清热化瘀方治疗急性缺血性中风的临床疗效观察及其作用机制研究

发布时间：2018-08-20 14:17

【摘要】：目的:观察清热化瘀方对急性缺血性中风患者的临床疗效,并从脑特异性蛋白S-100b与神经原特异性烯醇化酶(NSE)角度探讨其可能的作用机制。方法:将192例急性缺血性中风病风火痰瘀痹阻证患者随机分为治疗组98例(基础治疗+清热化瘀方)和对照组94例(基础治疗+吡拉西坦片),每组用药疗程均为4周。运用改良Rankin量表和BI指数分别评估患者治疗前后神经功能恢复结局与日常生活能力的变化,并用酶联免疫吸附法(ELISA)检测治疗前后患者血清S-100b与NSE蛋白的变化。结果:(1)两组治疗后改良Rankin量表评分与BI指数均较治疗前有显著改善(P0.05),且治疗组改善程度优于对照组(P0.05)。(2)两组治疗后血清S-100b、NSE水平均明显降低(P0.05),且治疗组较对照组降低更为明显(P0.05)。结论:清热化瘀方能明显改善急性缺血性中风病风火痰瘀痹阻证患者的卒中后功能恢复结局和日常生活能力,其机制可能与降低患者血清S-100b、NSE水平有关。
[Abstract]:Objective: to observe the clinical effect of Qingre Huayu recipe on acute ischemic apoplexy and to explore its possible mechanism from the point of view of brain specific protein S-100b and neurogen-specific enolase (NSE). Methods: 192 patients with acute ischemic stroke were randomly divided into treatment group (98 cases) and control group (94 cases) treated with Piracetam for 4 weeks. Modified Rankin scale and BI index were used to evaluate the changes of neurological function recovery outcome and ADL before and after treatment, and the changes of serum S-100b and NSE protein before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA). Results: (1) after treatment, the scores of modified Rankin scale and BI index were significantly improved in both groups (P0.05), and the improvement degree of the treatment group was better than that of the control group (P0.05). (2). After treatment, the serum S-100bNSE level in the treatment group was significantly lower than that in the control group (P0.05), and the decrease in the treatment group was more obvious than that in the control group (P0.05). Conclusion: Qingre Huayu prescription can obviously improve the functional recovery outcome and daily living ability of patients with acute ischemic apoplexy syndrome of wind-fire phlegm-stasis obstruction syndrome, and its mechanism may be related to the decrease of serum S-100bNSE level.
【作者单位】：广西中医药大学第一附属医院;南宁市中医院;南宁市宾阳县中医院;丽水市中医院;
【基金】：国家自然科学基金(81560759) 广西中医药管理局中医药民族医药传承创新专项课题(GZLC14-01)
【分类号】：R255.2

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