泻浊宣痹汤治疗肺痹邪盛痹重期（肠胃湿热，肺络痹阻）的临床疗效观察
发布时间：2018-08-17 17:26
【摘要】：目的:本课题主要通过中西医诊断标准选取的60例病例,进行对比、观察临床疗效,合理阐述肠胃湿热,肺络痹阻对肺痹的影响及其病因病机,进一步评价泻浊宣痹汤治疗肺痹邪盛痹重期(肠胃湿热,肺络痹阻)的有效性、及时性及安全性,观察其治疗本病标证的可行性;完善导师王檀教授对于肠胃湿热对间质性肺疾病影响的理论内涵。方法:病例皆来源于2014年12月至2016年2月长春中医药大学附属医院肺病科门诊及住院患者,对符合诊断标准、纳入标准,经剔除标准筛选的入选病例作为受试对象,共计纳入60例,将患者随机分为对照组(乙酰半胱氨酸泡腾片+罗红霉素片)和观察组(在对照组基础上,服用泻浊宣痹汤),每组30例。两组一般资料及治疗前主次症、理化检查:肺功能(VC、DLco值);血氧饱和度;六分钟步行试验,经统计学检验有无差异。经过1周的临床观察,对比治疗前后的主次症及理化检查,评价泻浊宣痹汤治疗肺痹邪盛痹重期(肠胃湿热,肺络痹阻)的疗效。结果:经临床观察及统计学分析得出,泻浊宣痹汤对肺痹·邪盛痹重期(肠胃湿热,肺络痹阻)的治疗,其总疗效显效率,有效率,均优于对照组,且具有显著差异(P0.05)。通过此临床观察可知,泻浊宣痹汤对肺痹·邪盛痹重期(肠胃湿热,肺络痹阻)的主症及次症改善均比较明显,尤其在改善次要症状:口中异味,脘腹胀满,排便困难、便质粘腻等方面尤其突出。对比观察组及对照组治疗前后的肺功能(VC、DLco)、血氧饱和度、六分钟步行试验,在治疗前后均有差异,治疗后优于治疗前。然而两组之间比较后无明显差异,即提示泻浊宣痹汤在理化检查方面无额外优势,中医治疗重在调整当前肠胃湿热状态,改善临床症状。结论:泻浊宣痹汤可明显改善肺痹邪盛痹重期(肠胃湿热,肺络痹阻)患者的临床症状,快速去除加重肺痹进展或复发的影响因素,使肺痹的本质-肺气不足,肺中虚冷充分暴露,进而及早进入对其本质治疗。其临床疗效确切,安全可靠,发挥了中医药辨证施治的优势,缩短了治疗疗程,最大程度地减轻了患者痛苦。
[Abstract]:Objective: to compare 60 cases selected by traditional Chinese and western medicine diagnostic criteria, observe the clinical curative effect, expound the influence of dampness and heat of stomach and the obstruction of lung collaterals on lung arthralgia and its etiology and pathogenesis. To further evaluate the efficacy, timeliness and safety of Xiezhuxuanbi decoction in treating the severe stage of lung arthralgia, including dampness and heat of the stomach and collaterals of the lung, and to observe the feasibility of the treatment of the standard syndrome of this disease. Improve the theoretical implications of tutors Professor Wang Tan on interstitial lung disease caused by intestinal dampness and heat. Methods: all the cases were collected from December 2014 to February 2016 in the Department of Pulmonary Diseases of Changchun University of traditional Chinese Medicine. The patients who met the diagnostic criteria were included in the criteria, and the selected cases selected by the exclusion criteria were selected as the subjects. A total of 60 patients were randomly divided into control group (acetylcysteine effervescent tablets roxithromycin tablets) and observation group (on the basis of control group, taking Xiezhuxuanbi decoction), 30 cases in each group. Physical and chemical examination: pulmonary function (VCU DLCO value); blood oxygen saturation; 6-minute walking test. After 1 week's clinical observation, comparing the primary and secondary symptoms and physical and chemical examination before and after treatment, the curative effect of Xiezhuoxuanbi decoction (XZXB) on the severe stage of lung arthralgia with dampness and heat of the stomach and obstruction of the collaterals of the lung was evaluated. Results: the clinical observation and statistical analysis showed that Xiezhuxuanbi decoction was better than the control group in the treatment of the severe stage of lung arthralgia (enterogastric dampness and heat, obstruction of the lung collaterals and arthralgia), and there was significant difference (P0.05). According to this clinical observation, Xiezhuxuanbi decoction can obviously improve the main symptoms and secondary symptoms of lung arthralgia, especially in improving secondary symptoms, such as peculiar smell in mouth, full abdominal distention, difficulty in defecation, and