化浊剔络方对老年高脂血症痰瘀互结证临床疗效及炎性因子的研究

发布时间：2018-08-09 12:08

【摘要】：目的观察化浊剔络方治疗老年高脂血症属痰瘀互结证在中医症状积分、血脂指标(TC、TG、LDL、HDL)、炎性因子(hs-CRP、IL-6、TNF-α)等方面的临床疗效,并评估其安全性,为中医药治疗老年高脂血症提供新的诊治思路。方法本试验共纳入60例确诊符合老年高脂血症西医诊断标准及痰瘀互结证中医诊断标准的患者,按随机对照的方法分为观察组和对照组,两组各30人,对照组给予阿托伐他汀钙片,观察组予化浊剔络方联合阿托伐他汀钙片,中药煎剂口服,两组观察疗程均为4周。观察两组治疗前后中医症状积分、TC、TG、LDL、HDL、hs-CRP、IL-6、TNF-α等指标的变化,以及判定患者的不良反应和安全性。最后全部数据以SPSS19.0统计软件进行统计分析。结果观察组与对照组的年龄、性别、中医症状积分、血脂指标、炎症因子等基线比较均无显著统计学差异(P0.05),两组具有可比性。中医症状积分比较:两组患者治疗后中医症状积分均有明显下降(P0.05),观察组较对照组有显著差异(P0.05);症候疗效方面:观察组总有效率为96.3%,对照组总有效率为73.3%,有明显统计学差异(P0.05)。降脂效果及西医临床疗效分析:观察组及对照组患者治疗后TC、TG、LDL、HDL均有明显改善(P0.01),两组间治疗后比较,观察组TC、LDL改善较对照组有显著差异(P0.05),TG、HDL改善无明显差异(P0.05);疗效分析:观察组总有效率为86.7%,对照组总有效率为80%,两组降脂效果无明显差异(P0.05)。炎症因子比较:两组患者治疗后hs-CRP、IL-6水平较治疗前明显下降,hs-CRP、IL-6与治疗前比较有显著性差异(P0.05),TNF-α无明显差异(P0.05);两组治疗后比较:hs-CRP、IL-6有差异(P0.05),TNF-α无统计学差异(P0.05)。整个研究过程中患者未出现不良反应。结论1.化浊剔络方能有效的改善老年高脂血症中医临床症状。2.化浊剔络方能改善老年高脂血症痰瘀互结证患者TC、LDL的水平。3.化浊剔络方能降低老年高脂血症痰瘀互结证患者hs-CRP、IL-6的水平。4.化浊剔络方治疗老年高脂血症是安全及有效的。
[Abstract]:Objective to observe the clinical efficacy of Huazhuo Tiluo recipe in treating senile hyperlipidemia with phlegm and blood stasis syndromes in the aspects of TCM symptom score, blood lipid index (TCU TGG LDLX HDL), and inflammatory factor (hs-CRPU IL-6 TNF- 伪), and to evaluate its safety. To provide a new way of diagnosis and treatment for senile hyperlipidemia with traditional Chinese medicine. Methods A total of 60 patients with hyperlipidemia diagnosed by western medicine and TCM diagnostic criteria of phlegm and blood stasis syndromes were included in this study. The patients were divided into observation group and control group according to the method of random control, with 30 patients in each group. The control group was given Atto vastatin calcium tablet, the observation group was treated with Huazhuo Tiluo recipe combined with Atto vastatin calcium tablet, and the traditional Chinese medicine decoction was taken orally. The course of treatment was 4 weeks in both groups. Before and after treatment, the changes of TCM symptom scores and the changes of HDLHs-CRPPIL-6 TNF- 伪 were observed, and the adverse reactions and safety of the patients were evaluated. Finally, all the data are analyzed by SPSS19.0 statistical software. Results there was no significant difference between the two groups in age, sex, TCM symptom score, blood lipid index, inflammatory factors and other baseline (P0.05), the two groups were comparable. TCM symptom score comparison: two groups of patients after treatment of TCM symptom scores were significantly decreased (P0.05), the observation group than the control group has a significant difference (P0.05); symptom efficacy: the observation group total effective rate was 96.3G, the control group total effective rate was 73.3cm, there was significant statistical difference (P0.05). Analysis of the effect of lowering fat and clinical curative effect of western medicine: the patients in the observation group and the control group were significantly improved in HDL after treatment (P0.01), and the comparison was made between the two groups after treatment. Compared with the control group, the improvement of TCU LDL in the observation group was significantly different from that in the control group (P0.05). There was no significant difference in the improvement of TGG HDL (P0.05); the total effective rate of the observation group was 86.7%, the total effective rate of the control group was 80%, and there was no significant difference between the two groups (P0.05). Comparison of inflammatory factors: after treatment, the level of hs-CRPnil IL-6 in two groups was significantly lower than that before treatment (P0.05). There was no significant difference in TNF- 伪 between the two groups (P0.05), and there was no significant difference between the two groups after treatment (P0.05). No adverse reactions were observed throughout the study. Conclusion 1. Huazhuo Tiluo recipe can effectively improve the elderly hyperlipidemia clinical symptoms. 2. Huazhuo Tiluo recipe can improve the level of TCU LDL in senile hyperlipidemia patients with phlegm and blood stasis syndrome. Huazhuo Tiluo recipe can reduce the level of hs-CRPU IL-6 in senile hyperlipidemia patients with phlegm and blood stasis syndrome. 4. Huazhuo Tiluo recipe is safe and effective in the treatment of senile hyperlipidemia.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

