化浊剔络方对老年高脂血症痰瘀互结证临床疗效及炎性因子的研究
[Abstract]:Objective to observe the clinical efficacy of Huazhuo Tiluo recipe in treating senile hyperlipidemia with phlegm and blood stasis syndromes in the aspects of TCM symptom score, blood lipid index (TCU TGG LDLX HDL), and inflammatory factor (hs-CRPU IL-6 TNF- 伪), and to evaluate its safety. To provide a new way of diagnosis and treatment for senile hyperlipidemia with traditional Chinese medicine. Methods A total of 60 patients with hyperlipidemia diagnosed by western medicine and TCM diagnostic criteria of phlegm and blood stasis syndromes were included in this study. The patients were divided into observation group and control group according to the method of random control, with 30 patients in each group. The control group was given Atto vastatin calcium tablet, the observation group was treated with Huazhuo Tiluo recipe combined with Atto vastatin calcium tablet, and the traditional Chinese medicine decoction was taken orally. The course of treatment was 4 weeks in both groups. Before and after treatment, the changes of TCM symptom scores and the changes of HDLHs-CRPPIL-6 TNF- 伪 were observed, and the adverse reactions and safety of the patients were evaluated. Finally, all the data are analyzed by SPSS19.0 statistical software. Results there was no significant difference between the two groups in age, sex, TCM symptom score, blood lipid index, inflammatory factors and other baseline (P0.05), the two groups were comparable. TCM symptom score comparison: two groups of patients after treatment of TCM symptom scores were significantly decreased (P0.05), the observation group than the control group has a significant difference (P0.05); symptom efficacy: the observation group total effective rate was 96.3G, the control group total effective rate was 73.3cm, there was significant statistical difference (P0.05). Analysis of the effect of lowering fat and clinical curative effect of western medicine: the patients in the observation group and the control group were significantly improved in HDL after treatment (P0.01), and the comparison was made between the two groups after treatment. Compared with the control group, the improvement of TCU LDL in the observation group was significantly different from that in the control group (P0.05). There was no significant difference in the improvement of TGG HDL (P0.05); the total effective rate of the observation group was 86.7%, the total effective rate of the control group was 80%, and there was no significant difference between the two groups (P0.05). Comparison of inflammatory factors: after treatment, the level of hs-CRPnil IL-6 in two groups was significantly lower than that before treatment (P0.05). There was no significant difference in TNF- 伪 between the two groups (P0.05), and there was no significant difference between the two groups after treatment (P0.05). No adverse reactions were observed throughout the study. Conclusion 1. Huazhuo Tiluo recipe can effectively improve the elderly hyperlipidemia clinical symptoms. 2. Huazhuo Tiluo recipe can improve the level of TCU LDL in senile hyperlipidemia patients with phlegm and blood stasis syndrome. Huazhuo Tiluo recipe can reduce the level of hs-CRPU IL-6 in senile hyperlipidemia patients with phlegm and blood stasis syndrome. 4. Huazhuo Tiluo recipe is safe and effective in the treatment of senile hyperlipidemia.
【学位授予单位】:南京中医药大学
【学位级别】:硕士
【学位授予年份】:2017
【分类号】:R259
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