中药治疗围绝经期功血临床疗效系统评价

发布时间：2018-08-10 19:15

【摘要】：目的:系统分析中药治疗围绝经期功血的有效性、安全性,以期做出客观且可信的评价,为围绝经期功血的临床用药治疗提供有利依据。讨论有关中药治疗围绝经期功血临床研究中存在的问题,提出解决意见。方法:1全面检索2005年1月1日至2016年6月30日国内外各期刊已发表或未发表的有关中药治疗围绝经期功血的临床研究文献;2根据纳入、排除标准筛选出有关中药与西药治疗围绝经期功血的随机对照试验(RCT)或半随机对照(qRCT)的临床研究文献;3对符合纳入标准的文献进行质量评价及风险偏倚评估;4提取文献资料,应用RevMan5.2软件进行Meta分析合并效应量。结果:本次研究共检索出文献475篇,按照纳入标准和排除标准,最终纳入36篇中文文献,涉及参与试验者3563例,应用Jadad量表质量评价,35篇低于3分,1篇4分。经分析结果显示:中药治疗围绝经期功血在临床有效率、中医症候疗效、中医症候积分、血常规、激素水平、不良反应发生率、复发率等方面相比西药治疗有优势,但两者的止血时间疗效和子宫内膜厚度治疗结果无明显差异。结论:中药治疗围绝经期功血与西药治疗围绝经期功血的疗效有显著差异,中药治疗疗效优于西药治疗。但本次纳入的文献多数质量偏低,研究内容存在很大偏倚,所以当前研究结果尚不能完全适用于临床。
[Abstract]:Objective: to analyze the efficacy and safety of traditional Chinese medicine in the treatment of peri-menopausal dysfunctional blood in order to make an objective and reliable evaluation and to provide a favorable basis for the clinical treatment of peri-menopausal dysfunctional blood. This paper discusses the problems existing in the clinical study on the treatment of peri-menopausal dysfunctional blood with Chinese medicine, and puts forward some suggestions. Methods from January 1, 2005 to June 30, 2016, the literature on clinical research on the treatment of peri-menopausal dysfunctional blood by traditional Chinese medicine was searched according to the inclusion of the literature published or not published in various domestic and foreign journals from January 1, 2005 to June 30, 2016. A randomized controlled trial (RCT) or a semi-randomized controlled (qRCT) (qRCT) clinical study on the treatment of menopausal dysfunctional blood with traditional Chinese medicine and western medicine was selected. The quality evaluation and risk bias assessment of the literature in accordance with the inclusion criteria were used to extract the literature data. The combined effect was analyzed by Meta with RevMan5.2 software. Results: a total of 475 articles were retrieved in this study. According to the inclusion criteria and exclusion criteria, 36 Chinese articles were included, involving 3563 participants. The quality evaluation of 35 articles with Jadad scale was less than 3 points and 1 article was 4 points. The results of analysis showed that the clinical effective rate, the curative effect of TCM symptom, the score of TCM symptom, the blood routine, the hormone level, the incidence rate of adverse reaction, the recurrence rate and so on of traditional Chinese medicine were superior to those of western medicine in the treatment of peri-menopausal dysfunctional blood. However, there was no significant difference in hemostatic time and endometrial thickness between the two groups. Conclusion: there is significant difference between Chinese medicine and western medicine in the treatment of peri-menopausal dysfunctional blood, and the curative effect of traditional Chinese medicine is better than that of western medicine. However, most of the literature included in this paper is of low quality and the research content is biased, so the current research results are not fully applicable to clinical practice.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

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