【相似文献】

相关期刊论文 前10条

1 李丽,徐方运,贾海蓉;复方丹参滴丸对老年高脂血症患者降脂抗栓的作用[J];中华老年医学杂志;2003年11期

2 张吉楼,刘英;京必舒新治疗老年高脂血症疗效观察[J];心脑血管病防治;2003年01期

3 邓仁生;邓新强;;清芝灵治疗老年高脂血症的疗效观察[J];临床和实验医学杂志;2007年07期

4 陈太峰;老年高脂血症的辨治探析[J];镇江医学院学报;1995年04期

5 蒋理,文怡;老年高脂血症患者血清中活化态转化生长因子β1的测定[J];中华老年医学杂志;1999年06期

6 杨惠民,田金洲,朱爱华,盛彤,韩丽蓓,胡玉宁,杨承芝,刘桓,钟剑;精明丹冲剂治疗老年高脂血症临床研究[J];北京中医药大学学报;2000年06期

7 赵联远,韩立秀,朱光耀;辛伐他丁治疗老年高脂血症临床疗效观察[J];现代康复;2000年13期

8 项阳,竺清渝,王宝恩;老年高脂血症患者血流变测定分析[J];首都医药;2000年03期

9 洪鸣鸣,陈瑾;不同剂量的辛伐他丁治疗老年高脂血症的观察[J];中国现代应用药学;2001年02期

10 江钟立;老年高脂血症康复[J];实用老年医学;2001年02期

相关会议论文 前9条

1 俞娉;李利;;可定治疗老年高脂血症30例疗效观察[A];中华医学会第十次全国内分泌学学术会议论文汇编[C];2011年

2 刘熙平;符献琼;;苦荞治疗老年高脂血症临床观察[A];中国营养学会第七届全国营养学术会议论文摘要汇编[C];1996年

3 刘志刚;孙宜芬;;他汀类与诺贝特类联合治疗混合型老年高脂血症临床观察[A];中华医学会心血管病学分会第八次全国心血管病学术会议汇编[C];2006年

4 苗懿德;刘杰;赵志刚;;泰脂安治疗老年高脂血症的疗效评价[A];第七届全国老年医学学术会议暨海内外华人老年医学学术会议论文汇编[C];2004年

5 白利颖;王贵芝;李湘萍;杨丽;;72例老年高脂血症患者饮食状况分析[A];全国第11届老年护理学术交流暨专题讲座会议论文汇编[C];2008年

6 于小妹;李铎;谢海宝;张永华;王强;周筱琼;于澎;王丽君;;中老年高脂血症患者血小板磷酯脂肪酸与血栓危害因子相关性研究[A];2006年浙江省检验医学学术年会论文汇编[C];2006年

7 申琳;崔君;;多廿烷醇和瑞舒伐他汀治疗老年高脂血症的成本-效果分析[A];第十三次全国心血管病学术会议论文集[C];2011年

8 粟茂;杨景霞;;中医针药治疗老年高脂血症的临床疗效观察(摘要)[A];第三次全国中西医结合养生学与康复医学学术研讨会论文集[C];2002年

9 崔大江;傅小平;郅敏;;泰脂安对老年高脂血症患者C反应蛋白的影响[A];第七届全国老年医学学术会议暨海内外华人老年医学学术会议论文汇编[C];2004年

相关重要报纸文章 前2条

1 ;如何应对老年高脂血症[N];北京社会报;2008年

2 解放军总医院 司全金 刘秀云 叶平 李小鹰 尚延中 王士雯;小剂量辛伐他丁对老年高脂血症的疗效观察[N];中国高新技术产业导报;2001年

相关硕士学位论文 前5条

1 康诵清;益脉颗粒治疗老年高脂血症气虚血瘀证的临床疗效观察[D];山东中医药大学;2015年

2 黄怡娴;化浊剔络方对老年高脂血症痰瘀互结证临床疗效及炎性因子的研究[D];南京中医药大学;2017年

3 何碧秀;不同剂量辛伐他汀治疗老年高脂血症疗效及安全性观察[D];中南大学;2003年

4 王之琳;固本祛瘀，化痰调脂法治疗老年高脂血症的临床观察[D];山东中医药大学;2012年

5 万琦兵;脉安口服液治疗老年高脂血症临床研究[D];湖北中医学院;2003年

，

本文编号：2174028