difficulty in defecation, especially in the improvement of secondary symptoms: peculiar smell in mouth, full abdominal distention, and difficulty in defecation. The fecal quality is sticky and greasy, etc. The pulmonary function (VCU DLco), blood oxygen saturation and six minute walking test before and after treatment in the observation group and the control group were all different before and after treatment, and were better than before and after treatment. However, there is no significant difference between the two groups after comparison, that is, Xiesezhuo Xuanbi decoction has no additional advantages in physical and chemical examination, and TCM treatment focuses on adjusting the current state of intestinal dampness and heat and improving clinical symptoms. Conclusion: Xiezhuxuanbi decoction can obviously improve the clinical symptoms of the patients in the severe stage of lung arthralgia, such as dampness and heat of the stomach, obstruction of the collaterals of the lung, quickly remove the influencing factors that aggravate the progress or relapse of the lung arthralgia, and make the essence of the lung arthralgia-the deficiency of lung qi. Deficiency cold in the lung is fully exposed, and then enter into the treatment of its essence as soon as possible. Its clinical curative effect is exact, safe and reliable, it exerts the advantage of TCM syndrome differentiation and treatment, shortens the course of treatment, and relieves the patient's pain to the greatest extent.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2188363
[Abstract]:Objective: to compare 60 cases selected by traditional Chinese and western medicine diagnostic criteria, observe the clinical curative effect, expound the influence of dampness and heat of stomach and the obstruction of lung collaterals on lung arthralgia and its etiology and pathogenesis. To further evaluate the efficacy, timeliness and safety of Xiezhuxuanbi decoction in treating the severe stage of lung arthralgia, including dampness and heat of the stomach and collaterals of the lung, and to observe the feasibility of the treatment of the standard syndrome of this disease. Improve the theoretical implications of tutors Professor Wang Tan on interstitial lung disease caused by intestinal dampness and heat. Methods: all the cases were collected from December 2014 to February 2016 in the Department of Pulmonary Diseases of Changchun University of traditional Chinese Medicine. The patients who met the diagnostic criteria were included in the criteria, and the selected cases selected by the exclusion criteria were selected as the subjects. A total of 60 patients were randomly divided into control group (acetylcysteine effervescent tablets roxithromycin tablets) and observation group (on the basis of control group, taking Xiezhuxuanbi decoction), 30 cases in each group. Physical and chemical examination: pulmonary function (VCU DLCO value); blood oxygen saturation; 6-minute walking test. After 1 week's clinical observation, comparing the primary and secondary symptoms and physical and chemical examination before and after treatment, the curative effect of Xiezhuoxuanbi decoction (XZXB) on the severe stage of lung arthralgia with dampness