补肾健脾法治疗老年性痴呆(脾肾两虚型)的临床观察
[Abstract]:Objective: to evaluate the clinical effect of tonifying kidney and invigorating spleen on senile dementia of deficiency of spleen and kidney by comparing the scores of MMSE,ADL scale and syndromes of traditional Chinese medicine (TCM) after treatment with Anlisen alone and the method of tonifying kidney and invigorating spleen. Methods: according to the diagnostic criteria, 48 cases of senile dementia with deficiency of spleen and kidney were selected. The treatment group was randomly divided into three groups: Codonopsis 20g, Astragalus 30g, Atractylodes macrocephala 20g, Herba Epimedii 15g, Radix Rehmanniae 20g, Cistanche Cistanche 30g, Poria cocos 20g, Chenpi 12g, Glycyrrhiza 6g. Two times a day, a bag of 200 ml was taken orally; Donepezil hydrochloride was given 5 mg / d at night before bedtime; in control group, Donepezil hydrochloride was given 5 mg / d before bedtime. 24 cases in each group were treated continuously for 8 weeks. The changes of MMSE,ADL scale and TCM syndrome integral before and after treatment were observed and statistically analyzed. Results: a total of 48 complete cases were collected in both groups. After treatment, the MMSE scores in the two groups were significantly higher than before (P0. 01), and there was significant difference between the two groups (P0.05). The total effective rate of cognitive function improvement was 83.3% in the treatment group and 66.7% in the control group. There was significant difference between the two groups (P0.05). After treatment, the ADL scores of the two groups were significantly lower than before (P0. 01), and there was significant difference between the two groups (P0.05). The total effective rate of the treatment group was 87.5%, while that of the control group was 75%. There was significant difference between the two groups (P0.05). After treatment, the scores of TCM syndromes in the two groups were significantly decreased (P0.01), and there was significant difference between the two groups (P0.05). The total effective rate of the treatment group was 87.5%, while that of the control group was 70.8%. There was significant difference between the two groups (P0.05). Adverse reactions and side effects: there were no abnormal changes in blood, urine, fecal routine, heart, liver and kidney function in the two groups after treatment, and there were no obvious adverse reactions in the treatment group and the control group during the period of clinical observation. Conclusion: the clinical observation shows that the clinical symptoms (cognitive function) of senile dementia treated with tonifying kidney and strengthening spleen combined with Donepezil Hydrochloride are related to the deficiency of spleen and kidney. The improvement of behavioral function and the improvement of TCM syndromes were significantly better than those of the patients with Donepezil hydrochloride alone, and no significant adverse reactions occurred during the clinical observation. Results the method of reaction tonifying the kidney and strengthening the spleen could obviously improve the clinical symptoms, cognitive function and quality of life of the patients with senile dementia with deficiency of spleen and kidney.
【学位授予单位】:河南中医药大学
【学位级别】:硕士
【学位授予年份】:2016
【分类号】:R277.7
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