代综方改善38例代谢综合征糖脂代谢异常的临床研究

发布时间：2018-08-20 10:46

【摘要】：目的:观察代综方颗粒治疗代谢综合征(metabolic syndrome,MS)糖脂代谢紊乱的临床安全性和有效性。方法:采用自身前后对照的方法,给予MS患者代综方配方颗粒剂治疗8周。治疗前后分别观察血尿常规、肝肾功能、心电图、肝脏超声及腰围、体重指数、血糖、血脂、血压、空腹胰岛素、空腹c肽和中医临床症状。填写病例观察表,录入epidata数据库,复核数据剔除不合格病例,SPSS 17.0统计分析。结果:(1)完成45例,脱落1例、不合格6例,共38例纳入统计分析;(2)体重、腰围、体质指数(BMI)较疗前降低(P0.001);(3)改善血糖异常,空腹血糖(FBG)、餐后2 h血糖(PBG-2h)、糖化血红蛋白(Hb A1c)较治疗前降低(P0.001);(4)改善MS患者胰岛素抵抗水平,增加胰岛素敏感性指数(ISI)(P0.05);(5)改善血脂异常,甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)较疗前降低,高密度脂蛋白(HDL-C)升高;(6)治疗后高血压患者血压降低(P0.001);(7)治疗后临床症状、体征改善明显,证候积分改善有效率为97.37%;(8)治疗前后比较,安全性指标未见异常。结论:代综方颗粒能够降低代谢综合征高血糖、高血脂患者的血糖血脂水平,改善代谢紊乱,安全有效。
[Abstract]:Objective: to observe the clinical safety and efficacy of Daizhuangfang granule in the treatment of glucose and lipid metabolic disorder in metabolic syndrome (MS). Methods: the patients with MS were treated with comprehensive prescription granules for 8 weeks. Blood routine, liver and kidney function, electrocardiogram, liver ultrasound and waist circumference, body mass index, blood glucose, blood lipid, blood pressure, fasting insulin, fasting c-peptide and clinical symptoms of TCM were observed before and after treatment. Fill out the case observation form, input into the epidata database, and check the data to eliminate the unqualified cases and the statistical analysis of SPSS 17.0. Results: (1) 45 cases were completed, 1 case was lost, 6 cases were not qualified, 38 cases were included in statistical analysis, (2) body weight, waist circumference and body mass index (BMI) decreased compared with those before treatment (P0. 001); (3). Fasting blood glucose (FBG),) 2 h postprandial blood glucose (PBG-2h), glycosylated hemoglobin (HbA1c) decreased compared with pre-treatment (P0.001); (4) to improve insulin resistance in MS patients, and increased insulin sensitivity index (ISI) (P0.05); (5) to improve dyslipidemia. Triglyceride (TG), cholesterol (TC), low density lipoprotein (LDL-C) was lower and high density lipoprotein (HDL-C) was higher than that before treatment. (6) after treatment, the clinical symptoms and signs of hypertension patients decreased significantly after treatment (P0.001); (7). The effective rate of syndromes integral improvement was 97.37. (8) there was no abnormal safety index before and after treatment. Conclusion: Daizhuofang granule can reduce hyperglycemia and hyperlipidemia in patients with metabolic syndrome, improve metabolic disorder, and be safe and effective.
【作者单位】：中国中医科学院广安门医院;保定市第一中医院;南京市中医院;北京市密云县河南寨社区;
【基金】：国际科技合作项目(2010DFA31620) 科技部重大新药创制项目(2011ZX09102-011-08)
【分类号】：R259

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