and heat of the stomach and obstruction of the collaterals of the lung was evaluated. Results: the clinical observation and statistical analysis showed that Xiezhuxuanbi decoction was better than the control group in the treatment of the severe stage of lung arthralgia (enterogastric dampness and heat, obstruction of the lung collaterals and arthralgia), and there was significant difference (P0.05). According to this clinical observation, Xiezhuxuanbi decoction can obviously improve the main symptoms and secondary symptoms of lung arthralgia, especially in improving secondary symptoms, such as peculiar smell in mouth, full abdominal distention, difficulty in defecation, and difficulty in defecation, especially in the improvement of secondary symptoms: peculiar smell in mouth, full abdominal distention, and difficulty in defecation. The fecal quality is sticky and greasy, etc. The pulmonary function (VCU DLco), blood oxygen saturation and six minute walking test before and after treatment in the observation group and the control group were all different before and after treatment, and were better than before and after treatment. However, there is no significant difference between the two groups after comparison, that is, Xiesezhuo Xuanbi decoction has no additional advantages in physical and chemical examination, and TCM treatment focuses on adjusting the current state of intestinal dampness and heat and improving clinical symptoms. Conclusion: Xiezhuxuanbi decoction can obviously improve the clinical symptoms of the patients in the severe stage of lung arthralgia, such as dampness and heat of the stomach, obstruction of the collaterals of the lung, quickly remove the influencing factors that aggravate the progress or relapse of the lung arthralgia, and make the essence of the lung arthralgia-the deficiency of lung qi. Deficiency cold in the lung is fully exposed, and then enter into the treatment of its essence as soon as possible. Its clinical curative effect is exact, safe and reliable, it exerts the advantage of TCM syndrome differentiation and treatment, shortens the course of treatment, and relieves the patient's pain to the greatest extent.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
【参考文献】
相关期刊论文 前10条
1 沈爱娟;蔡宛如;;蔡宛如运用益气养阴化瘀法治疗间质性肺病经验[J];浙江中医杂志;2014年09期
2 刘晓明;张伟;;从毒、虚论述肺间质纤维化的病因病机[J];南京中医药大学学报;2014年04期
3 熊艳云;李俐;叶焰;刘红宇;;中药保留灌肠联合常规西医治疗发作期热哮疗效观察[J];山西中医学院学报;2014年03期
4 袁成波;王檀;仕丽;;暖肝除痹汤治疗间质性肺疾病肝肾阴寒证[J];吉林中医药;2013年12期
5 谭晓丽;王真;;从瘀论治间质性肺疾病[J];长春中医药大学学报;2013年06期
6 吴晶金;刘维;;从肺痹辨治结缔组织病相关肺间质病变[J];山东中医杂志;2013年02期
7 李建生;宋建平;;正虚络痹积损为弥漫性间质性肺疾病的主要病机[J];中医杂志;2013年01期
8 邢筱华;;保元胶囊对特发性肺纤维化患者肺功能的影响[J];陕西中医;2012年12期
9 孙英坤;赵琦;邵玉霞;;N-乙酰半胱氨酸治疗特发性肺纤维化的临床分析[J];哈尔滨医科大学学报;2012年05期
10 仕丽;王檀;胡少丹;张丽秀;田琳;;温肺化纤方外敷治疗间质性肺疾病60例临床观察[J];中医临床研究;2012年16期
相关会议论文 前1条
1 陶凯;;间质性肺疾病的中西医结合治疗[A];《全国中医药防治老年病及老年呼吸疾病学术讲坛》学术论文集[C];2007年
相关硕士学位论文 前6条
1 谢昭;周平安教授治疗特发性肺纤维化经验总结[D];北京中医药大学;2015年
2 肖星媛;滋补肺肾汤治疗间质性肺疾病（肺肾阴虚，肺络不畅证）的临床观察[D];长春中医药大学;2013年
3 康长生;中医“肺病及肠”理论及其传变规律和特点的研究[D];福建中医药大学;2012年
4 谢淑华;肺痹、肺痿与肺间质纤维化的相关性研究[D];北京中医药大学;2009年
5 袁成波;小青龙汤加味治疗间质性肺疾病（ILD）—（寒饮伏肺，，肺络痹阻证）的临床研究[D];长春中医药大学;2009年
6 肖振平;IPF的HRCT表现与肺功能及支气管肺泡灌洗液细胞学相关性研究[D];中国医科大学;2006年
本文编号：2188363
本文链接：https://www.wllwen.com/zhongyixuelunwen/2188363.html
最近更新
教材专著
