滋阴潜阳辨证治疗顽固性高血压合并颈动脉粥样硬化相关指标及疗效观察

发布时间：2018-08-21 13:56

【摘要】：目的:探讨滋阴潜阳辨证治疗顽固性高血压合并颈动脉粥样硬化患者NO、CGRP以及生存质量的影响。方法:选取医院2013年8月—2016年1月收治的顽固性高血压合并颈动脉粥样硬化患者84例,按随机数字表法分组,分别42例,对照组予以降压、稳定斑块治疗;研究组在降压、稳定斑块基础上予以滋阴潜阳辨证治疗,共治疗2个月为1疗程,采血测定炎症因子以及血管内皮功能,超声观察颈动脉粥样硬化斑块改变,记录SF-36生存质量,同时对比临床疗效。结果:与治疗前比较,两组治疗后FMD升高,斑块Crouse积分、IMT降低,治疗后生理功能、总体健康、活力、社会功能、精神健康评分升高,治疗后IL-6、CRP、vWF含量降低,治疗后ET降低,NO、CGRP含量升高(P0.05);与对照组比较,研究组治疗后FMD较高,斑块Crouse积分、IMT较低,治疗后生理功能、总体健康、活力、社会功能、精神健康评分较高,治疗后IL-6、CRP、vWF含量较低,治疗后ET较低,NO、CGRP含量较高(P0.05);对照组有效率71.43%与研究组有效率90.48%数据对比,研究组高于对照组(P0.05)。结论:滋阴潜阳辨证治疗顽固性高血压合并颈动脉粥样硬化疗效确切,稳定斑块,改善内皮功能及炎症指标,提高生存质量。
[Abstract]:Objective: to explore the effect of differentiation of nourishing yin and burying yang on NO-CGRP and quality of life in patients with intractable hypertension complicated with carotid atherosclerosis. Methods: from August 2013 to January 2016, 84 patients with intractable hypertension complicated with carotid atherosclerosis were selected and divided into two groups: 42 patients in the control group were treated with hypotension and plaque stabilization. The stable plaque was treated with syndrome differentiation of nourishing yin and burying yang for 2 months. The inflammatory factors and vascular endothelial function were measured by blood collection, the changes of carotid atherosclerotic plaque were observed by ultrasound, and the quality of life of SF-36 was recorded. At the same time, the clinical efficacy was compared. Results: compared with before treatment, FMD increased, plaque Crouse score decreased, physiological function, general health, vitality, social function and mental health scores increased after treatment, and the content of IL-6 / CRP VWF decreased after treatment. Compared with the control group, the content of FMD was higher, the Crouse score of plaque was lower, the physiological function, general health, vitality, social function, mental health score were higher in the study group than in the control group (P0.05), and the content of IL-6 CRPvWF was lower in the study group than in the control group. After treatment, the content of CGRP in et was higher than that in control group (P0.05), the effective rate of control group was 71.43% and the effective rate of study group was 90.48%, which was higher than that of control group (P0.05). Conclusion: it is effective to treat refractory hypertension with carotid atherosclerosis by syndrome differentiation of nourishing yin and burying yang, to stabilize plaque, to improve endothelial function and inflammation index, and to improve quality of life.
【作者单位】：河北医科大学第二医院心内科;
【基金】：石家庄市科技局科技支撑计划项目[石科(2013)69]
【分类号】：R259

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