加味苦参汤治疗手部湿疹急性期的临床疗效观察
发布时间：2018-08-15 11:30
【摘要】：目的研究加味苦参汤治疗手部湿疹急性期的临床疗效,观察加味苦参汤对于缓解手部湿疹急性期的皮损、瘙痒等方面的作用,探讨其治疗手部湿疹急性期的机理,为临床治疗湿疹开拓新思路、新方法。方法对手部湿疹急性期患者进行随机分组,以加味苦参汤湿敷作为中药治疗组,并设立氢化可的松溶液湿敷作为西药对照组,其中中药治疗组30例,西药对照组30例。在研究过程中保存病人的相关资料(治疗前、后的皮损评分、瘙痒程度评分、照片)治疗1周为1疗程,分别在治疗1个疗程和2个疗程后观察两组患者治疗前后相关指标,并进行统计学处理。结果(1)一般资料比较：经分析中药治疗组与西药对照组样本在年龄、性别以及病程方面不具有统计学意义(P0.05),具有可比性。(2)皮疹积分比较：两组患者治疗一周和两周后皮损皆有好转,其中中药治疗组治疗一周后和治疗两周后疗效皆优于西药对照组(P0.05),且有统计学意义。(3)瘙痒程度改善比较：两组患者在经过一周治疗后瘙痒均有减轻,但其程度无明显差异(P0.05),无统计学意义；治疗两周后,瘙痒有不同程度的减轻,且中药治疗组优于西药对照组(P0.05),差异有统计学意义。(4)两组患者经过2个疗程的相应治疗,中药治疗组总有效率为96.7%,其中基本治愈4例,显效25例,有效0例,无效1例；西药对照组总有效率为80.0%,其中基本治愈1例,显效14例,有效9例,无效6例,中药治疗组治疗效果明显优于西药对照组(P0.005),具有统计学意义。结论在手部湿疹急性期患者的临床治疗中使用加味苦参汤湿敷,能够明显改善患者的临床症状,虽然其起效时间较激素湿敷长,但远期治疗效果优于激素湿敷,可以作为手部湿疹急性期患者临床治疗的一种新的选择方案,在临床中推广应用。
[Abstract]:Objective to study the clinical effect of Jiawei Sophora decoction on acute hand eczema, observe the effect of Jiawei Sophora decoction on relieving skin damage and pruritus in acute stage of hand eczema, and explore its mechanism of treating hand eczema in acute stage. To develop new ideas and methods for clinical treatment of eczema. Methods the patients with hand eczema in acute stage were randomly divided into two groups: the treated group was treated with modified Kushen decoction and the control group was treated with hydrocortisone solution wet compress. 30 cases were treated with traditional Chinese medicine and 30 cases were treated with western medicine. During the course of the study, the relevant data of the patients (before and after the treatment, the score of pruritus, the photo) were kept for one course of treatment. The related indexes before and after treatment were observed in the two groups, respectively, after one course of treatment and two courses of treatment. Statistical analysis was carried out. Results (1) comparison of general data: the samples of the Chinese medicine treatment group and the western medicine control group were analyzed at the age, Sex and course of disease were not statistically significant (P0.05), comparable. (2) rash score comparison: two groups of patients after one week and two weeks of treatment of skin lesions improved, After one week treatment and two weeks treatment, the curative effect of the Chinese medicine treatment group was better than that of the western medicine control group (P0.05), and there was statistical significance. (3) the degree of pruritus was improved by comparison: after one week treatment, the pruritus of the two groups were all alleviated. But there was no significant difference (P0.05), there was no statistical significance; after two weeks of treatment, itching was alleviated to some extent, and the Chinese medicine treatment group was superior to the western medicine control group (P0.05). (4) the two groups of patients after two courses of corresponding treatment, the Chinese medicine treatment group is better than the western medicine control group (P0.05). (4) the two groups of patients after two courses of corresponding treatment, The total effective rate of the Chinese medicine treatment group was 96.7%, of which 4 cases were basically cured, 25 cases were markedly effective, 0 cases were effective, and 1 case was ineffective, while the total effective rate in the western medicine control group was 80.0%, in which 1 case was basically cured, 14 cases were markedly effective, 9 cases were effective, and 6 cases were ineffective. The therapeutic effect of traditional Chinese medicine group was significantly better than that of western medicine control group (P 0.005), with statistical significance. Conclusion the application of modified Kushen decoction in the treatment of hand eczema in acute stage can obviously improve the clinical symptoms of the patients. Although the effective time is longer than that of hormone wet compress, the long-term therapeutic effect is better than that of hormone wet compress. It can be used as a new choice for the treatment of hand eczema in acute stage.
【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9
[Abstract]:Objective to study the clinical effect of Jiawei Sophora decoction on acute hand eczema, observe the effect of Jiawei Sophora decoction on relieving skin damage and pruritus in acute stage of hand eczema, and explore its mechanism of treating hand eczema in acute stage. To develop new ideas and methods for clinical treatment of eczema. Methods the patients with hand eczema in acute stage were randomly divided into two groups: the treated group was treated with modified Kushen decoction and the control group was treated with hydrocortisone solution wet compress. 30 cases were treated with traditional Chinese medicine and 30 cases were treated with western medicine. During the course of the study, the relevant data of the patients (before and after the treatment, the score of pruritus, the photo) were kept for one course of treatment. The related indexes before and after treatment were observed in the two groups, respectively, after one course of treatment and two courses of treatment. Statistical analysis was carried out. Results (1) comparison of general data: the samples of the Chinese medicine treatment group and the western medicine control group were analyzed at the age, Sex and course of disease were not statistically significant (P0.05), comparable. (2) rash score comparison: two groups of patients after one week and two weeks of treatment of skin lesions improved, After one week treatment and two weeks treatment, the curative effect of the Chinese medicine treatment group was better than that of the western medicine control group (P0.05), and there was statistical significance. (3) the degree of pruritus was improved by comparison: after one week treatment, the pruritus of the two groups were all alleviated. But there was no significant difference (P0.05), there was no statistical significance; after two weeks of treatment, itching was alleviated to some extent, and the Chinese medicine treatment group was superior to the western medicine control group (P0.05). (4) the two groups of patients after two courses of corresponding treatment, the Chinese medicine treatment group is better than the western medicine control group (P0.05). (4) the two groups of patients after two courses of corresponding treatment, The total effective rate of the Chinese medicine treatment group was 96.7%, of which 4 cases were basically cured, 25 cases were markedly effective, 0 cases were effective, and 1 case was ineffective, while the total effective rate in the western medicine control group was 80.0%, in which 1 case was basically cured, 14 cases were markedly effective, 9 cases were effective, and 6 cases were ineffective. The therapeutic effect of traditional Chinese medicine group was significantly better than that of western medicine control group (P 0.005), with statistical significance. Conclusion the application of modified Kushen decoction in the treatment of hand eczema in acute stage can obviously improve the clinical symptoms of the patients. Although the effective time is longer than that of hormone wet compress, the long-term therapeutic effect is better than that of hormone wet compress. It can be used as a new choice for the treatment of hand eczema in acute stage.
【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9
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