小柴胡汤加减治疗慢传输型便秘（肠道气滞型）的临床疗效评价

发布时间：2018-08-25 07:28

【摘要】：目的:对小柴胡汤加减治疗慢传输型便秘(肠道气滞型)进行临床疗效分析,并探讨其机理。资料与方法:研究资料均选自于2015年1月至2016年6月就诊于辽宁中医药大学附属第三医院(辽宁省肛肠医院)确诊为慢传输型便秘(肠道气滞型),并符合纳入标准的门诊患者,共64例。按随机数字表法将所选患者随机分为治疗组(小柴胡汤加减组)33例,对照组(木香槟榔丸组)31例。治疗组予以小柴胡汤加减治疗,水煎服,日3次,100ml/次;对照组予以木香槟榔丸治疗,口服,日3次,1袋/次。两组均以2周为1疗程,治疗2个疗程后对研究结果进行统计。观察两组治疗前后焦虑、抑郁评分,结肠传输试验72小时标记物排出粒数,便秘症状总积分及临床疗效、安全性等。用SPSS17.0统计软件对临床数据进行统计分析并对结果加以分析评价。结果:1.在焦虑、抑郁评分方面,两组均较治疗前有明显降低(P0.05),且治疗组降低幅度明显优于对照组(P0.05)。2.在结肠传输试验72小时标记物排出粒数方面,两组均较治疗前有明显增加(P0.05),且治疗组增加幅度明显优于对照组(P0.05)。3.在便秘症状总积分方面,两组均较治疗前有明显降低(P0.05),且治疗组降低幅度明显优于对照组(P0.05)。4.治疗组总有效率83.33%,对照组总有效率73.33%,两组总体疗效存在差异(P0.05)。5.两组治疗期间均未出现明显不良反应及毒副作用,说明两组药物安全性好。结论:小柴胡汤加减治疗慢传输型便秘(肠道气滞型)在改善患者焦虑、抑郁症状,增加结肠传输试验72小时标记物排出粒数,降低便秘症状总积分及临床疗效等方面均优于对照组,安全有效,值得临床应用与推广。
[Abstract]:Objective: to analyze the therapeutic effect of Xiaocaihu decoction on slow transit constipation (intestinal qi stagnation type) and explore its mechanism. Materials and methods: all the data were selected from January 2015 to June 2016 in the third affiliated Hospital of Liaoning University of traditional Chinese Medicine (Liaoning anorectal Hospital), which were diagnosed as slow transit constipation (intestinal qi stagnation type). There were 64 cases. The patients were randomly divided into treatment group (Xiaochaihu decoction subtraction group) and control group (Muxiang areca pill group). The treatment group was treated with Xiaochaihu decoction, water decoction, 3 times a day, 100 ml / time; the control group was treated with Muxiang betel nut pills, orally, 3 times a day, 1 bag per time. The two groups were treated with 2 weeks as a course of treatment, and the results were statistically analyzed after 2 courses of treatment. The scores of anxiety and depression before and after treatment, the number of markers excreted in 72 hours, the total score of constipation symptoms, the clinical efficacy and the safety of the two groups were observed. The clinical data were statistically analyzed by SPSS17.0 software and the results were analyzed and evaluated. The result is 1: 1. In terms of anxiety and depression scores, the two groups were significantly lower than before treatment (P0.05), and the treatment group significantly better than the control group (P0.05). 2. In colon transmission test 72 hours after treatment, the number of markers excreted from both groups were significantly increased (P0.05), and the treatment group was significantly better than the control group (P0.05). 3. In the total score of constipation symptoms, both groups were significantly lower than before treatment (P0.05), and the treatment group significantly better than the control group (P0.05). 4. The total effective rate of the treatment group was 83.33 and the total effective rate of the control group was 73.33. There was a difference between the two groups (P0.05). There were no obvious adverse reactions and side effects in both groups, indicating that the two groups were safe. Conclusion: Xiaochaihu decoction can improve anxiety and depression in patients with slow transit constipation (intestinal qi stagnation) and increase the number of markers excreted in 72 hours of colon transit test. Reducing the total score of constipation symptoms and clinical efficacy are better than the control group, safe and effective, worthy of clinical application and promotion.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R256.35

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