively improve the elderly hyperlipidemia clinical symptoms. 2. Huazhuo Tiluo recipe can improve the level of TCU LDL in senile hyperlipidemia patients with phlegm and blood stasis syndrome. Huazhuo Tiluo recipe can reduce the level of hs-CRPU IL-6 in senile hyperlipidemia patients with phlegm and blood stasis syndrome. 4. Huazhuo Tiluo recipe is safe and effective in the treatment of senile hyperlipidemia.
【学位授予单位】:南京中医药大学
【学位级别】:硕士
【学位授予年份】:2017
【分类号】:R259

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